An electrospray ionization device is provided that includes one or more electrospray needles and an ion sampling device. Each needle has a distal end for receiving a sample, a tip for spraying the sample in fluid communication with the distal end, and an electrical contact for contacting at least so
An electrospray ionization device is provided that includes one or more electrospray needles and an ion sampling device. Each needle has a distal end for receiving a sample, a tip for spraying the sample in fluid communication with the distal end, and an electrical contact for contacting at least some portion of sample therein. The ion sampling device has an entrance, an exit, and an interior in fluid communication with the entrance and the exit, and is located in proximity to the tip or tips of the one or more electrospray needles. The entrance defines an opening that has a larger area than an opening defined by the exit. The ion sampling device also has a counter-electrical contact. The electrospray ionization device further comprises means for generating an electrical potential difference between the counter-electrical contact and the electrical contact(s) of the one or more electrospray needles.
대표청구항▼
An electrospray ionization device is provided that includes one or more electrospray needles and an ion sampling device. Each needle has a distal end for receiving a sample, a tip for spraying the sample in fluid communication with the distal end, and an electrical contact for contacting at least so
An electrospray ionization device is provided that includes one or more electrospray needles and an ion sampling device. Each needle has a distal end for receiving a sample, a tip for spraying the sample in fluid communication with the distal end, and an electrical contact for contacting at least some portion of sample therein. The ion sampling device has an entrance, an exit, and an interior in fluid communication with the entrance and the exit, and is located in proximity to the tip or tips of the one or more electrospray needles. The entrance defines an opening that has a larger area than an opening defined by the exit. The ion sampling device also has a counter-electrical contact. The electrospray ionization device further comprises means for generating an electrical potential difference between the counter-electrical contact and the electrical contact(s) of the one or more electrospray needles. nd direct-current compensation voltage, to at least one of the two electrodes of the second analyzer, to form an electric field therebetween, the second asymmetric waveform for effecting a difference in net displacement between the ions in the time of one cycle of the applied second asymmetric waveform; and, setting the second compensation voltage for effecting the second separation of the ions to selectively transmit the second subset of the ions within the second analyzer. 8. A method according to claim 7 comprising the steps of: providing a gas flow within the second analyzer; and, adjusting the gas flow within the second analyzer so as to trap the selectively transmitted second subset of the ions within and proximate the trapping region of the second analyzer. 9. A method according to claim 8 comprising the step of applying an extraction voltage at the second ion outlet for extracting the accumulated ions from the trapping region of the second analyzer. 10. A method according to claim 7 wherein the second asymmetric waveform is a different asymmetric waveform than the first asymmetric waveform. 11. A method according to claim 1 comprising the step of: providing conditions within the second analyzer for effecting a second separation of ions therein, to support selective transmission of the second subset of the ions within the second analyzer. 12. A method according to claim 11 wherein the second analyzer comprises a FAIMS analyzer defined by a space between at least two spaced apart electrodes and wherein the step of providing conditions comprises the steps of: providing a second asymmetric waveform for effecting a difference in net displacement between the ions in the time of one cycle of the applied second asymmetric waveform and a second direct-current compensation voltage to at least an electrode of the second analyzer to form an electric field; and, setting the second compensation voltage for effecting the second separation of the ions to support selective transmission of the second subset of the ions within the second analyzer. 13. A method according to claim 12 comprising the steps of: providing a gas flow within the second analyzer and adjusting the gas flow within the second analyzer so as to trap the selectively transmitted second subset of the ions within and near a three-dimensional region of space within or proximate the trapping region of the second analyzer. 14. A method according to claim 13 comprising the step of: accumulating the selectively transmitted ions within the three-dimensional region during a period of time. 15. A method according to claim 13 comprising the additional step of applying an extraction voltage within or proximate the second analyzer for extracting the accumulated ions from the trapping region of the second analyzer. 