초록 ▼

The present invention relates to antimicrobial compositions, methods for the production of these compositions, and use of these compositions with medical devices, such as catheters, and implants. The compositions of the present invention advantageously provide varying release kinetics for the active

The present invention relates to antimicrobial compositions, methods for the production of these compositions, and use of these compositions with medical devices, such as catheters, and implants. The compositions of the present invention advantageously provide varying release kinetics for the active ions in the compositions due to the different water solubilities of the ions, allowing antimicrobial release profiles to be tailored for a given application and providing for sustained antimicrobial activity over time. More particularly, the invention relates to polymer compositions containing colloids comprised of salts of one or more oligodynamic metal, such as silver. The process of the invention includes mixing a solution of one or more oligodynamic metal salts with a polymer solution or dispersion and precipitating a colloid of the salts by addition of other salts to the solution which react with some or all of the first metal salts. The compositions can be incorporated into articles or can be employed as a coating on articles such as medical devices.

대표청구항 ▼

The present invention relates to antimicrobial compositions, methods for the production of these compositions, and use of these compositions with medical devices, such as catheters, and implants. The compositions of the present invention advantageously provide varying release kinetics for the active

The present invention relates to antimicrobial compositions, methods for the production of these compositions, and use of these compositions with medical devices, such as catheters, and implants. The compositions of the present invention advantageously provide varying release kinetics for the active ions in the compositions due to the different water solubilities of the ions, allowing antimicrobial release profiles to be tailored for a given application and providing for sustained antimicrobial activity over time. More particularly, the invention relates to polymer compositions containing colloids comprised of salts of one or more oligodynamic metal, such as silver. The process of the invention includes mixing a solution of one or more oligodynamic metal salts with a polymer solution or dispersion and precipitating a colloid of the salts by addition of other salts to the solution which react with some or all of the first metal salts. The compositions can be incorporated into articles or can be employed as a coating on articles such as medical devices. t one crosslinking agent selected from the group consisting of polyfunctional vinylaromatics, polyfunctional allyl aromatics, polyfunctional vinyl and allyl heterocycles, N,N'-C1-C6-alkylenediacrylamides and -dimethacrylamides, polyvinyl ethers and polyallyl ethers of saturated C2-C10-polyols having 2 to 4 OH groups per molecule, esters of unsaturated C3-C12-alcohols or of saturated C2-C20-polyols having 2 to 4 OH groups per molecule, divinylethyleneurea and cycloaliphatic olefins have 2 or 3 isolated C=C. double bonds. 7. A process according to claim 1, wherein the vinylaromatic polymers are crosslinked with at least one crosslinking agent selected from the group consisting of di- and trivinylbenzenes, divinylethylbenzene, divinyltoluene, divinylxylene, divinylnaphthalene, diallylbenzenes, triallybenzenes, trivinyl cyanurate, triallyl cyanurate, trivinyl isocyanurate, triallyl isocyanurate, N,N'-methylenediacrylamides and -dimethacrylamides, N,N'-ethylenediacrylamides and -dimethacrylamide, ethylene glycol divinyi ether, ethylene glycol diallyl ether, diethylene glycol divinyl ether, diethylene glycol diallyl ether, allyl methacrylate, ethylene glycol di(meth)acrylate, glycerol tri(meth)acrylate, pentaerythritol tetra(meth)acrylate, divinylethyleneurea, divinylpropyleneurea, divinyl adipate, hexa-1,5-diene, 2,5-diemethylhexa-1,5-diene, octa-1,7-diene, 1,2,4-trivinylcyclohexane. 8. A process according to claim 1, wherein the crosslinking agent is (i) a divinylbenzene or (ii) a mixture of divinylbenzene and aliphatic C6-C12-hydrocarbons containing 2 or 3 C=C. double bonds. 9. A process according to claim 5, wherein the crosslinking agents are used in amounts ranging from 2 to 20% by weight based on the total amount of the polymerizable monomers used. 10. A process according to claim 5, wherein the crosslinking agents are used in amounts ranging from 2 to 12% by weight based on the total amount of the polymerizable monomers used. 11. A process according to claim 1, wherein the vinylaromatic polymers are crosslinked using as crosslinking monomers one or more benzenes or naphthalenes substituted with at least two vinyl and/or vinylidene groups. 12. A process according to claim 1, wherein the vinylaromatic polymers are obtained by polymerizing at least one of styrene, vinyltoluene, ethylstyrene, alpha-methylstyrene, chlorostyrene, o-chloromethylstyrene, m-chloromethylstyrene, p-chloromethylstyrene, vinylnaphthalene, and vinylpyridine and one or more crosslinking monomers containing more than one copolymerizable double bond per molecule and, optionally, one or more nonaromatic monomers containing at least one copolymerizable double bond per molecule.