초록 ▼

The present invention is directed to methods and devices for delivering an active agent formulation to the lung of a human patient. The active agent formulation may be in dry powder form, it may be nebulized, or it may be in admixture with a propellant. The active agent formulation is delivered to a

The present invention is directed to methods and devices for delivering an active agent formulation to the lung of a human patient. The active agent formulation may be in dry powder form, it may be nebulized, or it may be in admixture with a propellant. The active agent formulation is delivered to a patient at an inspiratory flow rate of less than 17 liters per minute. The bioavailability of the active agent was found to increase at these flow rates when compared to inspiratory flow rates of 17 liters per minute or more.

대표청구항 ▼

The present invention is directed to methods and devices for delivering an active agent formulation to the lung of a human patient. The active agent formulation may be in dry powder form, it may be nebulized, or it may be in admixture with a propellant. The active agent formulation is delivered to a

The present invention is directed to methods and devices for delivering an active agent formulation to the lung of a human patient. The active agent formulation may be in dry powder form, it may be nebulized, or it may be in admixture with a propellant. The active agent formulation is delivered to a patient at an inspiratory flow rate of less than 17 liters per minute. The bioavailability of the active agent was found to increase at these flow rates when compared to inspiratory flow rates of 17 liters per minute or more. mooth, or provided with parallel annular fins (14) or radial fins (15). 8. The solar thermoaccumulator according to claim 7, wherein at least one second reservoir (16) is coupled in an aligned and parallel position with the at least one first reservoir (9, 9'); with the reservoirs (9, 9', 16) being connected with each other by longitudinal slits (17) obtained in the coupling zone. 9. The solar thermoaccumulator according to claim 8, wherein the reservoirs (9, 9', 16) are coated with an insulating material (10). 10. The solar thermoaccumulator according to claim 4, wherein each of the heat accumulation bulbs or condensers (6) and the tubular tangs (11) are made from materials having a different coefficient of thermal expansion. 11. The solar thermoaccumulator according to claim 10, wherein the heat accumulation bulbs or condensers (6) are made from copper, and the tubular tangs (11) are made from steel. 12. The solar thermoaccumulator according to claim 11, wherein the tangs (11) have a surface (13) in touch with the liquid to be heated, the surface being either smooth, or provided with parallel annular fins (14) or radial fins (15). 13. The solar thermoaccumulator according to claim 12, wherein at least a second reservoir (16) is coupled in an aligned and parallel position with the at least one first reservoir (9, 9'); with the reservoirs (9, 9', 16) being connected with each other by longitudinal slits (17) obtained in the coupling zone. 14. The solar thermoaccumulator according to claim 13, wherein the reservoirs (9, 9', 16) are coated with an insulating material (10).