IPC분류정보
국가/구분 |
United States(US) Patent
등록
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국제특허분류(IPC7판) |
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출원번호 |
US-0556537
(2000-04-24)
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발명자
/ 주소 |
- Hatcher, Thomas James
- Grinberg, Aleksandr
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출원인 / 주소 |
- Pharmacopeia Drug Discovery Inc.
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대리인 / 주소 |
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인용정보 |
피인용 횟수 :
14 인용 특허 :
5 |
초록
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A single channel reformatter having a syringe that is movable along a z-axis by a z-positioner. A x-y positioner is capable of positioning any well of a source plate having a plurality of wells, and of positioning any well of a destination plate having a plurality of wells, beneath the syringe. Liqu
A single channel reformatter having a syringe that is movable along a z-axis by a z-positioner. A x-y positioner is capable of positioning any well of a source plate having a plurality of wells, and of positioning any well of a destination plate having a plurality of wells, beneath the syringe. Liquid from a well of the source plate is aspirated by the syringe and dispensed into one or more wells of the destination plate. Since the syringe does not move in the x-y plane, it is advantageously integrated into a wash system that cleanses it between liquid transfer operations. The drive element that actuates the syringe to aspirate and dispense during liquid transfer operations is advantageously used to drive the wash cycle. In a method according to present invention for controlling the reformatting operation, well-to-well links are specified, a preferred execution order for executing the specified links is determined, and the specified links are executed in the preferred order.
대표청구항
▼
A single channel reformatter having a syringe that is movable along a z-axis by a z-positioner. A x-y positioner is capable of positioning any well of a source plate having a plurality of wells, and of positioning any well of a destination plate having a plurality of wells, beneath the syringe. Liqu
A single channel reformatter having a syringe that is movable along a z-axis by a z-positioner. A x-y positioner is capable of positioning any well of a source plate having a plurality of wells, and of positioning any well of a destination plate having a plurality of wells, beneath the syringe. Liquid from a well of the source plate is aspirated by the syringe and dispensed into one or more wells of the destination plate. Since the syringe does not move in the x-y plane, it is advantageously integrated into a wash system that cleanses it between liquid transfer operations. The drive element that actuates the syringe to aspirate and dispense during liquid transfer operations is advantageously used to drive the wash cycle. In a method according to present invention for controlling the reformatting operation, well-to-well links are specified, a preferred execution order for executing the specified links is determined, and the specified links are executed in the preferred order. erein said step of computing said N-2 remaining positions for the ablative elements comprises computing N-2 ablative elements about the prostate periphery. 6. The computer system of claim 1, wherein said step of computing the number and location of ablative elements comprises computing the number and location of a set of cryoprobes. 7. The computer system of claim 1, wherein said step of computing the number and location of ablative elements comprises computing the number and location of a set of radioactive seeds. 8. The computer system of claim 1, wherein said step of computing the number and location of ablative elements comprises computing the number and location of a set of radio frequency devices. 9. The computer system of claim 1, wherein said step of computing the number and location of ablative elements comprises computing the number and location of a set of microwave devices. 10. The computer system of claim 1, wherein said step of computing the number and location of ablative elements comprises computing the number and location of a set of laser devices. 11. The computer system of claim 1, wherein said step of computing the number and location of ablative elements comprises computing the number and location of a set of high intensity focused ultrasound devices. 12. The computer system of claim 1, wherein said treatment zone comprises a plurality of treatment sections. 13. The computer system of claim 1, wherein said step of utilizing said determined dimensions of the prostate and treatment zone comprises the steps of: computing a distance (b) between the ablative elements so that the ablative elements are placed approximately equidistant from each other in said treatment zone; computing a first position for placement of a first ablative element based on the location of the center of the urethra; computing a second position for placement of a second ablative element, the second position being at said distance, b, from said first position and a distance a from the prostate periphery, wherein a is approximately 1/2 b; and, computing N-2 remaining positions about the prostate periphery in substantially the same manner as said second position was computed, where N is the number of ablative elements. 14. A computer system for the focal treatment of prostate cancer, said computer system including a display for assisting a surgeon in placing cryoprobes in the prostate of a human patient, wherein the cryoprobes are inserted through the skin of the perineal area of the patient and into the prostate, the display being adapted to display images of the prostate, said computer system being programmed with software capable of performing the following steps: determining the width of the prostate; determining the height of the prostate; determining the location of the center of the urethra; determining a side of the prostate that is required to be treated, said side being defined as the treatment zone, said treatment zone being determined to include only one neurovascular bundle of the prostate and exclude the other neurovascular bundle of the prostate; determining the number of cryoprobes (N) needed to freeze said treatment zone; computing an distance (b) between the cryoprobes so that the cryoprobes are placed approximately equidistant from each other in said treatment zone; computing an first position for placement of a first cryoprobe based on the location of the center of the urethra; computing an second position for placement of a second cryoprobe, the second position being at said distance, b, from said first position and a distance a from the prostate boundary, wherein a is approximately 1/2 b; and, computing N-2 remaining positions in substantially the same manner as said second position was determined. 15. A system for the focal treatment of prostate cancer, comprising: a) a computer guidance system including a display for assisting a surgeon in placing ablative elements in the prostate of a human p
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