초록 ▼

An active substance matrix patch for controlled delivery of nonsteroidal antirheumatics to the skin, comprising a flexible cover layer and a water insoluble, pressure sensitively adhesive active substance matrix, wherein said adhesive matrix is free from mineral oils and tackifier resins and is comp

An active substance matrix patch for controlled delivery of nonsteroidal antirheumatics to the skin, comprising a flexible cover layer and a water insoluble, pressure sensitively adhesive active substance matrix, wherein said adhesive matrix is free from mineral oils and tackifier resins and is composed of a) from 25 to 90% by weight of synthetic framework polymers based on polyisobutylene, b) from 5 to 40% by weight of amorphous poly-α-olefin, c) from 10 to 60% by weight of an insoluble hydrophilic filler having an average particle size of less than 100 μm, and d) from 0.001 to 20% by weight of a drug.

대표청구항 ▼

1. An active matrix substance patch for controlled delivery of nonsteroidal antirheumatics to the skin, comprising a flexible cover layer and a water insoluble, pressure sensitive adhesive active substance matrix, wherein said adhesive matrix is free from mineral oils and tackifier resins and is com

1. An active matrix substance patch for controlled delivery of nonsteroidal antirheumatics to the skin, comprising a flexible cover layer and a water insoluble, pressure sensitive adhesive active substance matrix, wherein said adhesive matrix is free from mineral oils and tackifier resins and is composed of a) from 25 to 90% by weight of synthetic framework polymers based on polyisobutylene, b) from 5 to 40% by weight of amorphous poly-α-olefin, c) from 10 to 60% by weight of an insoluble hydrophilic filler having an average particle size of less than 100 μm, and d) from 0.001 to 20% by weight of a drug. 2. The patch as claimed in claim 1, wherein the matrix comprises poly-a-olefins in a concentration of from 5 to 20% by weight. 3. The patch as claimed in claim 1, wherein the polyisobutylene is composed of from 5 to 30% by weight of high molecular mass PIB, and from 20 to 60% by weight of low molecular mass PIB. 4. The patch as claimed in claim 1, wherein the filler is based on cellulose and its derivatives. 5. The patch as claimed in claim 1, wherein the matrix comprises a hydrophilic filler based on cellulose and its derivatives whose average particle size is in the range from 20 to 60 μm. 6. The patch as claimed in claim 1, wherein the matrix contains from 0.1 to 20% by weight of an active substance from the group of nonsteroidal antirheumatics. 7. The patch as claimed in claim 1, wherein permeation enhancing ingredients in the concentration range from 1.0 to 30% by weight, are added to the matrix. 8. A process for producing an active substance matrix patch as claimed in claim 1, wherein all components of the pressure sensitively adhesive matrix are homogenized in the melt without any addition of solvent. 9. The process as claimed in claim 8, wherein all components are processed in a continuous or batchwise process at a temperature below 100° C. 10. The patch as claimed in claim 6, wherein the matrix contains from 2 to 10% by weight, of an active substance selected from the group of nonsteroidal antirheumatics. 11. The patch as claimed in claim 6, wherein the nonstehoidal antirheumatic is selected from the group consisting of ibuprofen, ketoprofen, peroxicam, and diclofenac. 12. The patch as claimed in claim 7, wherein permeation enhancing ingredients in the concentration range from 10 to 25% by weight are added to the matrix.