[특허]Systems and methods for delivering agents into targeted tissue of a living being

Systems and methods for delivering agents into targeted tissue of a living being 원문보기

IPC분류정보
국가/구분	United States(US) Patent 등록
국제특허분류(IPC7판)	A61M-031/00
출원번호	US-0368410 (1999-08-05)
발명자 / 주소	Nash, John E. Evans, Douglas G. Hoganson, David M.
출원인 / 주소	Kensey Nash Corporation
대리인 / 주소	Caesar, Rivise, Bernstein, Cohen & Pokotilow, Ltd.
인용정보	피인용 횟수 : 41 인용 특허 : 59

초록 ▼

The systems basically comprise a delivery system for accessing the targeted tissue within the living being and introduction of at least one agent at select locations in the into the myocardium and other select tissues. The delivery systems are arranged to access the tissues of the heart. One or more of the systems can be utilized during transluminal, transthoracic and direct surgical access procedures. Where appropriate, for example in the case of intraventricular access, portions of the system are steerable to properly orient the device. The instruments may pierce the heart tissue and create channels extending from the endocardium, the epicardium, or the cardiac vessels. When tissue penetration is utilized, the device may include a feature to control the depth of penetration. To minimize bleeding through the channels the device can dilate small initial punctures that later contract down after device removal. When the formation of channels is required, this can be achieved, by way of example, with a rotary-tipped device, pressurized fluid jet devices, vibratory instruments and piercing needle-like tip devices. The system may utilize some form of mechanical action or application of energy (e.g. electrical, sonic, thermal, optical, pressurized fluid, radio frequency (RF), nuclear) in the process. The mechanical action or energy application may affect the surroundings tissues at a distance from the device. The agent delivered to the tissue may include one or more of pharmaceuticals, biologically active agents, radiopaque materials, etc.

대표청구항 ▼

1. A method of vascularizing cardiac tissue of a living being using an instrument extended through a portion of the living being to an entry situs located within a vessel, duct or lumen at or adjacent the cardiac tissue, said method comprising the steps of: (a) providing a flowable agent comprising a fluid and plurality of small particles; (b) introducing said flowable agent through said instrument at said entry situs; and (c) imparting a particle-moving force through said instrument to said flowable agent, said particle-moving force being generated external to the living being to cause said flowable agent to form at least one stream of said fluid and said particles for passing directly through the tissue of said vessel, duct or lumen and contiguous tissue to target cardiac tissue located remotely from said entry situs, whereupon at least said particles of said stream pass through said tissue of said vessel, duct or lumen and contiguous tissue under the impetus of said particle-moving force without any mechanical means carrying said particles through said contiguous tissue, to directly enter said target cardiac tissue. 2. The method of claim 1 wherein at least some portion of at least some of said particles is formed of a material to cause the formation of lumens in communication with the being's arterial system. 3. The method of claim 1 wherein the cardiac tissue comprises the myocardium and wherein said method additionally comprises the step of applying energy to said flowable agent, and directing said flowable agent into the myocardium to treat the cardiac tissue. 4. The method of claim 3 wherein the presence of said flowable agent in the myocardium produces channels therein. 5. The method of claim 1 additionally comprising the step of monitoring the cardiac cycle of the being and coordinating the introduction of said flowable agent with the cardiac cycle.

이 특허에 인용된 특허 (59)

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Systems and methods for delivering agents into targeted tissue of a living being 원문보기

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