초록 ▼

A stool marker formulation for oral administration and suitable for use in CT Colography including a material adapted to provide marked stool which has a modified response to radiation relative to unmarked stool. Radiologically scanning the colon of a patient treated to produce marked stool produces

A stool marker formulation for oral administration and suitable for use in CT Colography including a material adapted to provide marked stool which has a modified response to radiation relative to unmarked stool. Radiologically scanning the colon of a patient treated to produce marked stool produces data which can be manipulated to provide a representation of the colon including where present, a polyp. The active ingredient is preferably barium sulfate which has been destabilised to reduce its resistance to flocculation.

대표청구항 ▼

1. A liquid stool marker formulation which renders stool opaque to radiation in CT colography, said formulation comprising: from 0 to less than 0.035N ionic dispersants;0.5 to 3% w/v barium sulfate; anda flocculant to flocculate said radio opacifying agent, wherein 20 g of said liquid formulation di

1. A liquid stool marker formulation which renders stool opaque to radiation in CT colography, said formulation comprising: from 0 to less than 0.035N ionic dispersants;0.5 to 3% w/v barium sulfate; anda flocculant to flocculate said radio opacifying agent, wherein 20 g of said liquid formulation diluted with water to 50 ml and titrated against 3.0% w/v ferrous sulfate at pH5.0-5.5 has a flocculation resistance of less than 5 ml.2. A liquid stool marker formulation according to claim 1 wherein the barium sulfate and is administered in an amount less than 7.5 g per dose.3. A liquid stool marker formulation according to claim 1 wherein barium sulfate is present in an amount of 5 g per dose.4. A liquid stool marker formulation according to claim 3 wherein the barium sulfate is present in an amount greater than 1 g per dose.5. A liquid stool marker formulation according to claim 1 wherein the barium sulfate has a particle size of about 3 microns.6. A liquid stool marker formulation according to claim 1 wherein the flocculant is smectite clay.7. A liquid stool marker formulation according to claim 1 further including a viscosity modifier which does not behave as a protective colloid in respect of the material to render stool opaque to radiation.8. A liquid stool marker formulation according to claim 1 further including an anti-caking agent.9. A liquid stool marker formulation according to claim 1 further treated with a treatment selected from the group consisting of high shear stirring and sonification prior to administration to a patient.10. A liquid stool marker formulation according to claim 1 wherein the material to render stool opaque to radiation is present in an amount effective to differentiate stool from non-stool without rendering density or movement induced artefacts in a CT rendering of the stool.11. A liquid stool marker formulation according to claim 1 including (% by weight):Barium Sulfate1.2%Citric Acid Anhydrous0.03%Hydroxypropyl methylcellulose0.45%Smectite Clay0.75%Flavour, Sweetener, Preservativesq.s.Waterq.s. 100%.12. A liquid stool marker formulation according to claim 1 prepared from a solid composition.13. A method of radiologically visualising the colon of a patient including the steps of: orally administering to a patient a stool marker formulation according toclaim 1 to render stool opaque to radiation;radiologically scanning the colon of the patient to produce data; andmanipulating the data to determine that portion of the data due to marked stool, to thereby provide a representation of the colon, including where present, a polyp.14. A method according to claim 13 wherein the radiological visualisation is by means of a CT scanner.15. A method according to claim 13 wherein the radiological visualisation is by means of a helical scanner.16. A method according to claim 13 wherein the manipulation of the data involves subtraction of that portion of the data due to the marked stool, leaving a representation of the colon, including where present a polyp.17. A method of preparing a patient for a radiological examination including the step of administering to the patient a formulation according to claim 1 to render stool opaque to radiation.18. A method according to claim 13 wherein the formulation is administered orally over 24 to 48 hours preceding the radiological examination.19. A method according to claim 13 wherein the formulation is administered in four or more dosages over 24 to 48 hours preceding the radiological examination.