초록 ▼

Controlled release dosage forms for low solubility drugs are disclosed wherein an amorphous solid dispersion of the drug is coated with a non-dissolving and non-eroding coating that controls the influx of water to the core so as to cause extrusion of a portion of the core, as well as a method of tre

Controlled release dosage forms for low solubility drugs are disclosed wherein an amorphous solid dispersion of the drug is coated with a non-dissolving and non-eroding coating that controls the influx of water to the core so as to cause extrusion of a portion of the core, as well as a method of treating a disease or disorder comprising administering such dosage form to a person.

대표청구항 ▼

Controlled release dosage forms for low solubility drugs are disclosed wherein an amorphous solid dispersion of the drug is coated with a non-dissolving and non-eroding coating that controls the influx of water to the core so as to cause extrusion of a portion of the core, as well as a method of tre

Controlled release dosage forms for low solubility drugs are disclosed wherein an amorphous solid dispersion of the drug is coated with a non-dissolving and non-eroding coating that controls the influx of water to the core so as to cause extrusion of a portion of the core, as well as a method of treating a disease or disorder comprising administering such dosage form to a person. l matrix including an absorbent fibrous material comprising alginate salt, said hydrogel matrix being loaded with material comprising: a hydrocolloid moisture retaining compound selected from the materials consisting of carboxymethyl cellulose, gelatin, and mixtures thereof said materials being present in a proportion of between more than 0 wt % and about 1 wt % calculated on a dry basis' a hypertonic salt component selected from the group consisting of sea salt, sodium salts, magnesium salts, silver salts, and combinations thereof, said salt component being present in a proportion of more than 4.5 wt % and up to 50 wt % calculated on a dry basis, said salt component being compatible with the tissue being treated and acting as a disinfectant; a second disinfectant component selected from the materials consisting of organic acids, chlorinated phenolics, terpineols, biguanides, quaternary ammonium compounds, surfactants, aldehydes, halogens, peroxides and other oxygenators, aluminum zinc compounds, furan derivatives and quinoline derivatives, and mixtures thereof; and a vulnerary polysaccharide component being therapeutically acceptable with regard to wound tissue irritation level and systemic toxicity level.