Methods and compositions for systemically or locally administering by implantation a beneficial agent to a subject are described, and include, for example, compositions having burst indices of 8 or less for systemic applications and systems releasing 10% or less of the total dose of beneficial agent
Methods and compositions for systemically or locally administering by implantation a beneficial agent to a subject are described, and include, for example, compositions having burst indices of 8 or less for systemic applications and systems releasing 10% or less of the total dose of beneficial agent in the first 24 hours after implantation for local applications. The compositions include a biocompatible polymer, a biocompatible solvent having low water miscibility that forms a viscous gel with the polymer and limits water uptake by the implant, and a beneficial agent.
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Methods and compositions for systemically or locally administering by implantation a beneficial agent to a subject are described, and include, for example, compositions having burst indices of 8 or less for systemic applications and systems releasing 10% or less of the total dose of beneficial agent
Methods and compositions for systemically or locally administering by implantation a beneficial agent to a subject are described, and include, for example, compositions having burst indices of 8 or less for systemic applications and systems releasing 10% or less of the total dose of beneficial agent in the first 24 hours after implantation for local applications. The compositions include a biocompatible polymer, a biocompatible solvent having low water miscibility that forms a viscous gel with the polymer and limits water uptake by the implant, and a beneficial agent. barium sulfate, silicate, potassium aluminosilicate, hydrated alumina, an iron oxide pigment, lead chromate, lead molybdate, a cadmium pigment, a synthetic metal oxide mixture, Prussian blue, zinc yellow, basic zinc chromate, strontium chromate, red lead, copper oxide (I), calcium plumbate, basic lead silicochromate, white molybdate, modified barium metaborate, zinc phosphate and pearl essence. 13. A deodorant and absorbent product comprising a colored photocatalytic active carbon according to claim 9. tors," Materials Science and Engineering, B1(1988), pp. 9-13. Li et al., "Epitaxial La 0.67 Sr0.33 MnO3Magnetic Tunnel Junctions," J. Appl. Phys. 81(8), Apr. 15, 1997, pp. 5509-5511. O'Donnell et al., "Colossal Magnetoresistive Magnetic Tunnel Junctions Grown by Molecular-Beam Epitaxy," Appl. Physics Letters, vol. 76, No. 14, Apr. 3, 2000, pp. 1914-1916. Mikami et al., "Formation of Si Epi/MgO-Al2O3Epi./SiO3/Si and Its Epitaxial Film Quality," Fun
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이 특허에 인용된 특허 (44)
Dunn Richard L. ; Yewey Gerald L. ; Southard Jeffrey L. ; Urheim John E., Adjunctive polymer system for use with medical device.
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Polson Alan M. (Fort Collins CO) Swanbom Deryl D. (Fort Collins CO) Dunn Richard L. (Fort Collins CO) Cox Charles P. (Fort Collins CO) Norton Richard L. (Fort Collins CO) Lowe Bryan K. (Fort Collins , Biodegradable implant precursor.
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Dunn Richard L. (451 Boardwalk Dr. RLD ; Apt. 501 Fort Collins CO 80526) English James P. (2500 Melinda Cir. Birmingham AL 35214) Cowsar Donald R. (4657 Round Forest Dr. Birmingham AL 35213) Vanderbi, Biodegradable in-situ forming implants and methods of producing the same.
Dunn Richard L. (Fort Collins CO) English James P. (Birmingham AL) Cowsar Donald R. (Birmingham AL) Vanderbilt David D. (Birmingham AL), Biodegradable in-situ forming implants and methods of producing the same.
Dunn Richard L. (Fort Collins CO) English James P. (Birmingham AL) Cowsar Donald R. (Birmingham AL) Vanderbilt David P. (Birmingham AL), Biodegradable in-situ forming implants and methods of producing the same.
Dunn Richard L. (Fort Collins CO) Tipton Arthur J. (Fort Collins CO) Southard George L. (Fort Collins CO) Rogers Jack A. (Fort Collins CO), Biodegradable polymer composition.
