초록 ▼

A transdermal delivery system (TDS) having: a carrier layer (cover layer) impermeable to the substances/active ingredients to be delivered; a membrane permeable to the substances/active ingredients to be delivered; a reservoir containing substances/active ingredients to be delivered, the reservoir b

A transdermal delivery system (TDS) having: a carrier layer (cover layer) impermeable to the substances/active ingredients to be delivered; a membrane permeable to the substances/active ingredients to be delivered; a reservoir containing substances/active ingredients to be delivered, the reservoir being provided between the carrier layer and the membrane; and a removable film, wherein each of the carrier layer and the membrane comprise one or more electrodes such that the electrode(s) of the membrane serve(s) as counter electrode(s) to die electrode (the electrodes) of the carrier layer, is disclosed.

대표청구항 ▼

1. Transdermal delivery system (TDS) havinga carrier layer impermeable to a substance to be delivered,a membrane permeable to said substance to be delivered,a reservoir containing said substance to be delivered, the reservoir being provided between the carrier layer and the membrane, anda removable

1. Transdermal delivery system (TDS) havinga carrier layer impermeable to a substance to be delivered,a membrane permeable to said substance to be delivered,a reservoir containing said substance to be delivered, the reservoir being provided between the carrier layer and the membrane, anda removable film, whereineach of the carrier layer and the membrane comprises one or more electrodes such that the one or more electrodes of the membrane serve(s) as counter electrode(s) to the one or more electrodes of the carrier layer. 2. Delivery system according to claim 1 wherein the carrier layer comprises electrodes arranged in the form of one or more electrode networks on the carrier layer, each electrode network having a plurality of individual electrodes, and the membrane comprises electrodes arranged in the form of one or more electrode networks on the membrane as counter electrodes. 3. Delivery system according to claim 1 comprising(a) a battery;(b) a microchip that (i) is fixed to the carrier layer or (ii) is accommodated with the battery in an external housing and is connected to the electrodes of the carrier layer and of the membrane by means of flexible wiring systems, and(c) a reading and writing device for writing to the microchip. 4. Delivery system according to claim 1 comprising a carrier layer having a thickness in the range from 10 μm to 1000 μm. 5. Delivery system according to claim 1 wherein the reservoir is formed by a contact adhesive, a gel or an immobilised solution of the substance to be delivered. 6. Delivery system according to claim 1 wherein the one or more electrodes of the carrier layer and/or of the membrane has/have been applied by printing. 7. Delivery system according to claim 2 wherein there is a plurality of electrode networks, each electrode network is actuatable individually or a plurality of electrode networks are actuatable in groups and/or each individual electrode in a network is actuatable individually or a plurality of individual electrodes in a network are actuatable in groups. 8. Delivery system according to claim 1 wherein the membrane permeable to a substance is electrically conductive and is a metal lattice, or a polymer lattice on which a conductive layer has been vapour-deposited, or a perforated conductive layer. 9. Delivery system according to claim 1 wherein the membrane permeable to a substance is electrically conductive and has uninterrupted conductivity or has conductive areas that are separated by non-conductive areas, so that one or more networks of conductive areas are formed. 10. Delivery system according to claim 9 wherein each electrode of the carrier layer corresponds to a counter electrode with which it is uniquely associated. 11. Delivery system according to claim 3 wherein the microchip is securely bonded to the carrier layer. 12. Delivery system according to claim 3 wherein the microchip is a chip that is programmable according to a prescription. 13. Delivery system according to claim 3 wherein the battery is a button battery or sheet battery. 14. Delivery system according to claim 3 wherein the battery is provided in a pocket in the carrier layer. 15. Delivery system according to claim 1 wherein a layer comprising a pressure-sensitive contact adhesive for attaching the delivery system to skin and for improving contact with skin is applied to the side of the membrane remote from the reservoir.