IPC분류정보
국가/구분 |
United States(US) Patent
등록
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국제특허분류(IPC7판) |
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출원번호 |
US-0057370
(2002-01-24)
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발명자
/ 주소 |
- Zhou, Peng
- Kuspiel, Edward Joseph
- Ruediger, Waldemar
- Bertok, Alexander
- Trpisovsky, Carl J.
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출원인 / 주소 |
- Bristol-Myers Squibb Company
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대리인 / 주소 |
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인용정보 |
피인용 횟수 :
12 인용 특허 :
3 |
초록
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A bifurcated bracket carries two powder dispensing assemblies. Each assembly includes a powder reservoir and a rotatable screw received within a compliant silicone sleeve. The outer diameter of the screw is slightly larger than the inner diameter of the sleeve such that the screw blade maintains dir
A bifurcated bracket carries two powder dispensing assemblies. Each assembly includes a powder reservoir and a rotatable screw received within a compliant silicone sleeve. The outer diameter of the screw is slightly larger than the inner diameter of the sleeve such that the screw blade maintains direct contact with the sleeve wall as the screw is rotated. The bracket is sequentially moved to align each assembly with containers in two arrays. Each array of containers is situated in a tray. The trays are manually positioned on independent scales which generate signals that are a function of the sensed weight of each array. To fill each container, the screw in the aligned assembly is rotated at a high rate for an initial period and then at a slower rate. The scales are operational only during the slower rate period. Assembly movement and screw rotation are computer controlled.
대표청구항
▼
A bifurcated bracket carries two powder dispensing assemblies. Each assembly includes a powder reservoir and a rotatable screw received within a compliant silicone sleeve. The outer diameter of the screw is slightly larger than the inner diameter of the sleeve such that the screw blade maintains dir
A bifurcated bracket carries two powder dispensing assemblies. Each assembly includes a powder reservoir and a rotatable screw received within a compliant silicone sleeve. The outer diameter of the screw is slightly larger than the inner diameter of the sleeve such that the screw blade maintains direct contact with the sleeve wall as the screw is rotated. The bracket is sequentially moved to align each assembly with containers in two arrays. Each array of containers is situated in a tray. The trays are manually positioned on independent scales which generate signals that are a function of the sensed weight of each array. To fill each container, the screw in the aligned assembly is rotated at a high rate for an initial period and then at a slower rate. The scales are operational only during the slower rate period. Assembly movement and screw rotation are computer controlled. , 59 (5), 1031-1033 (1994). 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SN-1009 to act on a sulfated fucan defined by claim 1 or 2; and collecting a digestion product. 4. The method according to claim 3, wherein the sulfated fucan is derived from Kjellmaniella crassifolia, Laminaria japonica or Lessonia nigrescens. 5. A sulfated fucan oligosaccharide having a chemical structure selected from the group consisting of general formulas (II), (III), (XIII), (XIV), (XV) and (XVI): wherein R is H or SO3H and at least one of Rs is SO3H in all formulas above, or a salt thereof. 7, Plenum Publishing Corporation (1997) U.S. Storhoff, et al., "One-Pot Colorimetric Differentiation of Polynucleotides with Single Base Imperfections Using Gold Nanoparticle Probes," J. Am. Chem. 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Chen & Seeman, "Synthesis from DNA of a molecule with the connectivity of a cube," Nature, vol. 350, pp. 631-633 (1991). Chen et al., Crystal Structure of a Four-Stranded Intercalated DNA: d(C4).dagger..dagger-dbl. Biochem., vol. 33, pp. 13540-13546 (1994). Dagani, "Supramolecular Assemblies DNA to organize gold nanoparticles," Chemical & Engineering News, p. 6-7, Aug. 19, 1996. Dubois & Nuzzo, "Synthesis, Structure, and Properties of Model Organic Surfaces," Annu. Rev. Phys. Chem., vol. 43, pp. 437-464 (1992). Elghanian et al., "Selective Colorimetric Detection of Polynucleotides Based on the Distance-Dependent Optical Properties of Gold Nanoparticles," Science, vol. 277, pp. 1078-1081 (1997). Grabar et al., "Preparation and Characterization of Au Colloid Monolayers," Anal. Chem. vol. 67, pp. 735-743 (1995). Hacia et al., "Detection of heterozygous mutations in BRCA1 using high density oligonucleotide arrays and two-colour fluorescence analysis," Nature Genet., vol. 14, pp. 441-447 (1996). Jacoby, "Nanoparticles change color on binding to nucleotide target," Chemical &Engineering News, p. 10, Aug. 25, 1997. Letsinger et al., Use of Hydrophobic Substituents in Controlling Self-Assembly of Oligonucleotides, J. Am. Chem. Soc., vol. 115, pp. 7535-7536 (1993). Letsinger et al., "Control of Excimer Emission and Photochemistry of Stilbene Units by Oligonucleotide Hybridization," J. Am. Chem. Soc., vol. 116, pp. 811-812 (1994). Marsh et al., "A new DNA nanostructure, the G-wire, imaged by scanning probe microscopy," Nucleic Acids Res., vol. 23, pp. 696-700 (1995). Mirkin, "H-DNA and Related Structures," Annu. Review Biophys. Biomol. Struct., vol. 23, pp. 541-576 (1994). Mirkin et al., "A DNA-based method for rationally assembling nanoparticles into macroscopic materials," Nature, vol. 382, pp. 607-609 (1996). Mirkin et al., "DNA-Induced Assembly of Gold Nanoparticles: A Method for Rationally Organizing Colloidal Particles into Ordered Macroscopic Materials," Abstract 249, Abstracts of Papers Part 1, 212 ACS National Meeting 0-8412-3402-7, American Chemical Society, Orlando, FL, Aug. 