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Lundgren Dan (Askims Kyrkvag 5 S-436 51 Hovas SEX) Gottlow Jan (Klintasgatan 5 S-422 44 Hisings Backa SEX) Mathisen Torbjorn (Bandhagsplan 9 S-132 24 Bandhagen SEX), Bioresorbable material and an article of manufacture made of such material for medical use.
Johnson OluFunmi Lily (Cambridge MA) Ganmukhi Medha M. (Wexford PA) Bernstein Howard (Cambridge MA) Auer Henry (Belmont MA) Khan M. Amin (Dowington PA), Composition for sustained release of human growth hormone.
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Zale Stephen E. (Hopkington MA) Burke Paul A. (Medford MA) Bernstein Howard (Cambridge MA) Brickner Avram (Brookline MA), Composition for sustained release of non-aggregated erythropoietin.
Stricker Herbert (Neckargemund DEX) Entenmann Gunther (Ingelheim am Rhein DEX) Kern Otto (Ingelheim am Rhein DEX) Mikhail Michel (Ingelheim am Rhein DEX) Zierenberg Bernd (Bingen DEX), Implantable, biodegradable system for releasing active substance.
Berggren Randall G. (Livermore CA) Enscore David J. (Saratoga CA) Marks Susan M. (San Jose CA) Osborne James L. (Mountain View CA) Wong Patrick S.-L. (Palo Alto CA) Roorda Wouter E. (Newark CA), Injectable drug delivery system and method.
Cowsar Donald R. (Birmingham AL) Dunn Richard L. (Fort Collins CO) Laughlin Thomas J. (Germantown TN), Method of producing zero-order controlled-released devices.
Damani Nalinkant C. (Cincinnati OH) Mohl Douglas C. (Fairfield OH) Singer ; Jr. Robert E. (Fairfield OH), Methods for aiding periodontal tissue regeneration.
Kent John S. (Cupertino CA) Lewis Danny H. (Birmingham AL) Sanders Lynda M. (Palo Alto CA) Tice Thomas R. (Birmingham AL), Microencapsulation of water soluble active polypeptides.
Bernstein Howard (Cambridge MA) Zhang Yan (Cambridge MA) Khan M. Amin (Downingtown PA) Tracy Mark A. (Arlington MA), Modulated release from biocompatible polymers.
Frappier Edward P. (Kernersville NC) Hull Ezekiel H. (Greensboro NC) Jackson L. Murl (Jamestown NC), Physically-modified degradable thermoplastic compositions.
Ramstack J. Michael (Lebanon OH) Herbert Paul F. (Wayland MA) Strobel Jan (Westchester OH) Atkins Thomas J. (Cincinnati OH), Preparation of biodegradable microparticles containing a biologically active agent.
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Gombotz Wayne R. (Lexington MA) Healy Michael S. (E. Bridgewater MA) Brown Larry R. (Newton MA), Very low temperature casting of controlled release microspheres.
Eliaz, Rom Ezer; Zhang, Yuanpeng; Rohloff, Catherine Manya; Weeks, Eric William; Junnarkar, Gunjan, Composition and dosage form comprising a particle formulation and suspending vehicle.
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Wright, Jeremy C.; Tamraz, Wilma; Leonard, John J.; Gibson, John W.; Branham, Keith E.; Sjobeck, Stefania; Boyd, Brooks; Rubino, Christopher M., Compositions and methods involving polymer, solvent, and high viscosity liquid carrier material.
Wright, Jeremy C.; Tamraz, Wilma; Leonard, John J.; Gibson, John W.; Branham, Keith E.; Sjobeck, Stefania; Boyd, Brooks; Rubino, Christopher M., Compositions and methods involving polymer, solvent, and high viscosity liquid carrier material.
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Alessi, Thomas R.; Leung, Karling Alice; Mercer, Ryan D.; Negulescu, Cristina G.; Rohloff, Catherine M.; Yang, Bing, Devices, formulations, and methods for delivery of multiple beneficial agents.
Wright, Jeremy C.; Tamraz, Wilma; Leonard, John J.; Gibson, John W.; Branham, Keith E.; Sjobeck, Stefania; Boyd, Brooks; Rubino, Christopher M., Injectable controlled release composition comprising high viscosity liquid carrier.
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