Analysis and control of parallel chemical reactions
원문보기
IPC분류정보
국가/구분
United States(US) Patent
등록
국제특허분류(IPC7판)
G01N-031/10
B01J-019/00
출원번호
US-0723720
(2000-11-28)
발명자
/ 주소
Wang, Pei
Dales, G. Cameron
출원인 / 주소
Symyx Technologies, Inc.
대리인 / 주소
Senniger, Powers, Leavitt & Roedel
인용정보
피인용 횟수 :
12인용 특허 :
83
초록▼
Computer programs and computer-implemented methods for monitoring the progress and properties of parallel chemical reactions. The invention repeatedly receives a measured value or values associated with the contents of each of a plurality of reactor vessels and displays the measured over the course
Computer programs and computer-implemented methods for monitoring the progress and properties of parallel chemical reactions. The invention repeatedly receives a measured value or values associated with the contents of each of a plurality of reactor vessels and displays the measured over the course of a combinatorial chemical reaction. Reaction parameters associated with individual reactor vessels are changed in response to the value measured during the reaction. Reaction parameters include temperature, pressure, stirring speed. The reaction occurring in one or more reactor vessels is quenched in response to values measured during the reaction. The measured values are used to calculate experimental results including temperature change, pressure change, percent conversion of starting material, and viscosity. The measured values and experimental results are displayed. In another aspect, the invention features a method for controlling a combinatorial chemical reactor. The method includes receiving set points for properties associated with the reaction environment in multiple reactor vessels, measuring experimental values associated with each reactor vessel, displaying the experimental values, and changing the vessels' reaction environment in response to input set points and changing experimental values. In another aspect, the invention features a reactor control system for monitoring and controlling a parallel chemical reaction. The system includes modules for providing control signals to a parallel chemical reactor, receiving measured values from the parallel chemical reactor and calculating experimental results from the measured values, and for receiving reaction parameters from the user and displaying the set of measured values and the calculated values.
대표청구항▼
Computer programs and computer-implemented methods for monitoring the progress and properties of parallel chemical reactions. The invention repeatedly receives a measured value or values associated with the contents of each of a plurality of reactor vessels and displays the measured over the course
Computer programs and computer-implemented methods for monitoring the progress and properties of parallel chemical reactions. The invention repeatedly receives a measured value or values associated with the contents of each of a plurality of reactor vessels and displays the measured over the course of a combinatorial chemical reaction. Reaction parameters associated with individual reactor vessels are changed in response to the value measured during the reaction. Reaction parameters include temperature, pressure, stirring speed. The reaction occurring in one or more reactor vessels is quenched in response to values measured during the reaction. The measured values are used to calculate experimental results including temperature change, pressure change, percent conversion of starting material, and viscosity. The measured values and experimental results are displayed. In another aspect, the invention features a method for controlling a combinatorial chemical reactor. The method includes receiving set points for properties associated with the reaction environment in multiple reactor vessels, measuring experimental values associated with each reactor vessel, displaying the experimental values, and changing the vessels' reaction environment in response to input set points and changing experimental values. In another aspect, the invention features a reactor control system for monitoring and controlling a parallel chemical reaction. The system includes modules for providing control signals to a parallel chemical reactor, receiving measured values from the parallel chemical reactor and calculating experimental results from the measured values, and for receiving reaction parameters from the user and displaying the set of measured values and the calculated values. beta galactosidase enzyme according to claim 7, having a stable enzymatic activity in the presence of at least one substance selected from the group consisting of calcium and galactose.11. The purified cold-active beta galactosidase enzyme according to claim 7, having a stable enzymatic