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Systems for delivering cosmetic and therapeutic actives to the oral cavity employ a strip comprising a first layer of material, a second layer comprising polybutene with a molecular weight of about 300 to about 3000, and a cosmetic or therapeutic active included within the second layer. Therapeutic

Systems for delivering cosmetic and therapeutic actives to the oral cavity employ a strip comprising a first layer of material, a second layer comprising polybutene with a molecular weight of about 300 to about 3000, and a cosmetic or therapeutic active included within the second layer. Therapeutic and cosmetic actives in compositions comprising polybutene inhibit or prevent gingivitis, caries, staining, fungi, bacteria and plaque build-up in the oral cavity by means of the delivery system.

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Systems for delivering cosmetic and therapeutic actives to the oral cavity employ a strip comprising a first layer of material, a second layer comprising polybutene with a molecular weight of about 300 to about 3000, and a cosmetic or therapeutic active included within the second layer. Therapeutic

Systems for delivering cosmetic and therapeutic actives to the oral cavity employ a strip comprising a first layer of material, a second layer comprising polybutene with a molecular weight of about 300 to about 3000, and a cosmetic or therapeutic active included within the second layer. Therapeutic and cosmetic actives in compositions comprising polybutene inhibit or prevent gingivitis, caries, staining, fungi, bacteria and plaque build-up in the oral cavity by means of the delivery system. Active Human Relaxin, 1983, Nature 301: 628-631. Iigo et al., Synergistic Antitumor Effects of Carboplatin and Interferons on Hepatic Metastases of Colon Carcinoma 26 and M5076 Reticulum Cell Sarcoma, 1993, Jpn. J. Cancer Res., 84:794-799. Jordan et al., A march of genetic maps, 1996, Nature 380:111-112. Kopp et al., Immunomodulatory Effects of Interferon-γ in Patients with Metastatic Malignant Melanoma, 1993, J Immunotherapy 13:181-190. Kozal et al., Extensive polymorphisms observed in HIV-1 clade B protease gene using high-density oligonucleotide arrays, 1996, Nature Medicine 2:753-759. Kramer et al., Increase in Cyclic AMP Levels by Relaxin in Newborn Rhesus Monkey Uterus Cell Culture, 1990, In Vitro Cell. Dev. Biol. 26:647-656. Li et al., Direct electrophoretic detection of the allelic state of single DNA molecules in human sperm by using the polymerase chain reaction, 1990, Proc. Natl. Acad. Sci. USA 87:4580-4584. Bolinger and Taeubel, Recombinant Interferon gamma for Treatment of Chronic Granulomatous Disease and Other Disorders, 1992, Clin. Pharm., 11:834-850. Bryant-Greenwood, D. G., At the Cutting Edge, The Human Relaxins: Consensus and Dissent, 1991, Molecular and Cellular Endocrinology 79:C125-C132. Bullesbach and Schwabe, Naturally Occuring Porcine Relaxins and Large-Scale Preparation of the B29 Hormone, 1985, Biochemistry 24:7717-7722. Bullesbach and Schwabe, Preparation and Properties of Porcine Relaxin Derivatives Shortened in the Amino Terminus of the A Chain, 1986, Biochemistry 25:5998-6004. Cha et al., Mismatch Amplification Mutation Assay (MAMA): Application to the c-H-ras Gene, 1992, PCR Methods & Applications 2:14-20. Chang et al., Multiplex Mutagenically Separated PCR: Diagnosis of β-Thalassemia and Hemoglobin Variants, 1997, Biotechniques 22:520-527. Derynck et al., Expression of the Human Interferon-γ cDNA in Yeast, 1983, Nucleic Acids Res. 11: 1819-1837. Derynck et al., Human Interferon γ is encoded by a Single Class of mRNA, 1982, Nucleic Acids Res. 10: 3605-3615. Devos et al., Molecular Cloning of Human Immune Interferon cDNA and Its Expression in Eukaryotic Cells, 1982, Nucleic Acids Res. 10:2487-2501. Devos et al., The use of random amplified polymorphic DNA markers in wheat, 1992, Theor. Appl. Genet. 84:567-572. Dietrich et al., A Genetic Map of the Mouse Suitable for Typing Intraspecific Crosses, 1992, Genetics 131:423-447. Dietrich et al., Mapping the mouse genome: Current status and future prospects, 1995, Proc. Natl. Acad. Sci. USA 92:10849-10853. Lipshutz et al., Using Oligonucleotide Probe Arrays To Access Genetic Diversity, 1995, Biotechniques 19:442-447. Nishi et al., Cloning and Expression of a Novel Variant of Human Interferon-γ cDNA, 1985, J. Biochem. 97:153-159. Park et al., Effects of Gamma Interferon on the Growth of Ascitic Sarcoma-180 and the Radioprotection of the Jejunal Mucosa in Irradiated Mice, 1994, Katollik Taehak Uihakpu Nonmunjip 47:1821-35, abstract. Pease et al., Light-generated oligonucleotide arrays for rapid DNA sequence analysis, 1994, Proc. Natl. Acad. Sci. USA 91:5022-5026. Petruska et al., Comparison between DNA melting thermodynamics and DNA polymerase fidelity, 1988, Proc. Natl. Acad. Sci. USA 85:6252-6256. Riedy et al., Excess of non-parental bands in offspring from known primate pedigrees assayed using RAPD PCR, 1992, Nucleic Acids Research 20:918. Sarkar et al., Characterization of Polymerase Chain Reaction Amplification of Specific Alleles, 1990, Analytical Biochemistry 186:64-68. Schena et al., Parallel human genome analysis: Microarray-based expression monitoring of 1000 genes, 1996, Proc. Natl. Acad. Sci. USA 93:10641-10619. Schena et al., Quantitative Monitoring of Gene Expression Patterns with a Complementary DNA Microarray, 1996, Science 270:467-470. Seelig et al., Evidence for a Polypeptide Segment at the Carboxyl Terminus of Recombinant Human γ Interferon Involved in Expression of Biological Activity, 1988, Biochemis