초록 ▼

A method is provided for preparing a novel therapeutic agent-containing reservoir (26, 28) for use in conjunction with an electrotransport drug delivery system (10). A polymeric matrix is foamed in a selected atmosphere and then cross-linked to form a polymeric closed-cell foam matrix reservoir (26,

A method is provided for preparing a novel therapeutic agent-containing reservoir (26, 28) for use in conjunction with an electrotransport drug delivery system (10). A polymeric matrix is foamed in a selected atmosphere and then cross-linked to form a polymeric closed-cell foam matrix reservoir (26, 28). The method enables relatively smaller quantities of therapeutic agent to be loaded into the electrotransport system (10) and is especially useful for the transdermal delivery of more costly drugs, such as peptides and proteins produced from genetically engineered cell lines, and/or highly potent drugs for which a small dosage is efficacious. Reservoirs (26, 28) prepared according to this method and electrotransport devices (10) containing such reservoirs are also provided.

대표청구항 ▼

A method is provided for preparing a novel therapeutic agent-containing reservoir (26, 28) for use in conjunction with an electrotransport drug delivery system (10). A polymeric matrix is foamed in a selected atmosphere and then cross-linked to form a polymeric closed-cell foam matrix reservoir (26,

A method is provided for preparing a novel therapeutic agent-containing reservoir (26, 28) for use in conjunction with an electrotransport drug delivery system (10). A polymeric matrix is foamed in a selected atmosphere and then cross-linked to form a polymeric closed-cell foam matrix reservoir (26, 28). The method enables relatively smaller quantities of therapeutic agent to be loaded into the electrotransport system (10) and is especially useful for the transdermal delivery of more costly drugs, such as peptides and proteins produced from genetically engineered cell lines, and/or highly potent drugs for which a small dosage is efficacious. Reservoirs (26, 28) prepared according to this method and electrotransport devices (10) containing such reservoirs are also provided. im 1 wherein: after the first period of time, the ACD regains control over distributing of the calls that are routed to the first route point; the improvement further comprising before expiration of the first period of time, thirdly directing calls that are routed to the first route point to one of (a) the first route point and (b) a second route point that directs calls that are routed to the second route point to the first route point; and in response to the thirdly directing, the ACD routing the calls from the first route point to the one of (a) the first route point and (b) the second route point. 3. The improvement of claim 1 in a call center wherein the ACD gains control over distributing of the calls that are routed to the first route point to the call-receiving devices after the first period of time. 4. The improvement of claim 1 wherein: the first request is a request from a first device; the second request is a request from one of (c) the first device and a second device different from the first device; and secondly directing comprises directing the call to one of (d) the first device, (e) the second device, and (f) a third device different from the first and the second devices. 5. The improvement of claim 1 wherein: the first request is one of a call-hold and a call-park request; and the second request is one of a call-pickup and a call-transfer request. 6. In a call center having an automatic call distributor (ACD) for routing directed calls and a plurality of call-receiving devices, the improvement comprising: a first route point in the call center devoid of a queue statement that would direct calls routed to the first route point away from the first route point, so that the ACD loses control over distributing of the calls that are routed to the first route point for at least a first period of time; a first control entity that responds to a first request from a device of the call-receiving devices to which a call has been routed by directing the call from the call-receiving device to which the call has been routed to the route point to cause the ACD to route the call to the first route point, and that responds during at least the first period of time to a second request from a device of the call-receiving devices by directing the call from the first route point to a device of the call-receiving devices to cause the ACD to route the call to the device to which the call is directed. 7. The improvement of claim 6 wherein: after the first period of time the ACD regains control over distributing of the calls that are routed to the first route point; the improvement further comprising a second control entity that, before expiration of the first period of time, directs calls that are routed to the first route point to one of (a) the first route point and (b) a second route point that directs calls that are routed to the second route point to the first route point, to cause the ACD to route the calls to the one of (a) the first route point and (b) the second route point. 8. The improvement of claim 6 in a call center wherein the ACD gains control over distributing of the calls that are routed to the first route point to the call-receiving devices after the first period of time. 9. The improvement of claim 6 wherein: the first request is a request from a first device; the second request is a request from one of (c) the first device and a second device different from the first device; and the first control entity responds to the second request by directing the call to one of (d) the first device, (e) the second device, and (f) a third device different from the first ad the second devices. 10. The improvement of claim 6 wherein: the first request is one of a call-hold and a call-park request; and the second request is one of a call-pickup and a call-transfer request. 11. In a call center having an automatic call distributor (ACD) for routing directed calls and a plurality of