초록 ▼

A fibrin mixture and dispenser assembly is provided for mixing a first protein component with sterile water to form a first protein solution and for dispensing the first protein solution. The first protein solution forms a biological adhesive when intermixed with a second protein solution. The secon

A fibrin mixture and dispenser assembly is provided for mixing a first protein component with sterile water to form a first protein solution and for dispensing the first protein solution. The first protein solution forms a biological adhesive when intermixed with a second protein solution. The second protein solution is preferably mixed and dispensed by a similar fibrin mixture and dispenser assembly. The two fibrin mixture and dispenser assemblies can be housed within a single housing. The assembly includes a piercer and a first tubular extension having grooves for providing fluid communication between a reservoir and a mixing chamber or a vial. The reservoir is also in fluid communication with a dispensing needle through a second tubular extension. The reservoir is configured to contain water which is introduced to the mixing chamber. The mixing chamber is configured to contain the first protein component. The water mixes with the first protein component within the mixing chamber to form the first protein solution. The solution is transferred to the reservoir and is dispensed via the dispensing needle. The first and second components are preferably fibrinogen and thrombin which intermix either prior to or on the application site to form a fibrin sealant.

대표청구항 ▼

1. An assembly for mixing a component of a biological adhesive with a liquid to form a solution and for dispensing the solution, the assembly comprising:a housing configured to receive a mixing chamber;a reservoir for holding a liquid, the reservoir being in fluid communication with said mixing cham

