초록 ▼

A small implantable stimulator(s) includes at least two electrodes for delivering electrical stimulation to surrounding tissue and/or a pump and at least one outlet for delivering a drug or drugs to surrounding tissue. One electrochemotherapy method disclosed includes delivery of electrical stimulat

A small implantable stimulator(s) includes at least two electrodes for delivering electrical stimulation to surrounding tissue and/or a pump and at least one outlet for delivering a drug or drugs to surrounding tissue. One electrochemotherapy method disclosed includes delivery of electrical stimulation in the form of a direct electric current and/or a periodic waveform that locally potentiates the cytotoxic effects of a systemically and/or locally administered chemotherapy agent(s). Open- and closed-loop systems are disclosed.

대표청구항 ▼

A small implantable stimulator(s) includes at least two electrodes for delivering electrical stimulation to surrounding tissue and/or a pump and at least one outlet for delivering a drug or drugs to surrounding tissue. One electrochemotherapy method disclosed includes delivery of electrical stimulat

A small implantable stimulator(s) includes at least two electrodes for delivering electrical stimulation to surrounding tissue and/or a pump and at least one outlet for delivering a drug or drugs to surrounding tissue. One electrochemotherapy method disclosed includes delivery of electrical stimulation in the form of a direct electric current and/or a periodic waveform that locally potentiates the cytotoxic effects of a systemically and/or locally administered chemotherapy agent(s). Open- and closed-loop systems are disclosed. 9951000, Chin, 606/192; US-5469853, 19951100, Law et al., 128/662.06; US-5472441, 19951200, Edwards et al., 606/041; US-5478558, 19951200, Eibl et al., 424/094.63; US-5484398, 19960100, Stoddard, 604/022; US-5498236, 19960300, Dubrul et al., 604/022; US-5516043, 19960500, Manna et al., 239/102.2; US-5580962, 19961200, Eibl et al., 530/395; US-5603445, 19970200, Hill et al., 228/004.5; US-5628743, 19970500, Cimino, 606/001; US-5630837, 19970500, Crowley, 601/002; US-5672172, 19970900, Zupkas, 606/020; US-5676649, 19971000, Boukhny et al., 604/022; US-5713848, 19980200, Dubrul et al., 604/022; US-5720710, 19980200, Tachibana et al., 601/002; US-5725494, 19980300, Brisken, 604/022; US-5728062, 19980300, Brisken, 604/022; US-5735811, 19980400, Brisken, 604/022; US-5741225, 19980400, Lax et al., 604/022; US-5772627, 19980600, Acosta et al., 604/022; US-5827203, 19981000, Nita, 601/002; US-5836896, 19981100, Rosenschein, 601/002; US-5836897, 19981100, Sakurai et al., 601/002; US-5843017, 19981200, Yoon, 604/022; US-5846218, 19981200, Brisken et al., 604/022; US-