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Compositions and methods for the pulmonary delivery of aerosolized medicaments

IPC분류정보
국가/구분 United States(US) Patent 등록
국제특허분류(IPC7판)
  • A61K-009/12
  • A61K-009/14
출원번호 US-0616236 (2000-07-14)
발명자 / 주소
  • Platz, Robert M.
  • Patton, John S.
  • Foster, Linda
  • Eljamal, Mohammed
출원인 / 주소
  • Nektar Therapeutics
대리인 / 주소
    Evans, Susan T.Wilson, Mark A.Cagan, Felissa H.
인용정보 피인용 횟수 : 30  인용 특허 : 10

초록

According to the subject invention, dispersible dry powder pharmaceutical-based compositions are provided, including methods for their manufacture and dry powder dispersion devices. A dispersible dry powder pharmaceutical-based composition is one having a moisture content of less than about 10% by w

대표청구항

1. An aerosolizable, spray-dried powder formulation for pulmonary delivery comprising a growth hormone and a pharmaceutically acceptable carrier, wherein the powder comprises a plurality of particles having an average particle size of less than about 10 microns MMD and further wherein each particle

이 특허에 인용된 특허 (10)

  1. Ganderton David (Exeter GB2) Kassem Nuha M. (London GB2), Aerosol carriers.
  2. Srensen Hans Holmegaard (Virum DKX), Composition and method comprising growth hormone and leucine.
  3. Radhakrishnan Ramachandran (Fremont CA) Mihalko Paul J. (Fremont CA) Abra Robert M. (San Francisco CA), Method and apparatus for administering dehydrated liposomes by inhalation.
  4. Hirai Shin-ichiro (Kyoto JPX) Okada Hiroaki (Suita JPX) Yashiki Takatsuka (Takarazuka JPX), Pharmaceutical composition and its nasal or vaginal use.
  5. Christensen Thorkild,DKX ; Balschmidt Per,DKX ; S.o slashed.rensen Hans Holmegaard,DKX ; Olsen Ole Hvilsted,DKX ; Thim Lars,DKX, Pharmaceutical formulation.
  6. S.o slashed.rensen Hans Holmegaard,DKX ; Skriver Lars,DKX ; Hoelgaard Annie Rassing,DKX, Pharmaceutical formulation.
  7. S.o slashed.rensen Hans Holmegaard,DKX ; Skriver Lars,DKX ; Hoelgaard Annie Rassing,DKX, Pharmaceutical formulation.
  8. Srensen Hans H. (Virum DKX), Pharmaceutical formulation.
  9. Srensen Hans H. (Virum DKX), Pharmaceutical formulation.
  10. Sutton Andrew D.,GBX ; Johnson Richard A.,GBX ; Senior Peter J.,GBX ; Heath David,GBX, Spray-dried microparticles and their use as therapeutic vehicles.

이 특허를 인용한 특허 (30)

