초록 ▼

Methods and compositions for systemically or locally administering by implantation a beneficial agent to a subject are described, and include, for example, compositions having burst indices of 8 or less for systemic applications and systems releasing 10% or less of the total dose of beneficial agent

Methods and compositions for systemically or locally administering by implantation a beneficial agent to a subject are described, and include, for example, compositions having burst indices of 8 or less for systemic applications and systems releasing 10% or less of the total dose of beneficial agent in the first 24 hours after implantation for local applications. The compositions include a biocompatible polymer, a biocompatible solvent having low water miscibility that forms a viscous gel with the polymer and limits water uptake by the implant, and a beneficial agent.

대표청구항 ▼

Methods and compositions for systemically or locally administering by implantation a beneficial agent to a subject are described, and include, for example, compositions having burst indices of 8 or less for systemic applications and systems releasing 10% or less of the total dose of beneficial agent

Methods and compositions for systemically or locally administering by implantation a beneficial agent to a subject are described, and include, for example, compositions having burst indices of 8 or less for systemic applications and systems releasing 10% or less of the total dose of beneficial agent in the first 24 hours after implantation for local applications. The compositions include a biocompatible polymer, a biocompatible solvent having low water miscibility that forms a viscous gel with the polymer and limits water uptake by the implant, and a beneficial agent. barium sulfate, silicate, potassium aluminosilicate, hydrated alumina, an iron oxide pigment, lead chromate, lead molybdate, a cadmium pigment, a synthetic metal oxide mixture, Prussian blue, zinc yellow, basic zinc chromate, strontium chromate, red lead, copper oxide (I), calcium plumbate, basic lead silicochromate, white molybdate, modified barium metaborate, zinc phosphate and pearl essence. 13. A deodorant and absorbent product comprising a colored photocatalytic active carbon according to claim 9. tors," Materials Science and Engineering, B1(1988), pp. 9-13. Li et al., "Epitaxial La 0.67 Sr0.33 MnO3Magnetic Tunnel Junctions," J. Appl. Phys. 81(8), Apr. 15, 1997, pp. 5509-5511. O'Donnell et al., "Colossal Magnetoresistive Magnetic Tunnel Junctions Grown by Molecular-Beam Epitaxy," Appl. Physics Letters, vol. 76, No. 14, Apr. 3, 2000, pp. 1914-1916. Mikami et al., "Formation of Si Epi/MgO-Al2O3Epi./SiO3/Si and Its Epitaxial Film Quality," Fun