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Gene discovery using microarrays 원문보기

IPC분류정보
국가/구분 United States(US) Patent 등록
국제특허분류(IPC7판)
  • C12Q-001/68
  • C07H-021/02
  • C07H-021/04
  • G06F-019/00
출원번호 US-0781814 (2001-02-12)
발명자 / 주소
  • Shoemaker, Daniel D.
  • Scherer, Stewart
  • Altschuler, Steven J.
  • Wu, Lani F.
  • Armour, Christopher D.
출원인 / 주소
  • Rosetta Inpharmatics LLC
대리인 / 주소
    Pennie & Edmonds LLP
인용정보 피인용 횟수 : 18  인용 특허 : 37

초록

The invention relates to methods and systems (e.g., computer systems and computer program products) for identifying and characterizing genes using microarrays. In particular, the invention provides for improved, robust methods for detecting genes through the use of microarrays to analyze the express

대표청구항

The invention relates to methods and systems (e.g., computer systems and computer program products) for identifying and characterizing genes using microarrays. In particular, the invention provides for improved, robust methods for detecting genes through the use of microarrays to analyze the express

이 특허에 인용된 특허 (37)

  1. Israel David I., Analysis of gene expression, methods and reagents therefor.
  2. Beattie Kenneth Loren, Arbitrary sequence oligonucleotide fingerprinting.
  3. Fodor Stephen P. A. (Palo Alto CA) Pirrung Michael C. (Durham NC) Read J. Leighton (Palo Alto CA) Stryer Lubert (Stanford CA), Array of oligonucleotides on a solid substrate.
  4. Fodor Stephen P.A. ; Stryer Lubert ; Read J. Leighton ; Pirrung Michael C., Arrays of materials attached to a substrate.
  5. Cronin Maureen T. ; Miyada Charles Garrett ; Hubbell Earl A. ; Chee Mark ; Fodor Stephen P. A. ; Huang Xiaohua C. ; Lipshutz Robert J. ; Lobban Peter E. ; Morris Macdonald S. ; Sheldon Edward L., Arrays of nucleic acid probes and methods of using the same for detecting cystic fibrosis.
  6. Chee Mark ; Cronin Maureen T. ; Fodor Stephen P. A. ; Huang Xiaohua X. ; Hubbell Earl A. ; Lipshutz Robert J. ; Lobban Peter E. ; Morris MacDonald S. ; Sheldon Edward L., Arrays of nucleic acid probes on biological chips.
  7. Drmanac Radoje T.,YUX ; Crkvenjakov Radomir B.,YUX, Computer-aided analysis system for sequencing by hybridization.
  8. Lockhart David J. ; Brown Eugene L. ; Wong Gordon G. ; Chee Mark S. ; Gingeras Thomas R., Expression monitoring by hybridization to high density oligonucleotide arrays.
  9. Deiss Louis Paul ; Yehiely Fruma ; Efimova Elena ; Vasquez-Iaslop Nora Cecilia ; Einat Paz,ILX, Gene identification method.
  10. Cronin Maureen T. ; Miyada Charles Garrett ; Trulson Mark ; Gingeras Thomas R. ; McGall Glenn ; Robinson Claire ; Oval Michelle, Hybridization assays on oligonucleotide arrays.
  11. Trulson Mark (Santa Clara CA) Stern David (Mountain View CA) Fiekowsky Peter (Los Altos CA) Rava Richard (Palo Alto CA) Walton Ian (Menlo Park CA) Fodor Stephen P. A. (Palo Alto CA), Method and apparatus for imaging a sample on a device.
  12. Friend Stephen H. ; Stoughton Roland, Method for determining the presence of a number of primary targets of a drug.
  13. Gray Donald M. ; Clark Chris L., Method for selectively ranking sequences for antisense targeting.
  14. Wallace R. Bruce, Method of detecting and discriminating between nucleic acid sequences.
  15. Marton Matthew ; Stoughton Roland, Methods for determining therapeutic index from gene expression profiles.
  16. Ashby Matthew (San Aselmo CA) Rine Jasper (Moraga CA), Methods for drug screening.
  17. Stoughton Roland ; Friend Stephen H., Methods for identifying pathways of drug action.
  18. Coull James M. ; Hyldig-Nielsen Jens J. ; Godtfredsen Sven E.,DKX ; Fiandaca Mark J. ; Stefano Kyriaki, Methods for suppressing the binding of detectable probes to non-target sequences in hybridization assays.
  19. Stoughton Roland ; Karp Richard M., Methods for testing biological network models.
  20. Friend Stephen H. ; Stoughton Roland, Methods for using co-regulated genesets to enhance detection and classification of gene expression patterns.
  21. Khrapko Konstantin R. (Moscow RUX) Khorlin Alexandr A. (Moscow RUX) Ivanov Igor B. (Moskovskaya RUX) Ershov Gennady M. (Moscow RUX) Lysov Jury P. (Moscow RUX) Florentiev Vladimir L. (Moscow RUX) Mirz, Methods of DNA sequencing by hybridization based on optimizing concentration of matrix-bound oligonucleotide and device.
  22. Friend Stephen H. ; Stoughton Roland, Methods of determining protein activity levels using gene expression profiles.
  23. Friend Stephen H. ; Stoughton Roland, Methods of monitoring disease states and therapies using gene expression profiles.
  24. Cantor Charles R. (Boston MA), Methods of preparing probe array by hybridation.
  25. Beattie Kenneth L., Microfabricated, flowthrough porous apparatus for discrete detection of binding reactions.
  26. Mitsuhashi Masato (Irvine CA) Cooper Allan J. (Bellvue WA) Waterman Michael S. (Culver City CA) Pevzner Pavel A. (State College PA), Oligoprobe designstation: a computerized method for designing optimal DNA probes.
  27. Wong Wing H., Parallel polynucleotide sequencing method using tagged primers.
  28. Cook Phillip D. (Carlsbad CA) Kiely John (San Diego CA) Sprankle Kelly (Vista CA), Peptide nucleic acid combinatorial libraries and improved methods of synthesis.
  29. Dehlinger Peter J., Position-addressable polynucleotide arrays.
  30. Cantor Charles R. ; Przetakiewicz Marek ; Sano Takeshi ; Smith Cassandra L., Positional sequencing by hybridization.
  31. Van Gelder Russell N. (2200 Divot Dr. Crystal Lake MD 63131) Von Zastrow Mark E. (11570 Buena Vista Dr. Los Altos CA 94022) Barchas Jack D. (1900 Rittenhouse Sq. #18A Philadelphia PA 19103) Eberwine , Process for amplifying a target polynucleotide sequence using a single primer-promoter complex.
  32. Van Gelder Russell N. ; Von Zastrow Mark E. ; Barchas Jack D. ; Eberwine James H., Processes for genetic manipulations using promoters.
  33. Van Gelder Russell N. ; Von Zastrow Mark E. ; Barchas Jack D. ; Eberwine James H., Processes for genetic manipulations using promoters.
  34. Linsley Peter S. ; Schelter Janell M., RNA amplification method.
  35. Blanchard Alan P., Solvent for oligonucleotide synthesis and methods of use.
  36. Lockhart David J. (Santa Clara CA) Vetter Dirk (Freiburg DEX) Diggelmann Martin (Niederdorf CHX), Surface-bound, unimolecular, double-stranded DNA.
  37. Fodor Stephen P. A. (Palo Alto CA) Pirrung Michael C. (Durham NC) Read J. Leighton (Palo Alto CA) Stryer Lubert (Stanford CA), Synthesis and screening of immobilized oligonucleotide arrays.