1. An assembly for mixing a component of a biological adhesive with a liquid to form a solution and for dispensing the solution, the assembly comprising:a housing configured to receive a mixing chamber;a reservoir for holding a liquid, the reservoir being in fluid communication with said mixing chamber via a first path and a dispensing needle via a second path;a first valve assembly having a first valve moveable from a first position to a second position to open fluid communication between said reservoir and said mixing chamber via said first path when said mixing chamber is received by said housing; anda second valve assembly having a second valve moveable from a closed position to an open position to open fluid communication between said reservoir and said dispensing needle via said second path, wherein the volumetric capacity of said mixing chamber remains constant during mixing and dispensing of said solution. 2. The assembly of claim 1, further comprising a flange adjacent to said reservoir for aiding to open fluid communication between said reservoir and said mixing chamber and for aiding to open fluid communication between said reservoir and said dispensing needle. 3. The assembly of claim 1, further comprising a piercing needle in longitudinal alignment with said first and second paths for piercing a sealable opening of said mixing chamber. 4. The assembly of claim 1, wherein said reservoir is compressible to force contents therein through said first path and into said mixing chamber when said first valve is in said second position and to force contents within said reservoir through said second path and through said dispensing needle when said first valve is in said first position. 5. The assembly of claim 1, wherein said mixing chamber is a vial having a sealable opening capable of being pierced by a piercer longitudinally aligned with said housing. 6. The assembly of claim 3, wherein said piercing needle engages a bottom inner surface of said mixing chamber when said housing receives said mixing chamber to cause said piercing needle to move distally to move said first valve from said first position to said second position. 7. The assembly of claim 3, wherein said piercing needle is biased to move proximally when said mixing chamber is removed from said housing to move said first valve from said second position to said first position. 8. The assembly of claim 1, wherein said reservoir includes an opening for adding said liquid therein. 9. The assembly of claim 1, wherein said solution is a thrombin solution or a fibrinogen solution, whereby said biological adhesive is a fibrin sealant. 10. An assembly for mixing a component of a biological adhesive with a liquid to form a solution and for dispensing the solution, the assembly comprising:a housing configured to receive a first reservoir configured to contain the component;an activator assembly operatively associated with a second reservoir configured to contain the liquid for transporting the liquid to the first reservoir via at least one conduit in fluid communication with said first reservoir and said second reservoir for mixing with the first component to form the solution, said liquid mixes with the first component in said first reservoir to form the solution, said solution is transported from said first reservoir to said second reservoir via said at least one conduit; anda dispensing assembly operatively associated with said second reservoir for transporting said solution from said second reservoir through a path leading to an opening for dispensing said solution, wherein the volumetric capacity of said first reservoir remains constant during mixing and dispensing of said solution. 11. The assembly of claim 10, wherein said dispensing assembly includes a dispensing needle in fluid communication with said path for dispensing said solution as a valve of said dispensing assembly is moved from a first position to a second position. 12. The assembly of claim 10, where in said second reservoir is compressible for forcing said liquid through said at least one conduit to transport said liquid to said reservoir. 13. The assembly of claim 10, wherein said second reservoir includes an opening for adding said liquid therein. 14. The assembly of claim 10, further comprising a flange adjacent to said second reservoir for aiding to transport the liquid to the first reservoir and for aiding to transport said solution from said second reservoir through said path. 15. The assembly of claim 10, wherein said first reservoir is a vial having a sealable opening capable of being pierced by a piercer longitudinally aligned with said housing. 16. The assembly of claim 10, wherein said activator assembly includes a valve movable from a first position to a second position for opening and closing said at least one conduit. 17. The assembly of claim 16, wherein said valve is configured to move from said first position to said second position when said first reservoir is received by said housing. 18. The assembly of claim 11, wherein said valve moves from a first position to a second position when said solution is forced through said path. 19. The assembly of claim 10, wherein said solution is a thrombin solution or a fibrinogen solution, whereby said biological adhesive is a fibrin sealant. 20. An assembly for mixing a first component of a biological adhesive with a first liquid to form a first solution, mixing a second component of the biological adhesive with a second liquid to form a second solution, and for dispensing the first and second solutions, the assembly comprising:a first housing configured to receive a first reservoir configured to contain the first component;a second housing configured to receive a second reservoir configured to contain the second component; anda third housing having an activator assembly operatively associated with a third reservoir configured to contain the first liquid for transporting the first liquid to the first reservoir via at least one conduit in fluid communication with said first reservoir and said third reservoir for mixing with the first component to form the first solution, said first liquid mixes with the first component in said first reservoir to form the first solution, said first solutions is transported from said first reservoir to said third reservoir via said at least one conduit, said activator assembly further operatively associated with a fourth reservoir configured to contain the second liquid for transporting the second liquid to the second reservoir via at least one conduit in fluid communication with said second reservoir and said fourth reservoir for mixing with the second component to form the second solution, said second liquid mixes with the second component in said second reservoir to form the second solution, said second solution is transported from said second reservoir to said fourth reservoir via said at least one conduit in fluid communication with said second reservoir and said fourth reservoir, said activator assembly further operatively associated with said third and fourth reservoirs for transporting said first and second solutions from said third and fourth reservoirs, respectively, through a first and a second path, respectively, leading to a first and a second opening, respectively, for dispensing said first and second solutions. 21. The assembly of claim 20, wherein said activator assembly includes a first and a second dispensing needle in fluid communication with said first and second paths, respectively, for dispensing said first and second solutions as a first and a second valve operatively associated with said first and second paths, respectively, are moved from a first position to a second position. 22. The assembly of claim 20, wherein said third and fourth reservoirs are compressible for forcing said first and second liquids therein through said at least one conduit in fluid communication with said first and third reservoirs and s aid at least one conduit in fluid communication with said second and fourth reservoirs to transport said first and second liquids to said first and second reservoirs, respectively. 23. The assembly of claim 20, wherein said third and fourth reservoirs include an opening for adding said first and second liquids therein. 24. The assembly of claim 20, further comprising a first flange operatively associated with said activator assembly for aiding to transport the first liquid to the first reservoir and for aiding to transport said first solution from said third reservoir through said first path, and a second flange operatively associated with said activator assembly for aiding to transport the second liquid to the second reservoir and for aiding to transport said second solution from said fourth reservoir through said second path. 25. The assembly of claim 20, wherein said first and second reservoirs are vials having a sealable opening capable of being pierced by a first and a second piercer, respectively, longitudinally aligned with said first and second housing. 26. The assembly of claim 20, further comprising a first valve movable from a first position to a second position for opening and closing said at least one conduit in fluid communication with said first and third reservoirs, and a second valve movable from a first position to a second position for opening and closing said at least one conduit in fluid communication with said second and fourth reservoirs. 27. The assembly of claim 26, wherein said first valve is configured to move from said first position to said second position when said first reservoir is received by said first housing and said second valve is configured to move from said first position to said second position when said second reservoir is received by said second housing. 28. The assembly of claim 21, wherein said first and second valve move from a first position to a second position when said first and second solutions are forced through said first and second paths, respectively. 29. The assembly of claim 20, wherein said first solution is a thrombin solution and said second solution is a fibrinogen solution, whereby said biological adhesive is a fibrin sealant.