An apparatus for blood oxygenation and delivery is provided. The apparatus advantageously comprises a liquid-to-liquid oxygenation assembly with a pressurizable chamber having inlets for a first gas-supersaturated fluid and a second fluid, such as blood. The inlets are advantageously positioned on t
An apparatus for blood oxygenation and delivery is provided. The apparatus advantageously comprises a liquid-to-liquid oxygenation assembly with a pressurizable chamber having inlets for a first gas-supersaturated fluid and a second fluid, such as blood. The inlets are advantageously positioned on the mixing chamber in such a way that the first fluid and the second fluid enter the mixing chamber normally to each other to promote mixing and liquid-to-liquid gas transfer. The apparatus also includes a delivery system coupled to the blood oxygenation assembly. The delivery system includes a generally tubular elongated member having a proximal end portion, a distal end portion, and a transition portion located between the proximal end portion and the distal end portion. The transitional portion is relatively flexible compared to the proximal end portion and is relatively stiff compared to the distal end portion. In another embodiment, the delivery system includes a generally tubular elongated member having a proximal end portion and a distal end portion with a plurality of holes.
대표청구항▼
1. A device for oxygenating blood and delivering the oxygenated blood to a patient, the device comprising:a blood pump assembly coupled to a supply of blood;a blood oxygenation assembly coupled to the blood pump assembly, the blood oxygenation assembly receiving the blood from the blood pump assembl
1. A device for oxygenating blood and delivering the oxygenated blood to a patient, the device comprising:a blood pump assembly coupled to a supply of blood;a blood oxygenation assembly coupled to the blood pump assembly, the blood oxygenation assembly receiving the blood from the blood pump assembly and oxygenating the blood, the blood oxygenation assembly comprising:a mixing chamber having a first inlet, a second inlet, and an outlet;a pump adapted to deliver the blood to the mixing chamber via the first inlet,wherein the first inlet is positioned on the mixing chamber in such a way that the blood enters the mixing chamber substantially tangential to a wall of the mixing chamber; anda gas-supersaturated fluid supply assembly adapted to deliver an oxygen-supersaturated fluid having a liquid phase supersaturated with oxygen to the mixing chamber via the second inlet to mix with the blood and form the oxygenated blood, wherein the oxygenated blood exits the mixing chamber through the outlet; anda delivery system coupled to the blood oxygenation assembly, the delivery system being adapted to deliver the oxygenated blood to a patient, the delivery system comprising:a generally tubular elongated member having a proximal end portion and a distal end portion, the proximal end portion being adapted to be inserted into the patient and the distal end portion being coupled to the blood oxygenation assembly, the member further having a first lumen for carrying the oxygenated blood generally extending from the proximal end portion to the distal end portion, and the member having a transition portion located between the proximal end portion and the distal end portion, the transitional portion being relatively flexible compared to the proximal end portion and being relatively stiff compared to the distal end portion. 2. The device, as set forth in claim 1, comprising at least one hole located in a peripheral wall of the member and extending to the first lumen. 3. The device, as set forth in claim 2, wherein the at least one hole is formed in the distal end portion of the member. 4. The device, as set forth in claim 1, comprising a plurality of holes located in a peripheral wall of the member and extending to the first lumen. 5. The device, as set forth in claim 4, wherein the plurality of holes are formed in the distal end portion of the member. 6. The device, as set forth in claim 4, wherein each of the plurality of holes comprise a throughway axis, each throughway axis being generally perpendicular to a longitudinal axis of the member and being circumferentially offset from each adjacent throughway axis. 7. The device, as set forth in claim 1, comprising a second lumen extending along at least a portion of the member. 8. The device, as set forth in claim 7, wherein the second lumen is sized and located to promote tracking of the member over a guidewire. 9. The device, as set forth in claim 1, comprising a radiopaque marker located on the member. 10. A device for oxygenating blood and delivering the oxygenated blood to a patient, the device comprising:a blood pump assembly coupled to a supply of blood;a blood oxygenation assembly coupled to the blood pump assembly, the blood oxygenation assembly receiving the blood from the blood pump assembly and oxygenating the blood, the blood oxygenation assembly comprising:a mixing chamber having a first inlet, a second inlet, and an outlet;a pump adapted to deliver the blood to the mixing chamber via the first inlet,wherein the first inlet is positioned on the mixing chamber in such a way that the blood enters the mixing chamber substantially tangential to a wall of die mixing chamber; anda gas-supersaturated fluid supply assembly adapted to deliver an oxygen-supersaturated fluid having a liquid phase supersaturated with oxygen to the mixing chamber via the second inter to mix with the blood and form the oxygenated blood,wherein the oxygenated blood exits the mixing chamber