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Methods, compositions and drug delivery systems are provided for the transdermal administration of a pharmacologically active amine. The active agent is administered with a hydroxide-releasing agent that serves as a permeation enhancer. Exemplary hydroxide-releasing agents are inorganic hydroxides,

Methods, compositions and drug delivery systems are provided for the transdermal administration of a pharmacologically active amine. The active agent is administered with a hydroxide-releasing agent that serves as a permeation enhancer. Exemplary hydroxide-releasing agents are inorganic hydroxides, inorganic oxides, and alkali metal or alkaline earth metal salts of weak acids. Inorganic hydroxides include, for example, ammonium hydroxide, alkali metal hydroxides and alkaline earth metal hydroxides, such as sodium hydroxide, calcium hydroxide, potassium hydroxide, magnesium hydroxide, and the like.

대표청구항 ▼

Methods, compositions and drug delivery systems are provided for the transdermal administration of a pharmacologically active amine. The active agent is administered with a hydroxide-releasing agent that serves as a permeation enhancer. Exemplary hydroxide-releasing agents are inorganic hydroxides,

Methods, compositions and drug delivery systems are provided for the transdermal administration of a pharmacologically active amine. The active agent is administered with a hydroxide-releasing agent that serves as a permeation enhancer. Exemplary hydroxide-releasing agents are inorganic hydroxides, inorganic oxides, and alkali metal or alkaline earth metal salts of weak acids. Inorganic hydroxides include, for example, ammonium hydroxide, alkali metal hydroxides and alkaline earth metal hydroxides, such as sodium hydroxide, calcium hydroxide, potassium hydroxide, magnesium hydroxide, and the like. fective to repel insects when the composition is applied to skin; about 0.1 wt. % to about 20 wt. % based on the total weight of the composition of a urethane polymer, wherein the urethane polymer is selected from the group consisting of Polyurethane-1, Polyurethane-2, Polyurethane-4, Polyurethane-5, and mixtures thereof, and wherein the urethane polymer forms a film on the surface of the skin; and a cosmetically acceptable vehicle. 16. The composition of claim 15, wherein the urethane polymer is Polyurethane-1. 17. The composition of claim 15, wherein the urethane polymer is Polyurethane-2. 18. The composition of claim 15, wherein the urethane polymer is selected from the group consisting of Polyurethane-1, Polyurethane-2, Polyurethane-4, Polyurethane-5, and mixtures thereof. 19. The method of claim 8, wherein the urethane polymer is about 0.1 wt. % to about 20 wt. % based on the total weight of the composition. 20. The method of claim 8, wherein the insect repellent active is about 0.1 wt. % to about 70 wt. % based on the total weight of the composition. 21. An insect repellent composition comprising: an effective amount of an insect repellent; a film-forming urethane polymer, wherein the urethane polymer is selected from the group consisting of Polyurethane-1, Polyurethane-2, Polyurethane-4, Polyurethane-5, and mixtures thereof; and a volatile component, wherein the composition is dispensed from a spray container. 22. The composition of claim 21, wherein the composition is substantially anhydrous. 23. The composition of claim 21, wherein the spray container is selected from the group consisting of a pump spray container and an aerosol spray container. 24. The composition of claim 21, herein the volatile component is selected from the group consisting of one or more alcohols, hydrocarbons, ethers, silicones, water, and mixtures thereof. 25. The composition of claim 21, wherein the urethane polymer is Polyurethane-1. 26. The composition of claim 21, wherein the urethane polymer is Polyurethane-2. rea containing chitosan. 18. The safety razor blade of claim 17 wherein the chitosan is located either above or below a blade portion of the safety razor blade. ent TH 1704 60/186,531 Downhole Rotary Hydraulic Mar. 2, 2000 Pressure for Valve Actuation TH 1705 60/186,377 Wireless Downhole Mar. 2, 2000 Measurement and Control For Optimizing Gas Lift Well and Field Performance TH 1722 60/186,381 Controlled Downhole Mar. 2, 2000 Chemical Injection TH 1723 60/186,378 Wireless Power and Mar. 2, 2000 Communications Cross-Bar Switch The current application shares some specification and figures with the following commonly owned and concurrently filed applications in the following table, all of which are hereby incorporated by reference: [TABLE] ures with the following commonly owned and concurrently filed applications in the following table, all of which are hereby incorporated by reference: COMMONLY OWNED AND CONCURRENTLY FILED U.S. PATENT APPLICATIONS Serial T&K # Number Title Filing Date TH 1599ff 09/769,047 Choke Inductor for Wireless Jan. 24, 2001 Communications and Control TH 1600ff 09/769,048 Induction Choke for Power Jan. 24, 2001 D