Method and apparatus for dispensing low nanoliter volumes of liquid while minimizing waste
IPC분류정보
국가/구분
United States(US) Patent
등록
국제특허분류(IPC7판)
G01N-001/10
B01L-003/02
출원번호
US-0562652
(2000-05-02)
발명자
/ 주소
Downs, Robert C.
Weselak, Mark R.
출원인 / 주소
IRM LLC
대리인 / 주소
Smith, Timothy L.Wang, HughBrook, Mitchell P.
인용정보
피인용 횟수 :
8인용 특허 :
38
초록▼
There is provided a method and apparatus for aspirating a volume of liquid into a syringe from a sample of the liquid. A substantial portion of the liquid in the syringe is subsequently dispensed from the syringe and returned to the sample. Accordingly, a small portion of the aspirated liquid is ret
There is provided a method and apparatus for aspirating a volume of liquid into a syringe from a sample of the liquid. A substantial portion of the liquid in the syringe is subsequently dispensed from the syringe and returned to the sample. Accordingly, a small portion of the aspirated liquid is retained in the syringe. One or more nanoliter volumes of the liquid retained in the syringe are then dispensed from the syringe to a container for further use or analysis. It will be understood, therefore, that the volume of the originally aspirated liquid is substantially larger than the volume of liquid dispensed for further use or analysis. The invention also includes a method and apparatus for aspirating and dispensing a plurality of liquids by using a plurality of syringes, and also can be used to dispense liquids onto microplates.
대표청구항▼
There is provided a method and apparatus for aspirating a volume of liquid into a syringe from a sample of the liquid. A substantial portion of the liquid in the syringe is subsequently dispensed from the syringe and returned to the sample. Accordingly, a small portion of the aspirated liquid is ret
There is provided a method and apparatus for aspirating a volume of liquid into a syringe from a sample of the liquid. A substantial portion of the liquid in the syringe is subsequently dispensed from the syringe and returned to the sample. Accordingly, a small portion of the aspirated liquid is retained in the syringe. One or more nanoliter volumes of the liquid retained in the syringe are then dispensed from the syringe to a container for further use or analysis. It will be understood, therefore, that the volume of the originally aspirated liquid is substantially larger than the volume of liquid dispensed for further use or analysis. The invention also includes a method and apparatus for aspirating and dispensing a plurality of liquids by using a plurality of syringes, and also can be used to dispense liquids onto microplates. rradiation Crosslinking", (1993), App. Biochem. Biotech., 41: 87-97. Ikada, "Surface Modification of Polymers for Medical Applications", (1994), Biomaterials, 15/10: 725-736. Lamture et al., "Direct Detectoin of Nucleic Acid Hybridization on the Surface of a Charge Coupled Device", (1994) Nucleic Acids Res., 22/11: 2121-2125. Lee et al., "Automated System for Fractionation of Blood Samples" (1978), Clin. Chem., 24/8: 1361-1365. Linliu et al., "Development of a Centrifuge Ball Viscometer for Polymer Melts", (1994), Rev. Sci. Instrum., 65/12: 3823-3828. Nakagawa et al., "A Micro Chemical Analyzing System Integrated on a Silicon Wafer", Proc. IEEE Workshop of Micro Electro Mechanical Systems, p. 89. Poole et al., "Instrumental Thin-Layer Chromatography", (Jan. 1994), Anal. Chem., 66/1: 27A-37A. Reijenga et al., "Effect of Electroosmosis on Detection in Isotachophoresis", (1983), J. Chromatography, 260: 241-254. Renoe et al., "A Versatile Minidisc Module for a Centrifugal Analyzer" (1974), Clain. Chem., 20/8:955-960. Rosenzweig et al., "Laser-Based Particle-Counting Microimmunoassay for the Analysis of Single Human Erythorcytes" (1994), Anal. Chem., 66: 1771-1776. Schembri et al., "Portable Simultan
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이 특허에 인용된 특허 (38)
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