through the outlet; anda delivery system coupled to the blood oxygenation assembly, the delivery system being adapted to deliver the oxygenated blood to a patient, the delivery system comprising:a generally tubular elongated member having a proximal end portion, a distal end portion, and a longitudinal axis, the proximal end portion being adapted to be inserted into the patient and the distal end portion being coupled to the blood oxygenation assembly, the member further having a first lumen extending from the proximal end portion to the distal end portion for carrying the oxygenated blood, and having a plurality of holes formed in a peripheral wall of the member and extending to the first lumen, the plurality of holes being located in the distal end portion of the member, each of the plurality of holes having a throughway axis, each throughway axis being generally perpendicular to the longitudinal axis of the member and being circumferentially offset from each adjacent throughway axis. 11. The device, as set forth in claim 10, comprising a second lumen extending along at least a portion of the member. 12. The device, as set forth in claim 11, wherein the second lumen is sized and located to promote tracking of the member over a guidewire. 13. The device, as set forth in claim 10, comprising a radiopaque marker located on the member. 14. The device, as set forth in claim 10, wherein each throughway axis is circumferentially offset from each adjacent throughway axis by 90 degrees. 15. The device, as set forth in claim 10, wherein the member comprises a transition portion located between the proximal end portion and the distal end portion, the transitional portion being relatively flexible compared to the proximal end portion and being relatively stiff compared to the distal end portion. 16. The device, as set forth in claim 10, wherein the plurality of holes are spaced at least 0.5 inches from a distal end of the member. 17. The device, as set forth in claim 10, wherein the plurality of holes are sequentially spaced along the longitudinal axis. 18. The device, as set forth in claim 10, wherein the first lumen terminates in an open distal end of the member. 19. The device, as set forth in claim 10, wherein the first lumen terminates in a closed distal end of the member. 20. A device for oxygenating blood and delivering the oxygenated blood to a patient, the device comprising:a blood pump assembly coupled to a supply of blood;a blood oxygenation assembly coupled to the blood pump assembly, the blood oxygenation assembly receiving the blood from the blood pump assembly and oxygenating the blood, the blood oxygenation assembly comprising:a mixing chamber having a first inlet, a second inlet, and an outlet;a pump adapted to deliver the blood to the mixing chamber via the first inlet,wherein the first inlet is positioned on the mixing chamber in such a way that the blood enters the mixing chamber substantially tangential to a wall of the mixing chamber; anda gas-supersaturated fluid supply assembly adapted to deliver an oxygen-supersaturated fluid having a liquid phase supersaturated with oxygen to the mixing chamber via the second inlet to mix with the blood and form the oxygenated blood, wherein the oxygenated blood exits the mixing chamber through the outlet; anda delivery system coupled to the blood oxygenation assembly, the delivery system being adapted to deliver the oxygenated blood to a patient, the delivery system comprising:a generally tubular elongated member having a proximal end portion, a distal end portion, and a longitudinal axis, the proximal end portion being adapted to be inserted into the patient and the distal end portion being coupled to the blood oxygenation assembly, the member further having a first lumen extending from the proximal end portion to the distal end portion for carrying the oxygenated blood, and having a plurality of holes formed in a peripheral wall of the member and extending to the first lumen, the plurality of holes being located in the distal end portion of the member, each of the plurality of holes having a throughway axis, each throughway axis being generally perpendicular to the longitudinal axis of the member and being circumferentially offset from each adjacent throughway axis, the member further having a transition portion located between the proximal end portion and the distal end portion, the transitional portion being relatively flexible compared to the proximal end portion and being relatively stiff compared to the distal end portion. 21. The device of claim 1, 10 , or 20 , wherein the gas-supersaturated fluid supply assembly comprisesa fluid supply;a chamber having a first inlet, a second inlet, a third inlet and an outlet;an oxygen gas supply coupled to deliver oxygen to the first inlet of the chamber;a piston assembly coupled to receive fluid from the fluid supply and to deliver the fluid to the second inlet and the third inlet of the chamber;a nozzle coupled to the third inlet of the chamber, the nozzle delivering the fluid from the piston assembly to the chamber;a first valve coupled to the outlet of the chamber, the first valve being coupled to an actuator assembly to control delivery of oxygen-supersaturated fluid from the chamber, the outlet of the chamber being coupled to the second inlet of the blood oxygenation assembly to deliver the oxygen-supersaturated fluid into contact with the blood to form the oxygenated blood; anda second valve coupled to the second inlet, the second valve being coupled to an actuator assembly to control dilution during the creation of oxygen-supersaturated fluid within the chamber.
