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특허 상세정보

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Liquid polymeric compositions for controlled release of bioactive substances

특허상세정보
국가/구분 United States(US) Patent 등록
국제특허분류(IPC7판) A61K-009/00   
미국특허분류(USC) 424/426; 424/424; 424/425; 424/422; 424/457; 424/458; 424/459; 424/489; 424/423; 604/891.1
출원번호 US-0271098 (1999-03-18)
발명자 / 주소
출원인 / 주소
대리인 / 주소
    Desai, Mitul I.
인용정보 피인용 횟수 : 9  인용 특허 : 108
초록

Controlled release of hydrophobic bioactive substances in vivo over an extended time period and without “bursts” of drug release is achieved using a liquid polymeric composition including a polymer such as poly(lactide-co-glycolide) copolymer in a mixture of hydrophilic and lipophilic solvents.

대표
청구항
▼

1. A liquid polymeric composition for controlled release of eprinomectin consisting essentially of: (a) 1 to 10% of eprinomectin; (b) 1 to 10% of a poly(lactide-co-glycolide) copolymer; wherein the weight ratio of the poly(lactide-co-glycolide) copolymer to the eprinomectin is 1:1 or less and the ratio of lactide:glycolide of the poly(lactide-co-glycolide) copolymer is from about 75:25 to about 65:35; and (c) at least one lipophilic solvent or a mixture of hydrophilic and lipophilic solvents, wherein the volume ratio of the hydrophilic and lipoph...

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