IPC분류정보
| 국가/구분 |
United States(US) Patent
등록
|
| 국제특허분류(IPC7판) |
|
| 출원번호 |
US-0156300
(2002-05-28)
|
| 우선권정보 |
DK-0270/98 (1998-02-27); DK-1998 01328 (1998-10-16) |
|
발명자
/ 주소 |
- Gestrelius, Stina
- Hammarstrom, Lars
- Lyngstadaas, Petter
- Andersson, Christer
- Slaby, Ivan
- Hammargren, Tomas
|
| 출원인 / 주소 |
|
| 대리인 / 주소 |
Conlin, David G.Corless, Peter F.Rees, Dianne M.
|
| 인용정보 |
피인용 횟수 :
19 인용 특허 :
0 |
초록
Active enamel substances may be used for the preparation of a pharmaceutical or cosmetic composition for healing of a wound, improving healing of a wound, soft tissue regeneration or repair, or for preventing or treating infection or inflammation.
대표청구항
▼
1. A method of treating an infection, the method comprising administering to a mammal in need thereof a prophylactically or therapeutically effective amount of an active enamel substance. 2. The method according to claim 1, wherein the active enamel substance is selected from the group consisting of
1. A method of treating an infection, the method comprising administering to a mammal in need thereof a prophylactically or therapeutically effective amount of an active enamel substance. 2. The method according to claim 1, wherein the active enamel substance is selected from the group consisting of enamelins, amelogenins, non-amelogenins, proline-rich non-ameiogenins, amelins, tuftelins, derivatives thereof, and mixtures thereof. 3. The method according to claim 2, wherein said amelin is ameloblastin or sheathlin. 4. The method according to claim 1, wherein the active enamel substance has a molecular weight of at most about 60 kd to at most about 120 kDa, as determined by SDS Page electrophoresis. 5. The method according to claim 1, wherein the infection is a bacterial infection of the skin or of a mucosal surface. 6. The method according to claim 1, wherein the bacterial infection is an infection of the oral cavity. 7. The method according to claim 6, wherein the infection is caused by bacteria causing caries, bacteria causing periodontal disease, bacteria causing alveolitis, and bacteria causing periapical lesions. 8. The method according to claim 7, wherein the bacteria causing caries is Streptococcus mutans. 9. The method according to claim 7, wherein the bacteria causing periodontal disease is selected from the group consisting of Actinobacillus actinomycetemcomitans, Porphyromonas gingivalis, Prevotella intermedia, Peptostreptoccus micros, a Campylobacter and B. forsythus. 10. The method according to claim 9, wherein the Campylobactor is a Fusobacteria or Staphylocci. 11. The method according to claim 7, wherein the bacteria causing alveolitis is selected from the group consisting of Staphylococcus, Actinomyces, and Bacillus. 12. The method according to claim 7, wherein the bacteria causing periapical lesions is Spirochetes. 13. The method according to claim 1, comprising administering the active enamel substance to skin, to a mucosa, to a non-oral tissue, to a surgical incision, or to an internal wound. 14. The method according to claim 13, wherein the mucosa is selected from oral, buccal, nasal, aural, rectal and vaginal mucosa. 15. The method according to claim 1, wherein the active enamel substance is provided on or in a bandage, dressing, drench, patch, sheet, plaster, pad, soap, stick, sponge, transdermal delivery system, or denture. 16. The method according to claim 1, wherein the active enamel substance is provided in a capsule, tablet, pill, pellet, inhalation device, delivery device, spray, aerosol, shampoo, or enema. 17. The method according to claim 1, wherein the active enamel substance is provided as an implant or a coating of an implant. 18. The method according to claim 1, wherein the active enamel substance comprises a peptide comprising at least one sequence element selected from the group consisting of Asp-Gly-Glu-Ala, Val-Thr-Lys-Gly, Glu-Lys-Gly-Glu, and Asp-Lys-Gly-Glu. 19. The method according to claim 18, wherein the active enamel substance further comprises an amino acid sequence comprising a consecutive string of 20 amino acids at least 80% identical with a string of amino acids of the same length obtained from a polypeptide comprising SEQ ID NO. 1, amino acids 1 to 103 of SEQ ID NO. 1, or amino acids 6-324 of SEQ ID NO. 2.
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