이 특허를 인용한 특허 (18)

  1. Shoemaker, Daniel D.; Scherer, Stewart; Friend, Stephen H., Compositions and methods for exon profiling.
  2. Kumar, Gyanendra; Abarzua, Patricio; Egholm, Michael, Detection method using dissociated rolling circle amplification.
  3. Bingham,Jonathan; Srinivasan,Subha, Method and system for identifying splice variants of a gene.
  4. Korfhage, Christian; Löffert, Dirk, Method for activating a nucleic acid for a polymerase reaction.
  5. Corson, John Frederick; Ghosh, Jayati; Shchegrova, Svetlana, Methods and systems for detrending signal intensity data from chemical arrays.
  6. Corson,John Frederick; Ghosh,Jayati; Shchegrova,Svetlana, Methods and systems for detrending signal intensity data from chemical arrays.
  7. Srinivasan, Subha; Bingham, Jonathan, Methods and systems for polynucleotide detection.
  8. Weng,Lee, Methods for analysis of measurement errors in measured signals.
  9. Weng, Lee, Methods of analyzing multi-channel profiles.
  10. Marton, Matthew; Meyer, Michael; Jones, Allan, Methods to assess quality of microarrays.
  11. Tzean, Shean-Shong; Shu, Po-Yao; Tzean, Yuh, Microchip for identifying Phellinus species and the method thereof.
  12. Lasken, Roger S.; Egholm, Michael; Alsmadi, Osama A., Nucleic acid amplification.
  13. Fan,Jian Bing; Fu,Xiang Dong, Nucleic acid detection methods using universal priming.
  14. Schweighoffer, Fabien; Bracco, Laurent; Tocque, Bruno, Qualitative differential screening.
  15. Korfhage, Christian; Peist, Ralf; Löffert, Dirk, Reverse transcription and amplification of RNA with simultaneous degradation of DNA.
  16. Lizardi, Paul M., Rolling circle replication reporter systems.
  17. Zhang, Zheng; Utiramerur, Sowmi; Hyland, Fiona, Systems and methods for sequence data alignment quality assessment.
  18. Abarzúa, Patricio; Smelkova, Natalia; Sparkowski, Jason, Universal reagents for rolling circle amplification and methods of use.
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