Apparatus for generalized extracorporeal support
원문보기
IPC분류정보
국가/구분
United States(US) Patent
등록
국제특허분류(IPC7판)
A61M-037/00
A61M-001/36
출원번호
US-0741625
(2000-12-19)
발명자
/ 주소
Spears, J. Richard
Foerster, Seth A.
Gessert, James M.
Zalesky, Paul J.
대리인 / 주소
Kivinski, Margaret A.
인용정보
피인용 횟수 :
15인용 특허 :
59
초록▼
A system and method for increasing gas concentration in blood which has use as a generalized extracorporeal system and method to treat hypoxemic blood from a patient by mixing the blood with an oxygen supersaturated solution to generate hyperoxemic blood to be infused back to the patient. The extrac
A system and method for increasing gas concentration in blood which has use as a generalized extracorporeal system and method to treat hypoxemic blood from a patient by mixing the blood with an oxygen supersaturated solution to generate hyperoxemic blood to be infused back to the patient. The extracorporeal system comprises an extracorporeal tubing through which blood from the patient is circulated, a blood pump for withdrawing blood from and delivering blood to the patient, at least one channel for delivering oxygen-supersaturated fluid and a mixing region for introducing supersaturated fluid without bubble formation. By infusing the oxygen-supersaturated fluid into the hypoxemic or normoxemic blood from the patient, hyperoxemic blood is thereby produced. The hyperoxemic blood is then returned to a central vein, right heart or artery of the patient with the blood pump at approximately the same volume delivery rate as blood volume withdrawal rate.
대표청구항▼
1. A system for introducing gas-supersaturated fluid into blood of a patient, comprising: an extracorporeal blood circulation circuit adapted to receive, circulate and return blood to the patient; at least one channel opening into said circuit for delivering gas-supersaturated fluid to said cir
1. A system for introducing gas-supersaturated fluid into blood of a patient, comprising: an extracorporeal blood circulation circuit adapted to receive, circulate and return blood to the patient; at least one channel opening into said circuit for delivering gas-supersaturated fluid to said circuit; and means for introducing gas-supersaturated fluid into blood in said circuit while minimizing bubble formation. 2. The system of claim 1, wherein said introducing means comprises means for controlling fluid flow to minimize turbulence at the point of introduction of gas-supersaturated fluid into the blood flow, including a mixing region defined by a flow passage with an inner wall, an upstream entry and a downstream exit.3. The system of claim 2, wherein said controlling means comprises said at least one channel opening being positioned on the flow passage inner wall wherein said at least one channel is disposed at a predetermined angle to the blood flow to minimize turbulence at the point of gas-supersaturated fluid introduction.4. The system of claim 3, wherein said predetermined angle is approximately 45 degrees.5. The system of claim 3, wherein said flow passage inner wall tapers from a larger inner diameter at the entry to a smaller inner diameter at the exit and said channel opening is positioned on the inner wall in said larger inner diameter.6. The system of claim 3, further comprising a plurality of channels approximately equally spaced around the flow passage inner wall.7. The system of claim 2, wherein said controlling means comprises a fin member disposed centrally within the mixing region flow passage with said at least one channel opening disposed on said fin member to align flow of gas-supersaturated fluid introduced into the blood with the blood flow.8. The system of claim 2, wherein said mixing region comprises a stiffening member to maintain said region substantially in axial alignment with the blood flow.9. The system of claim 2, wherein said blood circulation circuit has an average inner diameter and the mixing region flow passage exit inner diameter is approximately equal to said circuit inner diameter.10. The system of claim 2, wherein said introducing means further comprises a chamber for accumulating blood disposed upstream of the mixing region, said chamber having a volume, a blood flow input to receive blood from said circuit and a output communicating with the mixing region entry, wherein said chamber volume, input and output are sized, in cooperation with the mixing region, such that blood flow through the mixing region is substantially constant.11. The system of claim 1, wherein said circuit comprises tubing having a system input and a system output and a pump providing blood flow at a predetermined rate through said tubing and wherein said introducing means is in fluid communication with said tubing.12. The system of claim 11, further comprising an intravascular catheter connected to the system output for delivering blood from said circuit to a desired location within the patient.13. The system of claim 12, further comprising a catheter introducer having a y-connector for introducing said catheter into the