activity at a temperature lower than 6° C.12. The purified cold-active beta galactosidase enzyme according to claim 7, having a stable enzymatic activity at a temperature of 4° C.13. The purified cold-active beta galactosidase enzyme according to claim 6, having a stable enzymatic activity at a temperature lower than 6° C.14. The purified cold-active beta galactosidase enzyme according to claim 6, having a stable enzymatic activity at a temperature of 4° C.15. The purified cold-active beta galactosidase enzyme according to claim 6, being inactivated at pasteurization temperatures.16. The purified cold-active beta galactosidase enzyme according to claim 6, having a stable enzymatic activity at a pH ranging from 6 to 10.17. The purified cold-active beta galactosidase enzyme according to claim 6, having a stable enzymatic activity in the presence of at least one substance selected from the group consisting of calcium and galactose.18. The purified cold-active beta galactosidase enzyme according to claim 6, having a stable enzymatic activity at a refrigerating conservation temperature for dairy products.19. A purified cold-active beta galactosidase enzyme, having stable enzymatic activity between 0° C. and 50° C., in the presence of lactose, said enzyme being produced by the psychrophilic bacterium Pseudoalteromonas haloplanktisgiven the BCCM™ Accession Number LMG P-19143.20. A purified cold-active beta galactosidase enzyme, having stable enzymatic activity between 0° C. and 50° C., in the presence of lactose, said enzyme being produced by the psychrophilic bacterium Pseudoalteromonas haloplanktisgiven the BCCM™ Accession Number LMG P-19143, and having a stable enzymatic activity in the presence of at least one substance selected from the group consisting of calcium and galactose.21. A method for producing a cold-active beta galactosidase enzyme according to claim 1, comprising the steps of:extracting nucleic acids fromPseudoalteromonas haloplanktis,constructing a recombinant expression vector comprising a nucleic acid which encodes said cold-active beta galactosidase enzyme,transforming a host cell with at least one such said recombinant expression vector,culturing said transformed host, andrecovering the produced polypeptide having the biological activity of said cold-active beta galactosidase enzyme.22. A method for reducing lactose content in dairy products, comprising the step of: contacting the dairy product with a purified cold-active beta galactosidase enzyme according toclaim 1, at a refrigeration temperature and at a pH ranging from 6-10.23. The method according to claim 22, further comprising the step of heating said contacted dairy product at a pasteurization temperature sufficient to denature said cold-active beta galactosidase enzyme.24. The purified cold-active beta galactosidase enzyme according to claim 1, which is efficacious for hydrolyzing lactose in milk or dairy products at a temperature below 8° C. claim 1 wherein the penta-tolerant fungus isAntrodia radiculosa(L-11659-sp).3. The fungal inoculum of claim 1 wherein the lignocellulosic substrate is selected from the group consisting of sawdust, wood chips, rice straw, corn stalks, and wheat straw.4. The fungal inoculum of claim 1 wherein the nutrient supplement is selected from the group consisting of corn steep liquor, cornmeal and wheatbran.5. The fungal inoculum of claim 1 wherein the penta-tolerant fungus is selected from the group consisting ofAntrodia radiculosa(FP-103272-sp) andAntrodia radiculosa(L-11659-sp).6. A method for preparing a fungal inoculum for degrading or bioremediating wood containing pentachlorophenol (penta), comprising the steps of: combining at least one penta-tolerant fungus selected from the group consisting ofMeruliporia incrassata(Mad-563),Antrodia radiculosa(FP-103272-sp),Antrodia radiculosa(L-11659-sp) andAntrodia radiculosa(FP-90848-T) with a matrix comprising at least one lignocellulosic substrate, at least one nutrient supplement, and the lignocellulosic substrate and the nutrient supplement in an amount sufficient to produce a biomass of the fungal inoculum sufficient to at least partially remediate the penta and sterile water; andgrowing the penta-tolerant fungus and matrix combination in dark, aerobic conditions, at a relative humidity of about 70%, and in a temperature range of about 20° C. to 35° C.7. The method of claim 6 wherein the penta-tolerant fungus and matrix combination is grown in a temperature range of about 25° C. to 32° C.8. The method of claim 6 wherein the lignocellulosic substrate is about 25% to 33% the volume of sterile water, and the volume of nutrient supplement is about 1% to 5% the volume of sterile water.
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