IPC분류정보
국가/구분 |
United States(US) Patent
등록
|
국제특허분류(IPC7판) |
|
출원번호 |
US-0907109
(2001-07-16)
|
우선권정보 |
EP-0200130 (1999-01-19) |
발명자
/ 주소 |
- Fritsche, Rodolphe
- Pecquet, Sophie
- Bovetto, Lionel
- Maynard, Francoise
|
출원인 / 주소 |
|
대리인 / 주소 |
|
인용정보 |
피인용 횟수 :
4 인용 특허 :
1 |
초록
▼
A hypoallergenic composition for the induction of protein tolerance in at risk individuals of protein allergy. The composition contains (i) a “non allergenic” protein extensively hydrolyzed basis and/or of (ii) a free amino acid basis. The composition contains, as an active ingredient, at least one
A hypoallergenic composition for the induction of protein tolerance in at risk individuals of protein allergy. The composition contains (i) a “non allergenic” protein extensively hydrolyzed basis and/or of (ii) a free amino acid basis. The composition contains, as an active ingredient, at least one tolerogenic peptide of the allergenic protein.
대표청구항
▼
A hypoallergenic composition for the induction of protein tolerance in at risk individuals of protein allergy. The composition contains (i) a “non allergenic” protein extensively hydrolyzed basis and/or of (ii) a free amino acid basis. The composition contains, as an active ingredient, at least one
A hypoallergenic composition for the induction of protein tolerance in at risk individuals of protein allergy. The composition contains (i) a “non allergenic” protein extensively hydrolyzed basis and/or of (ii) a free amino acid basis. The composition contains, as an active ingredient, at least one tolerogenic peptide of the allergenic protein. oglobulin.5. The composition of claim 1, which further comprises a source of nitrogen providing 7 to 25% of the total energy, a source of carbohydrates which provides 28 to 66% of the total energy, a source of lipids which provides 25 to 60% of the total energy, minerals and vitamins to meet daily requirements and at least one of the tolerogenic peptides that is added in an efficient quantity so as to induce oral tolerance.6. A method for the preparation of a hypoallergenic composition intended for administration to mammals susceptible to cow's milk allergy, comprising preparing a free amino acid base or an extensively hydrolyzed protein material to form a “non-allergenic base composition and incorporating into the non-allergenic base composition, at least one isolated tolerogenic peptide fraction or at least one synthetically prepared tolerogenic peptide of a milk protein in an amount sufficient to induce tolerance to milk proteins. 7. The method of claim 6, wherein the tolerogenic peptide is at least one tolerogenic peptide of the allergenic protein.8. The method of claim 6, wherein the tolerogenic peptide is from milk origin.9. The method of claim 8, wherein the tolerogenic peptide is from ß-lactoglobulin, α-lactalbumin, bovin serum albumin or casein origin.10. The method of claim 6, wherein the tolerogenic peptide comprises: H2N-I-D-A-L-N-E-N-K-COOH, H2N-V-L-V-L-D-T-D-Y-K,-K-COOH or H2N-T-P-E-V-D-D-E-A-L-E-K-F-D-K-COOH from ß-lactoglobulin.11. The method of claim 6, wherein the composition contains a source of nitrogen which provides 7 to 25% of the total energy, a source of carbohydrates which provides 28 to 66% of the total energy, a source of lipids which provides 25 to 60% of the total energy, and, optionally, minerals and vitamins to meet daily requirements.12. The method of claim 11, wherein the effective amount of the tolerogenic peptide is at least about 0.01% to 10% of the total nitrogen source of the protein.13. The method of claim 6, wherein the isolated tolerogenic peptide fraction is in an amount to provide a ratio of tolerogenic response to residual antigenicity of at least about 2×10−2, wherein native protein residual antigenicity is 106and a tolerogenic response is 1.14. The method of claim 6, wherein the tolerogenic peptide comprises H2N-I-D-A-L-N-E-N-K-COOH, H2N-V-L-V-L-D-T-D-Y-K,-K-COOH or H2N-T-P-E-V-D-D-E-A-L-E-K-F-D-K-COOH from ß-lactoglobulin.15. The method of claim 6, wherein the hypoallergenic composition includes a source of nitrogen providing 7 to 25% of the total energy, a source of carbohydrates which provides 28 to 66% of the total energy, a source of lipids which provides 25 to 60% of the total energy, minerals and vitamins to meet daily requirements and at least one of the tolerogenic peptides that is added in an efficient quantity so as to induce oral tolerance.16. A method of preparing the composition of claim 1, comprising preparing the hypoallergenic compositions containing the extensively hydrolyzed “non allergenic” protein material or the free amino acid basis and incorporating into such composition, as the active ingredient at least one tolerogenic peptide.
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