Hemoactive compositions and methods for their manufacture and use
원문보기
IPC분류정보
국가/구분
United States(US) Patent
등록
국제특허분류(IPC7판)
A61K-038/17
A61K-031/74
A61K-035/14
A61K-009/00
출원번호
US-0330315
(1999-06-10)
발명자
/ 주소
Reich, Cary J.
Osawa, A. Edward
Tran, Helen
출원인 / 주소
Baxter Healthcare Corporation
대리인 / 주소
Townsend and Townsend and Crew LLP
인용정보
피인용 횟수 :
100인용 특허 :
29
초록▼
Dried hemoactive materials comprise both a cross-linked biologically compatible polymer and a non-cross-linked biologically compatible polymer. The cross-linked polymer is selected to form a hydrogel when exposed to blood. The non-cross-linked polymer is chosen to solubilize relatively rapidly when
Dried hemoactive materials comprise both a cross-linked biologically compatible polymer and a non-cross-linked biologically compatible polymer. The cross-linked polymer is selected to form a hydrogel when exposed to blood. The non-cross-linked polymer is chosen to solubilize relatively rapidly when exposed to blood. The non-cross-linked polymer serves as a binder for holding the materials in desired geometries, such as sheets, pellets, plugs, or the like. Usually, the cross-linked polymer will be present in a particulate or fragmented form. The materials are particularly suitable for hemostasis and drug delivery.
대표청구항▼
Dried hemoactive materials comprise both a cross-linked biologically compatible polymer and a non-cross-linked biologically compatible polymer. The cross-linked polymer is selected to form a hydrogel when exposed to blood. The non-cross-linked polymer is chosen to solubilize relatively rapidly when
Dried hemoactive materials comprise both a cross-linked biologically compatible polymer and a non-cross-linked biologically compatible polymer. The cross-linked polymer is selected to form a hydrogel when exposed to blood. The non-cross-linked polymer is chosen to solubilize relatively rapidly when exposed to blood. The non-cross-linked polymer serves as a binder for holding the materials in desired geometries, such as sheets, pellets, plugs, or the like. Usually, the cross-linked polymer will be present in a particulate or fragmented form. The materials are particularly suitable for hemostasis and drug delivery. rom about 0.005 to about 0.5 grams of copper (per gram of said metal support). 2. A catalyst according to claim 1, wherein said metal support comprises at least about 50% (by weight) copper. 3. A zatalyst according to claim 2, wherein said copper-containing coating comprises from about 0.02 to about 0.3 grams of copper (per gram of said metal support). 4. A catalyst as set forth in claim 2, wherein said copper-containing coating comprises from about 0.08 to about 0.15 grams of copper (per gram of said metal sponge support). 5. A catalyst according to claim 1, wherein said metal support comprises from about 60 to about 80% (by weight) copper. 6. A catalyst as set forth in claim 1, wherein said non-copper metal comprises metal having a reduction potential which is less than about +343 mVolts vs. NHE. 7. A catalyst as set forth in claim 1, wherein said metal support comprises at least about 10% (by weight) of a metal selected from the group consisting of nickel, zinc, tin, cobalt, iron and combinations thereof. 8. A catalyst as set forth in claim 1, wherein said metal sponge support comprises at least about 10% (by weight) nickel. 9. A catalyst as set forth in claim 1, wherein said metal sponge support comprises at least about 10% (by weight) zinc. 10. A catalyst as set forth in claim 9, wherein said metal sponge support comprises from about 10 to about 35% by weight) zinc. 11. A catalyst as set forth in claim 1, wherein said metal sponge support comprises at least about 10% (by weight) tin. 12. A catalyst as set forth in claim 1, wherein sai& metal sponge support comprises at least about 10% (by weight) cobalt. 13. A catalyst as set forth in claim 1, wherein said metal sponge support comprises at least about 10% (by weight) iron. 14. A catalyst as set forth in claim 1, wherein said catalyst further comprises from about 0.002 to about 5% (by weight) of a metal selected from the group consisting of chromium, titanium, niobium, tantalum, zirconium, vanadium, molybdenum, manganese, tungsten, bismuth, tin, antimony, lead, germanium and combinations thereof. 15. A catalyst as set forth in claim 14, wherein said catalyst further comprises from about 0.005 to about 2% (by weight) of a metal selected from the group consisting of chromium, vanadium, molybdenum and combinations thereof. 16. A catalyst comprising: a metal support comprising (a) at least about 10% (by weight) copper, and (b) at least about 65% (by weight) non-copper metal; and a copper-containing coating comprising from about 0.005 to about 0.5 grams of copper (per gram of said metal support). 17. A catalyst as set forth in claim 16, wherein said metal support comprises at least about 80% (by weight) non-copper metal. 18. A catalyst as set forth in claim 16, wherein said copper-containing coating comprises from about 0.02 to about 0.3 grams of copper (per gram of said metal support). 19. A catalyst as set forth in claim 16, wherein said copper-containing coating comprises from about 0.08 to about 0.15 grams of copper (per gram of said metal support). 20. A catalyst as set forth in claim 16, wherein said metal support comprises at least about 65% (by weight) of a non-copper metal selected from the group consisting of nickel, zinc, cobalt, tin, iron and combinations thereof. 21. A catalyst as set forth in claim 16, wherein said metal support comprises a metal sponge. 22. A catalyst as set forth in claim 21, wherein said metal sponge support comprises at least about 65% (by weight) of a non-copper metal selected from the group consisting of nickel, zinc, cobalt, tin, iron and combinations thereof. 23. A catalyst as set forth in claim 21, wherein said metal sponge support comprises at least about 65% (by weight) nickel. 24. A catalyst as set forth in claim 23, wherein said metal sponge support comprises at least about 80% (by weight) nickel.
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