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A hydrophilic membrane having a low adsorptivity for a protein is disposed, as an interface, on a side to be contacted with a skin, and a drug such as a physiologically active peptide is transdermally delivered by iontophoresis. The membrane has an adsorptivity for a protein of not greater than 10 &

A hydrophilic membrane having a low adsorptivity for a protein is disposed, as an interface, on a side to be contacted with a skin, and a drug such as a physiologically active peptide is transdermally delivered by iontophoresis. The membrane has an adsorptivity for a protein of not greater than 10 &mgr;g/cm2. The thickness of the membrane is about 10 to 200 &mgr;m, and the porosity of the membrane is about 60 to 90%. Such membrane includes a hydrophilized fluororesin membrane, a hydrophilized polysulfone membrane and a hydrophilized cellulose derivative membrane.

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1. An interface for iontophoresis which comprises a membrane having a low adsorptivity for a protein, wherein the membrane is (1) a hydrophilized fluororesin membrane of a homo- or co-polymer composed of a fluorine-containing monomer having a hydrophilic group as a constitutive unit, (2) a hydrophil

1. An interface for iontophoresis which comprises a membrane having a low adsorptivity for a protein, wherein the membrane is (1) a hydrophilized fluororesin membrane of a homo- or co-polymer composed of a fluorine-containing monomer having a hydrophilic group as a constitutive unit, (2) a hydrophilized polysulfone membrane incorporating a wetting agent or (3) a hydrophilized cellulose derivative membrane. 2. The interface as claimed in claim 1, wherein the fluorine-containing monomer is a fluoroethylene having a hydrophilic group or a vinylidene fluoride having a hydrophilic group.3. The interface as claimed in claim 1, wherein the hydrophilized fluororesin is at least one member selected from the group consisting of a polyfluoroethylene, a fluoroethylene-tetrafluoroethylene copolymer, a fluoroethylene-hexafluoropropylene copolymer, an ethylene-fluoroethylene copolymer, an ethylene-chlorotrifluoroethylene copolymer, a poly(vinylidene flouride, a fluoroethylene-vinylidene fluoride copolymer and an ethylene-vinylidene fluoride copolymer, and is introduced with a hydrophilic group.4. The interface as claimed in claim 1, wherein the hydrophilic group is at least one member selected from the group consisting of a hydroxyl group, a carboxyl group, an amino group, a mono- or di-C1-4alkylamino group, an ether group, a hydroxy-C1-4alkyl group, a carboxy-C1-4alkyl group, an amino-C1-4alkyl group and a mono- or di-C1-4alkylamino-C1-4alkyl group.5. The interface as claimed in claim 1, wherein the hydrophilic group is a hydroxy-C2-3alkyl group or a (poly)oxyalkylene group.6. The interface as claimed in claim 1, wherein the membrane has an adsorptivity for a protein of 0 to 10 &mgr;g per 1 cm2.7. The interface as claimed in claim 1, wherein the membrane has a thickness of 1 to 300 &mgr;m.8. The interface as claimed in claim 1, wherein the membrane is a porous membrane having pores with a mean pore size of 0.01 to 20 &mgr;m.9. The interface as claimed in claim 1, wherein the membrane has a porosity of 60 to 90%.10. The interface as claimed in claim 1, wherein the ionic surfactant is a cationic surfactant.11. The interface as claimed in claim 1, wherein the ionic surfactant is a quaternary ammonium salt.12. The interface as claimed in claim 1, wherein the ionic surfactant is an alkylbenzyldimethylammonium halide shown by the following formula[C 6H5CH2N(CH3)2R]+X− wherein R represents an alkyl group and X represents a halogen atom. 13. The interface as claimed in claim 1, wherein the membrane has a thickness of 10 to 200 &mgr;m and an area of 1 to 10 cm2.14. The interface as claimed in claim 1, wherein the hydrophilized fluororesin membrane is a poly(vinylidene flouride) and wherein the hydrophilic group is a hydroxy-C2-3alkyl group.