초록 ▼

The invention provides a material for use in a wound dressing or wound implant, the material comprising a plurality of beads, wherein each bead comprises a porous core of a first bioabsorbable material and a substantially non-porous layer of a second bioabsorbable material around the core. The porou

The invention provides a material for use in a wound dressing or wound implant, the material comprising a plurality of beads, wherein each bead comprises a porous core of a first bioabsorbable material and a substantially non-porous layer of a second bioabsorbable material around the core. The porous core is preferably a sponge formed by freeze-drying a liquid suspension of the first bioabsorbable material. The preferred diameter of the beads is 0.1-4.0 mm, and the beads are preferably dispersed in a liquid or solid matrix. The invention also provides a method of making beads for use in the materials of the invention.

대표청구항 ▼

1. A material for use in a wound dressing or a wound implant, the material comprising a plurality of beads, wherein each bead comprises a porous core of a first bioabsorbable material and a substantially non-porous layer of a second bioabsorbable material around said core. 2. A material according to

1. A material for use in a wound dressing or a wound implant, the material comprising a plurality of beads, wherein each bead comprises a porous core of a first bioabsorbable material and a substantially non-porous layer of a second bioabsorbable material around said core. 2. A material according to claim 1, wherein the first and/or the second bioabsorbable material consists essentially of collagen. 3. A material according to claim 1 or 2, wherein said beads are substantially spherical. 4. A material according to claim 1 or 2, wherein the mean outside diameter of said beads is in the range 0.1 to 4.0 mm. 5. A material according claim 4, wherein the mean thickness of said layer of said second bioabsorbable material is in the range 0.01 mm to 1.0 mm. 6. A material according to claim 5, wherein the mean pore diameter in said porous core is in the range 50 μm to 350 μm. 7. A material according to claim 6, further comprising an active therapeutic agent in said porous core and/or in said substantially non-porous layer. 8. A material according to claim 7, wherein said material is a fluid or paste comprising said beads dispersed in a liquid or gel carrier. 9. A method of making bioabsorbable beads for use in wound dressings or implants, the method comprising: providing a dispersion of a first bioabsorbable material in a liquid solvent; generating droplets of said dispersion; freezing said droplets to form frozen droplets; freeze-drying or solvent-drying the frozen droplets to form discrete porous cores of said first bioabsorbable material; and coating said porous cores with a substantially non-porous layer of a second bioabsorbable material. 10. A method according to claim 9, wherein said solvent is an aqueous solvent.