초록

A device for measuring a volume of liquid drug. The device includes a first chamber containing liquid drug, a measurement chamber in liquid communication with the first chamber, and a measurement assembly.

대표청구항 ▼

A device for measuring a volume of liquid drug. The device includes a first chamber containing liquid drug, a measurement chamber in liquid communication with the first chamber, and a measurement assembly. ltrasound transmission member extending longitudinally through said catheter body and attached

A device for measuring a volume of liquid drug. The device includes a first chamber containing liquid drug, a measurement chamber in liquid communication with the first chamber, and a measurement assembly. ltrasound transmission member extending longitudinally through said catheter body and attached at the distal end thereof to the distal tip member for transmitting ultrasound energy to the distal tip member, a medicament infusion lumen extending longitudinally through said catheter body and opening through at least one medicament outlet aperture formed in the distal tip member and oriented radially outward in relation to the longitudinal axis of said catheter body; advancing the distal end of said catheter to a desired operative position relative to the obstruction to be ablated; generating ultrasonic energy at a location outside the catheter body; coupling said generated ultrasonic energy to the ultrasound transmission member at the proximal end of the catheter body; passing ultrasonic energy through said ultrasound transmission member to the distal tip member at the distal end of said catheter such that the distal end of said catheter will undergo ultrasonic vibration at a frequency which will result in ablation of said obstruction; and passing a flow of medicament through said medicament infusion lumen and out of said radially-oriented medicament outlet aperture formed in the distal tip member concurrently with the delivery of said ultrasonic energy through said catheter. 2. The method of claim 1 wherein the step of passing a flow of medicament further comprises: delivering a thrombolytic agent through said catheter. 3. The method of claim 2 wherein said thrombolytic agent is selected from the group consisting of: streptokinase; urokinase; tissue plasminogen activator; and possible combinations thereof. 4. The method of claim 1 wherein the step of passing a flow of medicament comprises: delivering an anticoagulant agent through said catheter. 5. The method of claim 4 wherein said anticoagulant agent is heparin. 6. A method for ultrasonic ablation of matter from an anatomical passageway of a mammalian body and for concomitant delivery of a liquid medicament, said method comprising the steps of: inserting into the mammalian body distal end first an ultrasound delivery/medicament infusion catheter comprising an elongate flexible catheter body having a longitudinal axis, a proximal end and a distal end, a distal tip member attached to the distal end of the catheter body, an ultrasound transmission member extending longitudinally through said catheter body and attached at the distal end thereof to the distal tip member for transmitting ultrasound energy to the distal tip member, a medicament infusion lumen extending longitudinally through said catheter body and opening through at least one medicament outlet aperture formed in the distal tip member and oriented radially outward in relation to the longitudinal axis of said catheter body; advancing the distal end of said catheter to a desired operative position relative to the obstruction be ablated; generating ultrasonic energy at a location outside the catheter body; coupling said generated ultrasonic energy to the ultrasound transmission member at the proximal end of the catheter body; passing a flow of medicament through said medicament infusion lumen and out of said radially-oriented medicament outlet aperture formed in the distal tip member; and passing sufficient ultrasonic energy through said ultrasound transmission member to the distal tip member at the distal end of said catheter concurrently with the delivery of said medicament through said catheter such that the distal end of said catheter will undergo ultrasonic vibration at a frequency that will result in ablation of said obstruction and that will result in the thorough dissemination of said medicament. 7. The method of claim 6 wherein the step of passing ultrasonic energy through said ultrasound transmission member comprises passing sufficient ultrasonic energy to the distal tip member at the distal end of said catheter such that the medicament effectiveness upon adjacent tissue acte