patients vasculature, wherein the system input is connected to said y-connector for receiving blood from the patient.14. The system of claim 11, further comprising a first gas sensor in fluid communication with the tubing upstream of the introducing means to sense gas in blood received from the patient and a second gas sensor in fluid communication with the tubing downstream of the introducing means to sense gas in blood to be returned to the patient.15. The system of claim 14, wherein the first gas sensor monitors oxyhemoglobin saturation level of the blood and the second sensor measures the oxygen partial pressure of the blood.16. The system of claim 11, further comprising a shunt loop in fluid communication with the circuit tubing.17. The system of claim 11, wherein said predetermined bl ood flow rate is between 25-8000 ml/mm.18. The system of claim 11, wherein the tubing has an inner blood passivating surface.19. The system of claim 11, further comprising a filter in fluid communication with said tubing the introducing means to filter at least a portion of the fluid introduced from the blood.20. The system of claim 1, further comprising a source of aqueous oxygen having an oxygen concentration of at least 0.5 ml oxygen/ml fluid communicating with said at least one channel, wherein the oxygen volume is normalized to standard temperature and pressure.21. An extracorporeal blood circulation system comprising: an extracoropreal blood circulation circuit, the circuit having a first channel adapted to receive blood from a patient, the circuit having a second channel adapted to deliver oxygenated fluid into the blood to form oxygenated blood, and the circuit having a third channel adapted to deliver the oxygenated blood to the patient. 22. The system, as set forth in claim 21, wherein the third channel comprises a mixing region in which the blood from the first channel and the oxygenated fluid from the second channel mix to form the oxygenated blood.23. The system, as set forth in claim 22, wherein the mixing region comprises a straight tube.24. The system, as set forth in claim 21, comprising: an oxygenated fluid delivery device operatively coupled to deliver the oxygenated fluid to the second channel. 25. The system, as set forth in claim 21, comprising: a pump operatively coupled to the circuit to circulate the blood through the circuit. 26. The system, as set forth in claim 21, wherein the oxygenated blood comprises normoxemic blood.27. The system, as set forth in claim 21, wherein the oxygenated blood comprises hyperoxemic blood.28. The system, as set forth in claim 21, wherein the first channel is operatively coupled to a catheter.29. The system, as set forth in claim 21, wherein the third channel is operatively coupled to a catheter.30. The system, as set forth in claim 21, wherein the oxygenated fluid comprises oxygen-supersaturated fluid.31. The system, as set forth in claim 21, comprising at least one oxygen level sensor disposed in at least one of the channels.32. The system, as set forth in claim 21, wherein the oxygenated fluid comprises aqueous oxygen.33. An extracorporeal blood circulation system comprising: an extracorporeal blood circulation circuit, the circuit having a first channel adapted to receive blood from a patient, the circuit having a second channel adapted to deliver gas-supersaturated fluid into the blood to form blood with increased gas concentration, and the circuit having a third channel adapted to deliver the blood with increased gas concentration to the patient. 34. The system, as set forth in claim 33, wherein the third channel comprises a mixing region in which the blood from the first channel and the gas-supersaturated fluid from the second channel mix to form the blood with increased gas concentration.35. The system, as set forth in claim 34, wherein the mixing region comprises a straight tube.36. The system, as set forth in claim 33, wherein the blood with increased gas concentration comprises oxygen-enriched blood.37. The system, as set forth in claim 36, wherein the oxygen-enriched blood comprises hyperoxemic blood.38. The system, as set forth in claim 33, comprising: a gas-supersaturated fluid delivery device operatively coupled to deliver the gas-supersaturated fluid to the second channel. 39. The system, as set forth in claim 33, comprising: a pump operatively coupled to the circuit to circulate the blood through the circuit. 40. The system, as set forth in claim 33, wherein the first channel is operatively coupled to a catheter.41. The system, as set forth in claim 33, wherein the third channel is operatively coupled to a catheter.42. The system, as set forth in claim 33, wherein the gas-supersaturated fluid comprises oxygen-supersaturated fluid.43. The sys tem, as set forth in claim 33, comprising at least one gas level sensor disposed in at least one of the channels.44. The system, as set forth in claim 33, wherein the gas-supersaturated fluid comprises aqueous oxygen.
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