초록 ▼

An apparatus for exchanging gases in a liquid is provided. Preferably, the apparatus comprises a housing, a first inlet, a gas exchange medium, a separator, a first outlet, and a second inlet and outlet. The apparatus may further comprise a circumferential collection gap that collects liquid from th

An apparatus for exchanging gases in a liquid is provided. Preferably, the apparatus comprises a housing, a first inlet, a gas exchange medium, a separator, a first outlet, and a second inlet and outlet. The apparatus may further comprise a circumferential collection gap that collects liquid from the gas exchange medium and directs it toward the first outlet. Also, the apparatus may further comprise a compliant chamber positioned near the first inlet. The compliant chamber reduces the overall impedance of the apparatus. The apparatus is particularly well-suited for use as an implantable, artificial lung. In this embodiment, the liquid comprises blood and the apparatus exchanges supplied oxygen for waste carbon dioxide.

대표청구항 ▼

An apparatus for exchanging gases in a liquid is provided. Preferably, the apparatus comprises a housing, a first inlet, a gas exchange medium, a separator, a first outlet, and a second inlet and outlet. The apparatus may further comprise a circumferential collection gap that collects liquid from th

An apparatus for exchanging gases in a liquid is provided. Preferably, the apparatus comprises a housing, a first inlet, a gas exchange medium, a separator, a first outlet, and a second inlet and outlet. The apparatus may further comprise a circumferential collection gap that collects liquid from the gas exchange medium and directs it toward the first outlet. Also, the apparatus may further comprise a compliant chamber positioned near the first inlet. The compliant chamber reduces the overall impedance of the apparatus. The apparatus is particularly well-suited for use as an implantable, artificial lung. In this embodiment, the liquid comprises blood and the apparatus exchanges supplied oxygen for waste carbon dioxide. vol. 60, 2001, pp. 101-110. P.H.G. Sharpe et al., "Real Time Dosimetry Measurements at an Industrial Irradiation Plant," Radiation Physics and Chemistry, vol. 57, 2000, pp. 687-690. W.L. McLaughlin et al., "Preservation of Food by Ionizing Radiation," Chapter 8, vol. I, 1982, pp. 189-245. A. Brynjolfsson, "Cobalt-60 Irradiator Designs," pp. 145-172, prior art. J. P. Farrell et al., "Sterilization--Selecting a Radiation Sterilization Method," Medical Device & Diagnostic Industry, Aug. 1995, pp. 82-90. AABB FDA Liaison Meeting, ABC Newsletter, p. 14 (Dec. 12, 1997). Alladine, M.F. et al., γ-Radiation Damage to Starr-Edwards Valves, The Lancet, 1:594 (1968). Alper, T. et al., Protection by Anoxia of the Scrapie Agent and some DNA and RNA Viruses Irradiated as Dry Preparations, J. Gen. Virol., 3:157-166 (1968). Alper, T. et al., Does the Agent of Scrapie Replicate Without Nucleic Acid?, Nature, 214:764-766 (1967). Alper, T. et al., The Exceptionally Small Size of the Scrapie Agent, Biochemical and Biophysical Research Communications, 22:278-284 (1996). Alper, T. et al., The Scrapie Agent: Evidence Against its Dependence For Replication on Intrinsic Nucleic Acid, J. Gen. Virol., 41:503-516 (1978). Akkus, O. et al., Fracture Resistance of Gamma Radiation Sterilized Cortical Bone Allografts, J. Orthapaedic Research, 19:927-934 (2001) (Elsevier Science Ltd.). Aparicio, S.R. et al., Light and Electron Microscopy Studies on Homograft and Heterograft Heart Valves, J. Path., 115:147-162 (1975). Baksa, J. et al., The Use of Pig's Skin (xenograft) for the Treatment of Burns, Magyar Traumatologia, 19:138-145 (1976). Baldwin, M.L. et al., Irradiation of Blood Components, pp. 10-78 (1992) (American Association of Blood Banks). Baquey, C. et al.., Radiosterilization of Albuminated Polyester Prostheses, Biomaterials, 8:185-189 (1987). Bassin, R.H. et al., Abrogation of Fv-1bRestriction With Murine Leukemia Viruses Inactivated by Heat or by Gamma Irradiation, Journal of Virology, 26:306-315 (1978) (American Society for Microbiology). Beauregard, G. et al., Temperature Dependence of the Radiation Inactivation of Proteins, Analytical Biochemistry, 150:117-120 (1985) (Academic Press Inc.). Bedrossian Jr., E.H. et al., HIV and Banked Fascia Lata, Ophthalmic Plastic and Reconstructive Surgery, 7:284-288 (1991) (Raven Press Ltd.). Belov, A.A. et al., The Influence of γ-Radiation on Enzyme Activity of Collalitin in the Process of Storage, Radiobiologiia, 30:519-521 (1990). Bingci, L., Mouse Antibody Response Following Repetitive Injections of Gamma-Irradiated Human Placenta Collagen, Chinese Medical Sciences Journal, 9:100-103 (1994). Blakeslee, S., Lack of Oversight in Tissue Donation Raising Concerns, The New York Times, Late Edition, pp. 1, 22 (Jan. 20, 2002) (http://query.nytimes.com). Blanchy, B.B. et al., Immobilization of Factor VIII on Collagen Memb ranes, J. Biomedical Materials Research, 20:469-479 (1986) (John Wiley & Sons, Inc.). Block, S.S., Disinfection, Sterilization, and Preservation,, Fourth Edition, pp. 31-33 (1991) (Lea & Febiger) (Philadelphia). Bogers, A.J.J.C. et al., Long-Term Results of the Gamma-Irradiation-Preserved Homograft Monocusp for Transannular Reconstruction of the Right-Ventricular Outflow Tract in Tetralogy of Fallot, Thorac. Cardiovasc. Surgeon, 42:337-339 (1994) (Georg Thieme Verlag Stuttgart). Borisova, E.A. et al., Protein Degradation During Interphase Death of Thymocytes induced by Radation and Dexamethasone, Radiobiologiia, 30:517-519 (1990). Boyer, T.D. et al., Radiation Inactivation of Microsomal Glutathione S-Transferase, The Journal of Biological Chemistry, 261:16963-16968 (1986). Brown, D.R. et al., Antioxidant Activity Related to Copper Binding of Native Prion Protein, J. Neurochem., 76:69-76 (2001) (Int'l Society for Neurochem.). Brown, P. et al., The Distribution of Infectivity in Blood Components and Plasma Derivatives in Experimental Models of Transmissible Spon