IPC분류정보
국가/구분 |
United States(US) Patent
등록
|
국제특허분류(IPC7판) |
|
출원번호 |
US-0974474
(2001-12-14)
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발명자
/ 주소 |
- Schroeppel, Edward A.
- Kroll, Mark W.
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출원인 / 주소 |
- OncoStim, A Minnesota corporation
|
대리인 / 주소 |
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인용정보 |
피인용 횟수 :
148 인용 특허 :
19 |
초록
▼
An implantable electrical method and apparatus for the treatment of cancer tumors based on the usage of various levels of electrical fields and current to assist in specific ways to reduce tumor size. The appropriate voltage, currents, and time duration as well as the usage of adjunctive pharmacolog
An implantable electrical method and apparatus for the treatment of cancer tumors based on the usage of various levels of electrical fields and current to assist in specific ways to reduce tumor size. The appropriate voltage, currents, and time duration as well as the usage of adjunctive pharmacological therapy are taught.
대표청구항
▼
An implantable electrical method and apparatus for the treatment of cancer tumors based on the usage of various levels of electrical fields and current to assist in specific ways to reduce tumor size. The appropriate voltage, currents, and time duration as well as the usage of adjunctive pharmacolog
An implantable electrical method and apparatus for the treatment of cancer tumors based on the usage of various levels of electrical fields and current to assist in specific ways to reduce tumor size. The appropriate voltage, currents, and time duration as well as the usage of adjunctive pharmacological therapy are taught. e incident points. 7. The system of claim 1, wherein, k. said means for producing an indicator includes means for producing an indicator for an enclosed material in said path of radiation, enclosed by an enclosing material, in said path of radiation. 8. The system of claim 7, wherein, said means for producing an indicator includes detecting and data acquisition means for producing an indicator of the size, location or image of said enclosed material enclosed by said enclosing material.9. The system of claim 8, wherein, said detecting and data acquisition means includes means for producing data displaying separate amplitudes for respective incident points in said radiation path and the corresponding optical distances t* of said respective incident points.10. The system of claim 1, wherein, said means for producing an indicator, comprises, l. means for producing data of the reflected radiation amplitudes of the respective incident points correlated with the optical distance t* to the respective incident points; m. means for displaying said indicator as a change in said data at an interface between an enclosed material enclosed by an enclosing material, of said plurality of materials. 11. The system of claim 10, wherein, said means for producing said indicator includes means for producing a single pulse of radiation, and said means for producing data includes means for receiving said reflected radiation substantially about the axis of said path of radiation.12. The system of claim 1, wherein, n. said means for producing said radiation includes means for producing a single pulse of radiation; and o. said means for producing an indicator includes means for producing an indicator in response to said single pulse of radiation for at least one of said plurality of materials in said radiation path. 13. The system of claim 1, wherein, p. said means for producing radiation includes a plurality of means for producing radiation in a plurality of radiation paths and said means for receiving said reflected radiation includes a plurality of means for receiving reflected radiation from said plurality of radiation paths; q. means for operating said plurality of means for producing radiation in a plurality or radiation paths and for operating said plurality of means for receiving reflected radiation from said plurality of radiation paths; r. said means for producing an indicator includes means connected to said plurality of means for receiving reflected radiation from said plurality of radiation paths, and responsive to said reflected radiation, for producing said indicator from said reflected radiation from said plurality of radiation paths. 14. A method for optical imaging using a pulse of radiation in a radiation path to an enclosed material within a non-homogeneous body and responsive to reflected radiation, producing an indicator for said enclosed material, comprising, a. producing one or more pulses of radiation, to radiate a plurality of materials with varying scattering mediums within a non-homogeneous body, in a radiation path, with at least one pulse of radiation of a temporal pulse width t p; b. selecting said laser temporal pulse width t pin relation to a combined factor tp*=&kgr;·c·tpfor a minimum value for said combined factor tp* or for a value of said combined factor tp* no greater than about 1, where &kgr; represents said extinction coefficient of said scattering mediums, and c represents the propagation speed of light radiation through said scattering mediums; c. receiving said reflected radiation from respective incident points located in said radiation path; d. producing an indicator for at least one material in said radiation path, responsive to said radiation reflected by said respective incident points. 15. The method of claim 13, wherein, said step of producing said indicator includes, e. producing an indicator of the location of at least one of said respective incident points. 16. The m ethod of claim 13, wherein said step of producing said indicator includes, f. producing an indicator of the optical distance of said respective incident points. 17. The method of claim 16, wherein said step of producing an indicator of the optical distance includes, g. producing data indicative of the amplitude of said radiation reflected from said respective incident points and data indicative of the optical distance t* to said respective incident point, where the optical distance to said respective incident point is t*=&kgr;·c·t, and where I represents the distance of said radiation path to said respective incident point and where the effective time t of propagation for said respective incident point is t=2I/c. 18. The method of claim 13, wherein, h. said step of producing one or more pulses of radiation includes the step of producing a single pulse of radiation; and i. said step of producing an indicator includes the step of producing said indicator in response to said single pulse of radiation. 19. The method of claim 13, wherein, said step of producing an indicator comprises, j. producing an indicator indicative of the amplitude of said reflected radiation from said respective incident points and of the optical distance t* to said respective incident points. 20. The method of claim 13, wherein, k. said step of producing an indicator includes the step of producing an indicator for an enclosed material in said path of radiation, enclosed by an enclosing material, in said path of radiation. 21. The method of claim 20, wherein, said step of producing an indicator includes the step of producing a indicator of the size, location or image of said enclosed material enclosed by said enclosing material.22. The method of claim 20, wherein, said step of producing an indicator includes the step of producing data displaying separate amplitudes for respective incident points in said radiation path and the corresponding optical distances t* of said respective incident points.23. The method of claim 13, wherein, said step of producing an indicator, comprises, l. producing data of the reflected radiation amplitudes of the respective incident points correlated with the optical distance t* to the respective incident points; m. displaying said indicator as a change in said data at an interface between an enclosed material enclosed by an enclosing material, of said plurality of materials. 24. The method of claim 23 wherein, said step of producing said indicator includes the step of producing a single pulse of radiation, and said step of producing data includes the step of receiving said reflected radiation substantially about the axis of said path of radiation.25. The method of claim 13, wherein, n. said step of producing said radiation includes the step of producing a single pulse of radiation; and o. said step of producing an indicator includes the step of producing an indicator in response to said single pulse of radiation for at least one of said plurality of materials in said radiation path. 26. The method of claim 13, wherein, p. said step of producing radiation includes the step of producing radiation in a plurality of radiation paths and said step of receiving said reflected radiation includes the step of receiving reflected radiation from said plurality of radiation paths; q. said step of producing an indicator includes the step of receiving reflected radiation from said plurality of radiation paths, and responsive to said reflected radiation, producing said indicator from said reflected radiation from said plurality of radiation paths. 27. An Optical Imaging Apparatus Using A Temporal Direct Reflectance Signal, for detecting in a non-homogeneous body, one or more interfaces between a first material and a second material, with different scattering characteristics relative to each other, comprising, a laser operative to produce light in one or more pulses of light radiation, in a light path directed on a
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