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Schiff ; Peter, Adapter for intra-aortic balloons and the like.
Spears James Richard (Bloomfield Hills MI) Crilly Richard James (Wondsor CAX), Apparatus and method of delivery of gas-supersaturated solutions to a delivery site.
Heldebrant Charles M. (Arcadia CA) Crowe Kim C. (Northridge CA) Groveman George R. (Clairmont CA) Davis ; Jr. Charles H. (Mission Viejo CA), Apparatus and process for oxygenation of liquid state dissolved oxygen-carrying formulation.
Montevecchi Franco M. (11 ; Via Malaspina Pioltello (MI) ITX 20096), Apparatus for concurrently oxgenating and pumping blood circulated extra-corporeally in cardiovascular systems.
Heldebrant Charles M. (Arcadia CA) Crowe Kim C. (Northridge CA) Groveman George R. (Clairmont CA) Davis ; Jr. Charles H. (Mission Viejo CA), Apparatus for oxygenation of liquid state dissolved oxygen-carrying formulation.
Vincent Divino, Jr. ; Seth A. Foerster ; James M. Gessert ; Robert A. Mest ; Paul J. Zalesky, Apparatus for the preparation and delivery of gas-enriched fluids.
Strauss Brian (Costa Mesa CA) Brown Jack (Santa Ana CA), Combined cardiotomy/venous/pleural drainage autotransfusion unit with filter and integral manometer and water seal.
Raible Donald A. (Santa Ana CA), Extracorporeal blood oxygenation system and method for providing hemoperfusion during transluminal balloon angioplasty p.
Habashi Nader M. (224 S. Caswell Rd. Charlotte NC 28204) Reynolds Howard N. (12 Severn River Rd. Severna Park MD 21146) Borg Ulf R. (44 Fox Run Way Arnold MD 21012), Extracorporeal lung assistance apparatus and process.
Lidorenko Nikolai S. (ulitsa Kibalchicha ; 2 ; korpus 1 ; kv. 217 Moscow SUX) Gorun Viktor T. (Streletskaya Ulitsa ; 14 ; korpus 1 ; kv. 11 Moscow SUX) Muchnik Grigory F. (Preobrazhenskaya ploschad ;, Gas-permeable membrane, and blood oxygenator based on gas-permeable membrane.
Panzani Ivo (Mirandola ITX) Ghelli Nicola (San Pietro in Casale ITX) Vescovini Pietro (Medolla ITX), Integrated unit for extracorporeal blood circuits.
Schmidtke Wolfgang (Paderborn DEX), Method and device for dissolving gas, especially carbon dioxide, in liquid fuel and for distributing the fuel in a super.
Divino ; Jr. Vincent ; Foerster Seth A. ; Gessert James M. ; Mest Robert A. ; Zalesky Paul J. ; Spears James Richard, Method for the preparation and delivery of gas-enriched fluids.
Wilson John R. (St. Anthony MN) Gaines ; Jr. William A. (Burnsville MN) Page Darrell P. (Coon Rapids MN) Harm William H. (Robinsdale MN), Method of culturing cells using highly gas saturated media.
Osterholm Jewell L. (Radnor Township ; Delaware County PA), Stroke treatment utilizing extravascular circulation of oxygenated synthetic nutrients to treat tissue hypoxic and ische.
Bonaventura Joseph (Beaufort NC) Bonaventura Celia (Beaufort NC) Van Ryzin Joseph C. (Kailua HI) Zenner Bruce D. (Beaufort NC) Anderson C. William (Durham NC), System for the extraction and utilization of oxygen from fluids.
Faivre Michel,FRX ; Martin Nathalie,FRX ; Boisdon Vincent,FRX, Unit for the treatment of water by ozonization, and a corresponding installation for the production of ozonized water.
Johnson Gilbert H. (2024 Hatch St. Eau Claire WI 54701) Straus Stephen R. (7195 Tara Ave. Las Vegas NV 89117) Giordano Joseph D. (2416 Enchantment Cr. Henderson NV 89014), Variable ratio blood-additive solution device and delivery system.
Johnson Gilbert H. (Las Vegas NV) Straus Stephen R. (Las Vegas NV) Giordano Joseph D. (Las Vegas NV), Variable ratio blood-additive solution device and delivery system.
Agranonik Robert Yakovlevich,RUX ; Pisklov Gennady Alexeevich,RUX, Wastewater treatment method, method of suspensions separation and method of saturation of liquid with gas.
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