IPC분류정보
국가/구분 |
United States(US) Patent
등록
|
국제특허분류(IPC7판) |
|
출원번호 |
US-0860403
(1997-06-23)
|
우선권정보 |
GB-19940026379 (1994-12-23) |
국제출원번호 |
PCT/GB95/03016
(1995-12-21)
|
국제공개번호 |
WO96/20022
(1996-07-04)
|
발명자
/ 주소 |
- Bellhouse, Brian John
- Bell, John
|
출원인 / 주소 |
- PowderJect Research Limited
|
대리인 / 주소 |
|
인용정보 |
피인용 횟수 :
12 인용 특허 :
11 |
초록
▼
A needleless syringe comprising a body containing a lumen, an upstream end of which is, or is arranged to be, connected to a source of gaseous pressure which can suddenly be released into the lumen; the downstream end of the lumen terminating behind a bistable diaphragm which is movable between an i
A needleless syringe comprising a body containing a lumen, an upstream end of which is, or is arranged to be, connected to a source of gaseous pressure which can suddenly be released into the lumen; the downstream end of the lumen terminating behind a bistable diaphragm which is movable between an inverted position in which it presents outwardly of the body a concavity for containing particles of a therapeutic agent, and an everted, outwardly convex, position; the arrangement being such that, in use, when gas under pressure is released into the lumen, the diaphragm will snap over from its inverted to its everted position and catapult the particles outwardly.
대표청구항
▼
A needleless syringe comprising a body containing a lumen, an upstream end of which is, or is arranged to be, connected to a source of gaseous pressure which can suddenly be released into the lumen; the downstream end of the lumen terminating behind a bistable diaphragm which is movable between an i
A needleless syringe comprising a body containing a lumen, an upstream end of which is, or is arranged to be, connected to a source of gaseous pressure which can suddenly be released into the lumen; the downstream end of the lumen terminating behind a bistable diaphragm which is movable between an inverted position in which it presents outwardly of the body a concavity for containing particles of a therapeutic agent, and an everted, outwardly convex, position; the arrangement being such that, in use, when gas under pressure is released into the lumen, the diaphragm will snap over from its inverted to its everted position and catapult the particles outwardly. capillaries normally imparting to the skin a pink color is depressed by a pressure which is sufficient to expel blood from the capillaries while maintaining normal flow in the veins, said pressure causing the skin to blanch until the skin exhibits a white color, the said pressure being released when a point of maximum blanching is reached to permit blood to flow back to the capillaries at a rate that depends on the condition of the patient to cause the skin to regain its natural pink color; said instrument comprising: i) means including a color sensor trained on the skin area when exposed to light to generate a signal having a magnitude which is a function of light reflected by the skin area whose intensity depends on the natural color of the skin area; ii) means responsive to said signal before pressure is applied to the skin area to determine its natural pink color to establish a reference base for the test to follow; and iii means responsive to said signal when pressure is applied to said skin during the test to measure the time elapsing from a starting point in time when the depressed skin is at its maximum blanching value of white, and the pressure applied thereon is then released to cause the capillaries to proceed to fill with blood, to a final point in time when the skin recovers its natural pink color as established by the reference base, whereby the CFT measurement is an index to whether the patient is suffering from a shock-related condition, and to the severity of this condition. 2. An instrument as set forth in claim 1, further including a temperature sensor responsive to heat radiating from the skin area to generate a temperature signal that reflects the existing temperature of the skin area, and means to factor into the CFT measurement the temperature signal to compensate the CFT measurement for the effect of skin temperature thereon. 3. An instrument as in claim 2, in which the temperature sensor is a thermometer placed on the skin area to produce a signal whose magnitude depends on the existing skin temperature. 4. An instrument as in claim 1, wherein the color sensor means includes a video camera responsive to light reflected from the skin area to yield an image signal whose character depends on an existing skin color. 5. An apparatus as in claim 1, in which the color sensor means includes means to illuminate the skin area with modulated light from a light source, and a pulsed light reflected therefrom is intercepted by a photodetector which yields a signal that depends on an existing skin color. 6. An instrument as set forth in claim 1, further including means to apply pressure to said skin area and means to control the magnitude and/or duration of the pressure so as to apply to the skin area the minimum amount of pressure necessary to cause the skin to exhibit a white color. 7. A method for the diagnosis of a shock-related state in a patient by measuring the filling time of blood vessels subjacent to skin area of the patient, comprising the steps of: illuminating the area which is to be gauged for color with a modulated light from a light source, filtering out background noises to obtain a base-line measurement, and determining the filling time of blood vessels in said area by comparison of a current color of the area with the base-line measurement. 8. A method according to claim 7, comprising: i) illuminating the area having an original color with modulated light from a light source; ii) intercepting light reflected from the area with a light sensor, said light sensor producing a first signal having a magnitude which corresponds to the color of said area, said color representing the level of reflection; iii) filtering said first signal for rejecting unwanted signals derived from interfering light, and producing a second signal whose amplitude is proportional to the amplitude of said filtered first signal; iv) storing the amplitude value of said second signal which corresponds to said or
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