IPC분류정보
국가/구분 |
United States(US) Patent
등록
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국제특허분류(IPC7판) |
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출원번호 |
US-0430917
(2003-05-07)
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발명자
/ 주소 |
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대리인 / 주소 |
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인용정보 |
피인용 횟수 :
3 인용 특허 :
22 |
초록
▼
A method for topically treating rosacea is disclosed. In this method, an active material having the formula given below is applied to the patient at the site of said rosacea: wherein R1is selected from —OH and C1-C3alkyl OH; and R2, R3, R4, R5and R6are independently selected from —H, &md
A method for topically treating rosacea is disclosed. In this method, an active material having the formula given below is applied to the patient at the site of said rosacea: wherein R1is selected from —OH and C1-C3alkyl OH; and R2, R3, R4, R5and R6are independently selected from —H, —OH, C1-C6alkyl, and C3-C6cycloalkyl. Preferred active materials include 1,2-cyclohexanediol, 1,3-cyclohexanediol, 1,4-cyclohexanediol, and mixtures of those materials. Methods for treating acne vulgaris, as well as colds, flu, sinusitis, and ear infections, using these actives are also disclosed.
대표청구항
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1. A method of treating rosacea in humans comprising topically applying to a patient in need of such treatment a safe and effective amount of the active compound having the following formula, at the site of said rosacea or where said patient is prone to exhibit rosacea: wherein R 1is selected from &
1. A method of treating rosacea in humans comprising topically applying to a patient in need of such treatment a safe and effective amount of the active compound having the following formula, at the site of said rosacea or where said patient is prone to exhibit rosacea: wherein R 1is selected from —OH, and C1-C3alkyl OH; and R2, R3, R4, R5and R6are each independently selected from —H, —OH, C1-C6alkyl and C3-C6cycloalkyl.2. The method according to claim 1 wherein the active compound is applied to the skin in an amount of from about 0.05 to about 1 mg/cm2.3. The method according to claim 2 wherein the active compound is applied to the skin in a pharmaceutically-acceptable carrier.4. The method according to claim 3 wherein the active compound is selected from cyclohexanol, 2-cyclohexylethanol, cyclohexylmethanol, 3-cyclohexyl-1-propanol, 1,4-cyclohexanediol (cis and/or trans isomers), 1,3 cyclohexanediol (cis and/or trans isomers), 1,2-cyclohexanediol, 4-cyclohexylcyclohexanol, 4-methylcyclohexanol, and mixtures thereof.5. The method according to claim 3 wherein the active compound contains no more than 2 hydroxyl groups.6. The method according to claim 5 wherein the active compound is selected from 1,2-cyclohexanediol, 1,3-cyclohexanediol, 1,4-cyclohexanediol, and mixtures thereof.7. The method according to claim 3 wherein R2, R3, R4, R5and R6are independently selected from —H and —OH.8. The method according to claim 3 wherein the pharmaceutical carrier is selected from propylene glycol, water, dimethylisosorbide, and mixtures thereof.9. The method according to claim 6 wherein the pharmaceutical carrier is selected from propylene glycol, water, dimethylisosorbide, and mixtures thereof.10. A method of treating acne vulgaris in humans comprising topically applying to a patient in need of such treatment a safe and effective amount of a compound selected from 1,3-cyclohexanediol, 1,4-cyclohexanediol, and mixtures thereof. 11. A method for treating conditions characterized by inflammation and allergy symptoms comprising topically applying to a patient in need of such treatment a safe and effective amount of a compound selected from cyclohexanol, 2-cyclohexylethanol, cyclohexylmethanol, 3-cyclohexyl-1-propanol, 1,4-cyclohexanediol (the cis and/or trans isomers), 1,3-cyclohexanediol (the cis and/or trans isomers), 1,2-cyclohexanediol (the cis and/or trans isomers), 4-cyclohexylcyclohexanol, and 4-methylcyclohexanol (the cis and/or trans isomers), and mixtures thereof. 12. The method according to claim 11 wherein the condition is selected from colds, flu, sinusitis, and ear infections.13. The method according to claim 12 wherein the compound is selected from cyclohexanol, 1,3-cyclohexanediol, 1,4-cyclohexanediol, and mixtures thereof.
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