초록 ▼

The present invention relates to AUR1 and/or AUR2 polypeptides, nucleic acids encoding such polypeptides, cells, tissues and animals containing such nucleic acids, antibodies to such polypeptides, assays utilizing such polypeptides, and methods relating to all of the foregoing. Methods for treatment

The present invention relates to AUR1 and/or AUR2 polypeptides, nucleic acids encoding such polypeptides, cells, tissues and animals containing such nucleic acids, antibodies to such polypeptides, assays utilizing such polypeptides, and methods relating to all of the foregoing. Methods for treatment, diagnosis, and screening are provided for AUR1 and/or AUR2 related diseases or conditions characterized by an abnormal interaction between a AUR1 and/or AUR2 polypeptide and a AUR1 and/or AUR2 binding partner.

대표청구항 ▼

The present invention relates to AUR1 and/or AUR2 polypeptides, nucleic acids encoding such polypeptides, cells, tissues and animals containing such nucleic acids, antibodies to such polypeptides, assays utilizing such polypeptides, and methods relating to all of the foregoing. Methods for treatment

The present invention relates to AUR1 and/or AUR2 polypeptides, nucleic acids encoding such polypeptides, cells, tissues and animals containing such nucleic acids, antibodies to such polypeptides, assays utilizing such polypeptides, and methods relating to all of the foregoing. Methods for treatment, diagnosis, and screening are provided for AUR1 and/or AUR2 related diseases or conditions characterized by an abnormal interaction between a AUR1 and/or AUR2 polypeptide and a AUR1 and/or AUR2 binding partner. 44. Theisen et al., "Polymorphism in ospC Gene of Borrelia burgdorferi and Immunoreactivity of OspC Protein: Implications for Taxonomy and for Use of OspC Protein as a Diagnostic Antigen", Journal of Clinical Microbiology, vol. 31, No. 10 (Oct. 1993) pp. 2570-2576. Wilske et al., "Phenotypic Analysis of Outer Surface Protein C (OspC) of Borrelia burgdorferi Sensu Lato by Monoclonal Antibodies: Relationship to Genospecies and OspA Serotype", Journal of Clinical Microbiology, vol. 33, No. 1 (Jan. 1995) pp. 103-109. Wilske et al., "Detection of IgM- and IgG Antibodies to Borrelia burgdorferi Using Different Strains as Antigen", Lyme Borreliosis II, Zbl. Bakt. Suppl. 18 (1989) pp. 299-309. Wilske et al., "Immunological and Molecular Polymorphisms of OspC, an Immunodominant Major Outer Surface Protein of Borrelia burgdorferi", Infection and Immunity, vol. 51, No. 5 (May 1993) pp. 2182-2191. Yu et al., "Multi-well ELISA based on independent peptide antigens for antibody capture Application to Lyme disease serodiagnosis", Journal of Immunological Methods, vol. 198 (1996) pp. 25-33. Gerber et al., "Recombinant Outer Surface Protein C ELISA for the Diagnosis of Early Lyme Disease", The Journal of Infectious Diseases, vol. 171 (Mar. 1995) pp. 724-727. Fung et al., "Humoral Immune Response to Outer Surface Protein C of Borrelia burgdorferi in Lyme Disease: Role of the Immunoglobulin M Response in the Serodiagnosis of Early Infection", Infection and Immunity, vol. 62, No. 8 (Aug. 1994) pp. 3213-3221. Padula et al., "Use of Recombinant OspC from Borrelia burgdorferi for Serodiagnosis of Early Lyme Disease", Journal of Clinical Microbiology, vol. 32, No. 7 (Jul. 1994) pp. 1733-1738. Padula et al., "Molecular Characterization and Expression of p23 (OspC) from a North American Strain of Borrelia burgdorferi", Infection and Immunity, vol. 61, No. 12 (Dec. 1993) pp. 5097-5105. Wilske et al., "Recombinant immunoblot in the serodiagnosis of Lyme borreliosis", Medical Microbiology and Immunology, vol. 182 (1993) pp. 255-270. Lebech et al., "Detection of Borrelia burgdorferi DNA in Urine Samples and Cerebrospinal Fluid Samples from Patients with Early and Late Lyme Neuroborreliosis by Polymerase Chain Reaction" Journal of Clinical Microbiology, vol. 30, No. 7 (Jul. 1992) pp. 1646-1653. Hansen et al., "Improved Immunoglobulin M Serodiagnosis in Lyme Borreliosis by Using a u-Capture Enzyme-Linked Immunosorbent Assay with Biotinylated Borrelia burgdorferi Flagella", Journal of Clinical Microbiology, vol. 29, No. 1 (Jan. 1991) pp. 166-173. Hansen et al., "Measurement of Antibodies to the Borrelia burgdorferi Flagellum Improves Serodiagnosis in Lyme Disease", Journal of Clinical Microbiology, vol. 26, No. 2 (Feb. 1988) pp. 338-346. Dressler et al., "Antibody Responses to the Three Genomic Groups of Borrelia burgdorferi in European Lyme Borrealiosis", The Journal of Infectious Diseases, vol. 169 (Feb. 1994) pp. 318-318. The QIA expressionist 2nd Edition, KEBO Lab/QIAGEN, Inc. (1992) pp. 42-43.