16. A method according to claim 11 wherein the second analyzer is an ion trapping mass spectrometer including a ring electrode and a first and a second end-cap electrode. 17. A method according to claim 16 wherein the step of providing conditions within the second analyzer comprises the steps of: applying at least one of a symmetric radio-frequency potential and a direct-current potential across the ring electrode and the first and second end-cap electrodes, for trapping the first subset of the ions within a three-dimensional region of space within or proximate the second analyzer; and, varying the direct-current potential for effecting the second separation of the ions to selectively trap the second subset of the ions within or proximate the second analyzer. 18. A method according to claim 11 wherein the second analyzer is an analyzer selected from a radio frequency quadrupole ion trap, an FT ion cyclotron resonance mass spectrometer, and a penning trap. 19. A method according to claim 7 comprising the steps of: providing a gas cell between the first analyzer and the second analyzer, the gas cell having an ion inlet and an ion outlet, the ion inle t for receiving ions from the first analyzer and the ion outlet for providing ions to the second analyzer, the gas cell having a gas inlet and a gas outlet for providing a gas flow through the gas cell and out the gas outlet; and, providing at least a gas within the gas cell for interacting with the ions flowing therethrough. 20. A method according to claim 19 wherein the gas is selected from a group including: a gas for reacting chemically with the ions; a collision gas for inducing fragmentation of the ions; a gas for desolvating the ions; and, a gas for forming at least a complex with the ions in the gas phase. 21. An apparatus for trapping ions comprising: a) a first analyzer comprising two spaced apart electrodes defining a first analyzer region therebetween, the first analyzer region having a first ion inlet for receiving ions including a first ionic species and a second ionic species for introduction into the first analyzer region and a first ion outlet for providing ions from the first analyzer region; b) a second analyzer in fluid communication with the first analyzer and disposed for coupling ions provided therefrom, the second analyzer comprising two spaced apart electrodes defining a second analyzer region therebetween, the second analyzer region in communication with a second ion inlet for receiving ions from the first analyzer region for introduction into the second analyzer region, and a second ion outlet for providing ions from the second analyzer region; c) a first voltage source for providing a first asymmetric waveform and a first direct-current compensation voltage to at least one of the two spaced apart electrodes of the first analyzer, to form a first electric field therebetween, the first electric field for, in use, effecting a difference in net displacement between the ions in the time of one cycle of the applied first asymmetric waveform and the first compensation voltage for, use, effecting a first separation of the ions by supporting selective transmission of a first subset of the ions within the first analyzer region; and, d) a second voltage source for providing at least a temporally varying voltage to at least one of the two electrodes of the second analyzer, to form an electric field therebetween, the field for in use trapping ions within the second analyzer region; wherein the second analyzer traps more ions of a first ionic species relative to ions of a second ionic species compared to a similar system having only the second analyzer. 22. An apparatus according to claim 21 wherein the second analyzer is a FAIMS analyzer capable of operating in a mode of operation for selectively trapping ions. 23. An apparatus according to claim 22 wherein the two electrodes of the second analyzer comprise outer and inner generally cylindrical coaxially aligned electrode bodies defining a generally annular space therebetween, the annular space forming the second analyzer region. 24. An apparatus according to claim 23 wherein the inner generally cylindrical electrode body of the second analyzer is provided with a terminus shaped for directing the ions generally radially inwardly toward a central longitudinal axis of the inner electrode. 25. An apparatus according to claim 24 the terminus has a smoothly curved surface. 26. An apparatus according to claim 23 wherein one of the two electrodes of the first analyzer is a same electrode as one of the two electrodes of the second analyzer. 27. An apparatus according to claim 21 comprising a gas cell disposed between the first analyzer and the second analyzer, the gas cell in communication with an ion inlet for receiving ions from the first analyzer and an ion outlet for providing ions to the second analyzer, the gas cell in communication with a gas inlet and a gas outlet for providing a gas flow through the gas cell and out the gas outlet. 28. An apparatus according to claim 21 wherein the second analyzer is a mass spectrometer for selectively trapping ions
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