High density electrophoresis device and method
원문보기
IPC분류정보
국가/구분
United States(US) Patent
등록
국제특허분류(IPC7판)
G01N-027/26
G01N-027/447
출원번호
US-0616596
(2000-07-14)
발명자
/ 주소
Woudenberg, Timothy M.
Kowallis, Reid B.
출원인 / 주소
Applera Corporation
대리인 / 주소
Powers, Vincent M.
인용정보
피인용 횟수 :
63인용 특허 :
12
초록▼
The present invention provides, in one aspect, an apparatus for electrophoretic separation of analytes. In one aspect, the apparatus comprises a disc-shaped substrate defining (1) a central reservoir region, (2) a plurality of electrophoretic channels in fluid communication with, and emanating subst
The present invention provides, in one aspect, an apparatus for electrophoretic separation of analytes. In one aspect, the apparatus comprises a disc-shaped substrate defining (1) a central reservoir region, (2) a plurality of electrophoretic channels in fluid communication with, and emanating substantially radially from, the central reservoir region, the channels being coplanar with each other, and each channel having (i) a proximal end which is linked to the reservoir region, and (ii) a distal end, and preferably (3) for each channel, at least one chamber, and preferably three chambers, linked by a passageway in fluid communication with the distal end of that channel. Preferably, each passageway leads from each chamber in a direction that is initially away from the central reservoir region, whereby centrifugation of the substrate about a central axis that is perpendicular to the channels is effective to disperse liquid from the central reservoir region into the channels and chambers, such that any air bubbles in the chambers, channels, and passageways are forced towards the axis of rotation, when such liquid is present in the central reservoir region.
대표청구항▼
The present invention provides, in one aspect, an apparatus for electrophoretic separation of analytes. In one aspect, the apparatus comprises a disc-shaped substrate defining (1) a central reservoir region, (2) a plurality of electrophoretic channels in fluid communication with, and emanating subst
The present invention provides, in one aspect, an apparatus for electrophoretic separation of analytes. In one aspect, the apparatus comprises a disc-shaped substrate defining (1) a central reservoir region, (2) a plurality of electrophoretic channels in fluid communication with, and emanating substantially radially from, the central reservoir region, the channels being coplanar with each other, and each channel having (i) a proximal end which is linked to the reservoir region, and (ii) a distal end, and preferably (3) for each channel, at least one chamber, and preferably three chambers, linked by a passageway in fluid communication with the distal end of that channel. Preferably, each passageway leads from each chamber in a direction that is initially away from the central reservoir region, whereby centrifugation of the substrate about a central axis that is perpendicular to the channels is effective to disperse liquid from the central reservoir region into the channels and chambers, such that any air bubbles in the chambers, channels, and passageways are forced towards the axis of rotation, when such liquid is present in the central reservoir region. ar embodiment for the present invention is for personal computer keyboard microcontrollers.
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이 특허에 인용된 특허 (12)
Vesterberg Olof A. Y. (Saltsj-Duvns SEX), Apparatus for electrophoresis.
Mian Alec ; Kieffer-Higgins Stephen G. ; Corey George D., Devices and methods for using centripetal acceleration to drive fluid movement in a microfluidics system.
Adourian Aram S. ; Ehrlich Daniel J. ; Koutny Lance B. ; Matsudaira Paul T. ; Schmalzing Dieter R., Methods and apparatus for processing a sample of biomolecular analyte using a microfabricated device.
Moon, John A.; Putnam, Martin A.; Kersey, Alan D.; Fournier, David; Pinto, Joseph, Composition including an item and an encoded optical substrate and a method for identifying an item.
Fiering, Jason O.; Mescher, Mark J.; Pararas, Erin E.; Borenstein, Jeffrey T.; Sewell, William F.; Kujawa, Sharon G.; McKenna, Michael J.; Kim, Ernest S., Drug delivery apparatus.
Fiering, Jason O.; Mescher, Mark J.; Pararas, Erin E.; Borenstein, Jeffrey T.; Sewell, William F.; Kujawa, Sharon G.; McKenna, Michael J.; Kim, Ernest S., Drug delivery apparatus.
Kersey, Alan D.; Moon, John A.; Putnam, Martin A., Elongated microparticles having an optically detectable code configured to at least one of reflect or filter light.
Kersey, Alan; Moon, John A.; Putnam, Martin A., Holographically encoded elements for microarray and other tagging labeling applications, and method and apparatus for making and reading the same.
Moon, John A.; Putnam, Martin A.; Kersey, Alan; Fournier, David; Pinto, Joseph, Method and apparatus for drug product tracking using encoded optical identification elements.
Moon, John A.; Putnam, Martin A.; Kersey, Alan D.; Szczepanek, Paul, Method and apparatus for labeling using optical identification elements characterized by X-ray diffraction.
Ludowise, Peter D.; Whitman, David A.; Armantrout, Kyle C.; Exner, Maurice; Jacky, Lucien A. E.; Tabb, Michelle, Systems and methods for detecting the presence of a selected volume of material in a sample processing device.
Ludowise, Peter D.; Whitman, David A.; Armantrout, Kyle C.; Exner, Maurice; Jacky, Lucien A. E.; Tabb, Michelle, Systems and methods for detecting the presence of a selected volume of material in a sample processing device.
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