25-29, 1996. Mucic et al., "Synthesis and characterizations of DNA with ferrocenyl groups attached to their 5'-termini: electrochemical characterization of a redox-active nucleotide monolayer," Chem. Commun., pp. 555-557 (1996). Mulvaney, "Surface Plasmon Spectroscopy of Nanosized Metal Particles," Langmuir, vol. 12, pp. 788-800 (1996). Rabke-Clemmer et al., "Analysis of Functionalized DNA Adsorption on Au(111) Using Electron Spectroscopy," Langmuir, vol. 10, pp. 1796-1800 (1994). Roubi, "Molecular Machines--Nanodevice with rotating arms assembled from synthetic DNA," Chemical & Engineering News, p. 13, (Jan. 1999). Seeman et al., "Synthetic DNA knots and catenanes," New J. Chem., vol. 17, pp. 739-755 (1993). Shaw & Wang, "Knotting of a DNA Chain During Ring Closure," Science, vol. 260, pp. 533-536 (1993). Shekhtman et al., "Stereostructure of a replicative DNA catenanes from eukaryotic cells," New J. Chem. vol. 17, pp. 757-763 (1993). Smith and Feigon, "Quadruplex structure of Oxytricha telomeric DNA oligonucleotides," Nature, vol. 356, pp. 164-168 (1992). Thein et al., "The use of synthetic oligonucleotides as specific hybridization probes in the diagnosis of genetic disorders," 2ndEd., K.E. Davies, Ed., Oxford University Press, Oxford, New York, Tokyo, p. 21-33 (1993). Wang et al., "Assembly and Characterization of Five-Arm and Six-Arm DNA Brached Junctions," Biochem., vol. 30, pp. 5667-5674 (1991). Wang et al., "A DNA Aptamer Which Binds to and Inhibits Thrombin Exhibits a New Structural Motif for DNA,"Biochem., vol. 32, pp. 1899-1904 (1993). Weisbecker et al., "Molecular Self-Assembly of Alipathic Thiols on Gold Colloids," Langmuir, vol. 12, pp. 3763-3772 (1996). Wells, "Unusual DNA Structures," J. Biol. Chem., vol. 263, pp. 1095-1098 (1988). Zhang et al., "Informational Liposomes: Complexes Derived from Cholesteryl-conjugated Oligonucleotides and Liposomes," Tetrahedron Lett., vol. 37, pp. 6243-6246 (1996). , and conditioned; an MFI comparator coupled to an MFI set point unit, and to a viscometer to measure samples of viscometric melt flow index (MFI) values directly and on-line; wherein a supply of said CTA provided to said reactor is periodically adjusted and CTA concentration of said reactor is closed-loop controlled by said CTA flow regulator as a function of sample MFI determination by said viscometer. 5. The polymerization reactor control apparatus of claim 4, wherein said CTA flow regulator comprises a valve controlled by a flow control signal derived from said CTA flow comparators from a CTA flow set-point control output, based upon a viscometer MFi determination and actual CTA flow input, derived from said CTA flow meter. 6. The polymerization reactor control apparatus of claim 5, wherein a measurement output from said viscometer is coupled to an MFI comparator for comparison with a reference target signal from said MFI set-point unit to produce an MFI correction factor for use by said CTA concentration controller, which issues a set command use by a CTA flow cooperator-controller, to generate flow control output. 7. The reactor control apparatus of claim 6, further including a sensing gas chromatography coupled via a tap line to monitor CTA concentration in said reactor, and to provide a chromatography output signal coupled as an input to said CTA concentration controller. 8. The polymerization reactor control apparatus of claim 4, wherein successive reactor output samples are individually isolated, stabilized, and pressure-conditioned upon transfer from said reactor to said cyclone separator via a sampler. 9. The polymerization reactor control apparatus of claim 4, wherein nitrogen gas (N2) is employed as a sample transfer medium between said reactor and said sample MFI determination viscometer. 10. The polymerization reactor control apparatus; a funnel having an input coupled to an output of said cyclone separator; a ram compaction chamber coupled to an output of said funnel; a compaction ram, movable within said ram compaction chamber; a melted, coupled to said ram compaction chamber; a gear pump coupled to an output of said melted; and a measurement die block, coupled to an output of said gear pump; wherein determination of melt flow index (MFI) is carried out on sample material from said cyclone separator following collection, mixing, and temperature pre-conditioning in said funnel, said sample material being discharged into said compaction chamber, and consolidated by said compaction ram upon said melted, whereupon said gear pump delivers a conditioned sample melt stream to said die block for MFI test flow measurement. 11. The polymerization reactor control apparatus of claim 4, further including an isolation chamber useable as temporary storage of a sample of polymer output, from said reactor, said isolation chamber including: a multiple port rotary valve with a rotary valve member defining a diametral passage, said mutliple port rotatry valve serving as a sample conditioning and transfer chamber that is selectively alignable with circumferential ports, and connected to transfer, condition, discharge, and flush media; wherein upon receiving polymer sample from said isolation chamber, said chamber is connected successively with respective ports, to effect sample conditioning, deactivation and addition of transfer medium, preceding discharge for viscometric determination; wherein further port connection effects vacuum flushing, to purge remaining polymer, and effects valve cooling, following sample discharge. 12. A viscometer for MFI determination in a reactor polymerization control method that includes use of a chain transfer agent (CTA) to determine average polymer chain length by (a) periodically selecting, isolating, and conditioning discrete samples of polymer output from a reactor; (b) measuring samples of viscometric melt flow index (MFI) values directly and on-line; (c) comp
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