  1. Pipkin, James D.; Mosher, Gerold L.; Hecker, Douglas B., DPI formulation containing sulfoalkyl ether cyclodextrin.
  2. Pipkin, James D.; Mosher, Gerold L.; Hecker, Douglas B., DPI formulation containing sulfoalkyl ether cyclodextrin.
  3. Tarara, Thomas E.; Weers, Jeffry G.; Kabalnov, Alexey; Schutt, Ernest G.; Dellamary, Luis A., Engineered particles and methods of use.
  4. Tarara,Thomas E.; Weers,Jeffry G.; Kabalnov,Alexey; Schutt,Ernest G.; Dellamary,Luis A., Engineered particles and methods of use.
  5. Tarara, Thomas E.; Weers, Jeffry G.; Eldon, Michael A.; Narashimhan, Rangachari; Clark, Andrew, Formulation for pulmonary administration of antifungal agents, and associated methods of manufacture and use.
  6. Teo, Choon; Sun, Xianqiang; Wang, Xiaoyong, Method and system for producing high purity vancomycin hydrochloride.
  7. Patton, John S.; Foster, Linda S.; Platz, Robert M., Methods and compositions for pulmonary delivery of insulin.
  8. Bilzi, Roberto; Armanni, Angela; Rastelli, Roberto; Cocconi, Daniela; Musa, Rosella, Pharmaceutical formulations for dry powder inhalers comprising a low-dosage strength active ingredient.
  9. Weers, Jeffry G.; Tarara, Thomas E.; Dellamary, Luis A.; Riess, Jean G.; Schutt, Ernest G., Phospholipid-based powders for drug delivery.
  10. Weers, Jeffry G; Tarara, Thomas E; Dellamary, Luis A; Riess, Jean G; Schutt, Ernest G, Phospholipid-based powders for drug delivery.
  11. Wang, Zhaolin; Finlay, Warren H., Powder formation by atmospheric spray-freeze drying.
  12. Patton,John S., Pulmonary delivery of active fragments of parathyroid hormone.
  13. Tarara, Thomas E.; Weers, Jeffry G.; Venthoye, Geraldine, Pulmonary delivery of aminoglycoside.
  14. Tarara, Thomas E; Weers, Jeffry G; Venthoye, Maria Geraldine, Pulmonary delivery of aminoglycoside.
  15. Tarara, Thomas E.; Weers, Jeffrey G.; Kabalnov, Alexey; Schutt, Ernest G.; Dellamary, Luis A., Pulmonary delivery particles comprising an active agent.
  16. Weers, Jeffry G.; Schutt, Ernest G.; Dellamary, Luis A.; Tarara, Thomas E.; Kabalnov, Alexey, Respiratory dispersion for metered dose inhalers comprising perforated microstructures.
  17. Roser, Bruce J.; Kampinga, Jaap; Colaco, Camilo; Blair, Julian, Solid dose delivery vehicle and methods of making same.
  18. Roser, Bruce J.; Kampinga, Jaap; Colaco, Camilo; Blair, Julian, Solid dose delivery vehicle and methods of making same.
  19. Roser, Bruce J.; Kampinga, Jaap; Colaco, Camilo; Blair, Julian, Solid dose delivery vehicle and methods of making same.
  20. Fragale, Cynthia; Brueck, Daniel, Spray drying vancomycin.
  21. Fragale, Cynthia; Brueck, Daniel, Spray drying vancomycin.
  22. Fragale, Cynthia; Brueck, Daniel, Spray drying vancomycin.
  23. Weers, Jeffry G.; Schutt, Ernest G.; Dellamary, Luis; Tarara, Thomas E.; Kabalnov, Alexey, Stabilized preparations for use in metered dose inhalers.
  24. Dellamary, Luis A.; Reiss, Jean; Schutt, Ernest G.; Weers, Jeffry G.; Tarara, Thomas E., Stable metal ion-lipid powdered pharmaceutical compositions for drug delivery.
  25. Dellamary, Luis A.; Riess, Jean; Schutt, Ernest G.; Weers, Jeffry G.; Tarara, Thomas E., Stable metal ion-lipid powdered pharmaceutical compositions for drug delivery and methods of use.
  26. Dellamary, Luis A; Riess, Jean; Schutt, Ernest G; Weers, Jeffry G; Tarara, Thomas E, Stable metal ion-lipid powdered pharmaceutical compositions for drug delivery and methods of use.
  27. Mosher, Gerold L.; Pipkin, James D.; Hecker, Douglas B., Sulfoalkyl ether cyclodextrin compositions and methods of preparation thereof.
  28. Pipkin, James D.; Mosher, Gerold L.; Hecker, Douglas B., Sulfoalkyl ether cyclodextrin compositions and methods of preparation thereof.
  29. Pipkin, James D.; Mosher, Gerold L.; Hecker, Douglas B., Sulfoalkyl ether cyclodextrin compositions and methods of preparation thereof.
  30. Pipkin, James D.; Mosher, Gerold L.; Hecker, Douglas B., Sulfoalkyl ether cyclodextrin compositions and methods of preparation thereof.
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