초록 ▼

A method for sampling of a substance from a subject is provided, which comprises placing one or more sampling chambers on a collection site on a tissue surface on the subject; conducting electric current through the tissue to extract a substance from the subject in a first direction in one or more s

A method for sampling of a substance from a subject is provided, which comprises placing one or more sampling chambers on a collection site on a tissue surface on the subject; conducting electric current through the tissue to extract a substance from the subject in a first direction in one or more sampling chambers that functions alternatively as both an anode and cathode during the course of the method; reversing the polarity to cause direct current to flow in second direction opposite the first direction; and analyzing the sampling chamber or chambers for the concentration of a substance or a substance metabolite. There is also provided a device for sampling of a substance from an organism on continuously or intermittently using alternating polarity method based on the application of low intensity electric fields of alternating polarity across the skin (iontophoresis) to enhance the transport of a substance (such as glucose, lactic acid, pyruvic acid, and the like) from body tissues to a sampling chamber. The device comprises an electrical power supply; a transdermal system that contains one or more sampling chambers that function as both anode and cathode during the course of sampling; a means to alternates or reverses the polarity during the iontophoretic sampling; and means for analyzing for the concentration of a substance or a substance metabolite.

대표청구항 ▼

A method for sampling of a substance from a subject is provided, which comprises placing one or more sampling chambers on a collection site on a tissue surface on the subject; conducting electric current through the tissue to extract a substance from the subject in a first direction in one or more s

A method for sampling of a substance from a subject is provided, which comprises placing one or more sampling chambers on a collection site on a tissue surface on the subject; conducting electric current through the tissue to extract a substance from the subject in a first direction in one or more sampling chambers that functions alternatively as both an anode and cathode during the course of the method; reversing the polarity to cause direct current to flow in second direction opposite the first direction; and analyzing the sampling chamber or chambers for the concentration of a substance or a substance metabolite. There is also provided a device for sampling of a substance from an organism on continuously or intermittently using alternating polarity method based on the application of low intensity electric fields of alternating polarity across the skin (iontophoresis) to enhance the transport of a substance (such as glucose, lactic acid, pyruvic acid, and the like) from body tissues to a sampling chamber. The device comprises an electrical power supply; a transdermal system that contains one or more sampling chambers that function as both anode and cathode during the course of sampling; a means to alternates or reverses the polarity during the iontophoretic sampling; and means for analyzing for the concentration of a substance or a substance metabolite. . An analysis apparatus as claimed in claim 1, further comprising a depth setting system to control the focus depth of the excitation beam and/or the monitoring beam. 8. An analysis apparatus as claimed in claim 7, wherein the depth setting system is arranged to control variation of an angle of incidence of the monitoring beam on the target region. 9. A method for spectral non-invasive analysis of a composition of an object comprising the steps of: imaging a target region, during a monitoring period; exciting the target region with an excitation beam during an excitation period; and if the target region moves, directing the excitation beam onto the target region during an overlap period of the excitation period and the monitoring period. 10. A method as claimed in claim 9, further comprising the step of directing a monitoring beam onto the target region. 11. A method as claimed in claim 9, further comprising the steps of generating an error signal representing motion of the target region; and controlling the excitation beam on the basis of the error signal. 12. A method as claimed in claim 10, further comprising the steps of generating an error signal representing motion of the target region; and controlling the monitoring beam on the basis of the error signal. 13. A method as claimed in claim 12, further comprising the steps of receiving scattered radiation generated by the excitation beam; and deriving the error signal from the scattered radiation. 14. A method as claimed in claim 9, further comprising the step of controlling a focus depth of the excitation beam and/or the monitoring beam. 15. A method as claimed in claim 14, further comprising the step of controlling variation of an angle of incidence of the monitoring beam on the target region.