A food additive useful for lowering serum cholesterol in humans contains a sterol or stanol ester of a fatty acid or a dicarboxylic acid ester of a sterol or stanol made by reacting a sterol, stanol and a carboxylic acid in the presence of an effective amount of a catalyst selected from the group co
A food additive useful for lowering serum cholesterol in humans contains a sterol or stanol ester of a fatty acid or a dicarboxylic acid ester of a sterol or stanol made by reacting a sterol, stanol and a carboxylic acid in the presence of an effective amount of a catalyst selected from the group consisting of calcium oxide, calcium hydroxide, a calcium salt of a carboxylic acid, magnesium hydroxide and combinations thereof described herein below.
대표청구항▼
1. A process for preparing an ester, said process comprising reacting at least one first reactant selected from the group consisting of sterols, stanols, and combinations thereof with at least one second reactant selected from the group consisting of carboxylic acids and carboxylic acid esters in th
1. A process for preparing an ester, said process comprising reacting at least one first reactant selected from the group consisting of sterols, stanols, and combinations thereof with at least one second reactant selected from the group consisting of carboxylic acids and carboxylic acid esters in the presence of a catalytically effective amount of a catalyst selected from the group consisting of calcium oxide, calcium hydroxide, a calcium salt of a carboxylic acid, magnesium hydroxide and combinations thereof. 2. The process according to claim 1, wherein the at least one first reactant comprises β-sitosterol. 3. The process according to claim 1, wherein the at least one first reactant comprises β-sitostanol. 4. The process according to claim 1, wherein the catalyst comprises calcium hydroxide, calcium oxide or a calcium salt of a carboxylic acid. 5. The process according to claim 1 , wherein the at least one second reactant comprises a carboxylic acid having from about 2 to 22 carbon atoms. 6. The process according to claim 1, wherein the catalyst comprises calcium oxide. 7. The process according to claim 1, wherein the at least one second reactant comprises a mixture of long chain carboxylic acids derived from an oil selected from the group consisting of sunflower oil, palm kernel oil, coconut oil, rape seed oil, tallow oil, corn oil, canola oil, linseed oil, palm oil, olive oil, sesame oil, and safflower oil. 8. The process according to claim 1 , wherein a reaction mixture comprising the at least one first reactant, the at least one second reactant and the catalytically effective amount of the catalyst is reacted in a reaction zone; and passing at least a portion of the reaction mixture through an evaporation zone to remove the water of reaction from the reaction mixture. 9. The process according to claim 8, further comprising returning the portion of the reaction mixture to the reaction zone. 10. The process according to claim 8, wherein the catalyst comprises calcium oxide. 11. The process according to claim 1 , wherein the at least one second reactant comprises a carboxylic acid ester. 12. The process according to claim 11, wherein the at least one first reactant comprises β-sitosterol. 13. The process according to claim 11, wherein the at least one first reactant comprises β-sitostanol. 14. The process according to claim 11, wherein the catalyst comprises calcium hydroxide, calcium oxide or a calcium salt of a carboxylic acid. 15. The process according to claim 14, wherein the at least one second reactant comprises a carboxylic acid ester having from about 2 to 22 carbon atoms. 16. The process according to claim 14, wherein the at least one second reactant comprises a methyl ester of a C6-22fatty acid or a triglyceride. 17. A process which comprises reacting β-sitostanol with a carboxylic acid ester in the presence of an effective amount of calcium oxide. 18. A process for making a food additive composition, said process comprising: (a) providing an edible solubilizing agent; (b) providing an effective amount of a suitable dispersant; (c) providing an ester prepared by reacting at least one first reactant selected from the group consisting of sterols, stanols, and combinations thereof with at least one second reactant selected from the group consisting of carboxylic acids and carboxylic acid esters in the presence of a catalytically effective amount of a catalyst selected from the group consisting of calcium oxide, calcium hydroxide, a calcium salt of a carboxylic acid, magnesium hydroxide and combinations thereof; and (d) combining the edible solubilizing agent, the suitable dispersant and the ester. 19. The process according to claim 18, further comprising providing an antioxidant and combining the antioxidant with the edible solubilizing agent, the suitable dispersant and the ester.
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