초록 ▼

A process for the in-situ preparation of a composite comprising a cationic clay and binder/matrix material from sources comprising an aluminum containing source, a silicon containing source and a di-valent metal containing source comprising the steps of: a. preparing a precursor mixture by mixing

A process for the in-situ preparation of a composite comprising a cationic clay and binder/matrix material from sources comprising an aluminum containing source, a silicon containing source and a di-valent metal containing source comprising the steps of: a. preparing a precursor mixture by mixing the aluminum containing source, the silicon containing source and the di-valent metal containing source with seeding material, b. homogenizing the precursor mixture, and c. aging the precursor mixture to obtain the composite. One or two of the aluminum containing source, silicon containing source or di-valent metal containing source is to be in excess of the amount required for stoichiometry of the three sources with respect to the formation of the cationic clay. The excess source or sources will form the binder/matrix material of the composite. The invention also includes a body comprising a composite obtained by this process having binding/matrix material present in a discontinuous phase.

대표청구항 ▼

A process for the in-situ preparation of a composite comprising a cationic clay and binder/matrix material from sources comprising an aluminum containing source, a silicon containing source and a di-valent metal containing source comprising the steps of: a. preparing a precursor mixture by mixing

A process for the in-situ preparation of a composite comprising a cationic clay and binder/matrix material from sources comprising an aluminum containing source, a silicon containing source and a di-valent metal containing source comprising the steps of: a. preparing a precursor mixture by mixing the aluminum containing source, the silicon containing source and the di-valent metal containing source with seeding material, b. homogenizing the precursor mixture, and c. aging the precursor mixture to obtain the composite. One or two of the aluminum containing source, silicon containing source or di-valent metal containing source is to be in excess of the amount required for stoichiometry of the three sources with respect to the formation of the cationic clay. The excess source or sources will form the binder/matrix material of the composite. The invention also includes a body comprising a composite obtained by this process having binding/matrix material present in a discontinuous phase. target to facilitate the formation of ligand-target binding pairs; and c) designing said modified nucleic acid ligand to said target by modifying said nucleic acid ligand by adding, deleting, or substituting nucleotide residues based on said determinations made in steps a) and b) and wherein said added or substituted nucleotide residues may be chemically modified. 16. The method of claim 15 wherein the target function altering activity is inhibition of target function. 17. The method of claim 15 wherein the target function altering activity is augmentation of target function. 18. An improved nucleic acid ligand designed according to the method of claim 17. 19. A method for designing an improved nucleic acid ligand, said nucleic acid ligand capable of binding to and altering the function of a given target, wherein said improvement is produced by modifying a nucleic acid to have enhanced target function altering activity, said method comprising: a) contacting a candidate mixture of nucleic acids with the target, wherein nucleic acids having an increased affinity to the target relative to the candidate mixture may be partitioned from the remainder of the candidate mixture; b) partitioning the increased affinity nucleic acids from the remainder of the candidate mixture; c) amplifying the increased affinity nucleic acids to yield a ligand-enriched mixture of nucleic acids; d) repeating steps a)-c) as necessary to identify a nucleic acid ligand of said target; e) determining the target function altering activity of said nucleic acid ligand of step d); f) determining the three-dimensional structure of said nucleic acid ligand; g) determining the nucleic acid residues of the nucleic acid ligand that are responsible for the target function altering activity of said nucleic acid ligand, wherein said determining is selected from the group consisting of determining which nucleic acid residues in a nucleic acid ligand are necessary for maintaining the three-dimensional structure of the ligand, which residues interact with the target to facilitate the formation of ligand-target binding pairs, and both determining which nucleic acid residues in a nucleic acid ligand are necessary for maintaining the three-dimensional structure of the ligand and which residues interact with the target to facilitate the formation of ligand-target binding pairs; and h) designing said improved nucleic acid ligand to said target by modifying the nucleic acid ligand by adding, deleting, or substituting nucleotide residues based on said determinations made in steps f) and g), and wherein said added or substituted residues may be chemically modified. 20. The method of claim 19 wherein the target function altering activity is inhibition of target function. 21. The method of claim 19 wherein the target function altering activity is augmentation o