초록 ▼

The invention concerns a device for directly delivering an active substance within all or part of a human or animal tissue cell, characterized in that it is in the form of a hollow tube (1), whereof the walls in contact with said tissue are provided with perforations (5) and whereof the distal end (

The invention concerns a device for directly delivering an active substance within all or part of a human or animal tissue cell, characterized in that it is in the form of a hollow tube (1), whereof the walls in contact with said tissue are provided with perforations (5) and whereof the distal end (2) is sealed, while the proximal end (3) is shaped so as to receive removable closing means, said tube being capable of bearing a pressure of at least 50 bars.

대표청구항 ▼

1. A device for directly delivering an active substance from an exterior source to within human or animal cell tissue, the device comprising a hollow tube substantially circular in cross-section having a proximal end, a distal end, an interior surface defining an inside diameter and a smooth exterio

1. A device for directly delivering an active substance from an exterior source to within human or animal cell tissue, the device comprising a hollow tube substantially circular in cross-section having a proximal end, a distal end, an interior surface defining an inside diameter and a smooth exterior surface made of a contiguous material from the proximal end to the distal end, defining an outside diameter; (a) said exterior surface defining an outside diameter between 100 and 250 micrometers; (b) said interior surface defining an inside diameter between 50 and 150 micrometers; (c) said exterior surface and said interior surface being in fluid communication via a plurality of perforations having diameters between 30 and 70 micrometers; (d) said distal tube end being closed; and (e) said proximal tube end communicating with the exterior source of active substance, wherein said hollow tube is capable of withstanding high pressure delivery of at least 50 bar. 2. The device of claim 1 wherein said proximal tube end communicates with said exterior source of active substance via a removable closure. 3. The device of claim 2 wherein said removable closure comprises a tapping for a threaded seal. 4. The device of claim 1 further comprising a conical seal fixed to said proximal end. 5. The device of claim 1 wherein said exterior source of active substance is at 50 to 10,000 bar. 6. The device of claim 1 wherein said device is made from a material chosen from stainless steel, titanium and polytetrafluoroethylene. 7. The device of claim 1 wherein said perforations are formed in a spiral with a pitch of between 0.5 and 2 centimeters. 8. The device of claim 1, wherein at least some of the exterior surface of the device contacts the tissue. 9. The device of claim 1, wherein the inside diameter of the tube is uniform. 10. A method for delivering an active substance directly within a tissue comprising: (a) inserting a device according to claim 1 into or adjacent said tissue; and (b) applying said active substance to said tissue by forcing said active substance under pressure through said device and into said tissue. 11. A method according to claim 10 wherein said pressure is 50 to 10,000 bars. 12. A method according to claim 10 wherein said active substance is one or more members chosen from the group consisting of hydrogen peroxide vapor, water vapor, an antibiotic, a chemotherapeutic agent, an anti-inflammatory agent, a radioactive therapeutic agent and a metallic particle. 13. A method according to claim 10 wherein said tissue is liver or bone.