IPC분류정보
국가/구분 |
United States(US) Patent
등록
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국제특허분류(IPC7판) |
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출원번호 |
US-0948987
(2001-09-07)
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발명자
/ 주소 |
- Shanley, John F.
- Eigler, Neal L.
- Edelman, Elazer R.
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출원인 / 주소 |
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대리인 / 주소 |
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인용정보 |
피인용 횟수 :
87 인용 특허 :
168 |
초록
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An expandable medical device having a plurality of elongated struts, the plurality of elongated struts being joined together by ductile hinges to form a substantially cylindrical device which is expandable from a cylinder having a first diameter to a cylinder having a second diameter. The plurality
An expandable medical device having a plurality of elongated struts, the plurality of elongated struts being joined together by ductile hinges to form a substantially cylindrical device which is expandable from a cylinder having a first diameter to a cylinder having a second diameter. The plurality of struts and ductile hinges are arranged to improve the spatial distribution of the struts which is particularly important when delivering beneficial agents with the struts. The improved strut arrangement expands to a substantially parallelogram shape for improved beneficial agent distribution to the surrounding tissue. A beneficial agent may be loaded into openings within the struts or coated onto the struts for delivery to the tissue.
대표청구항
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1. An expandable medical device comprising:a plurality of elongated struts, the plurality of elongated struts joined together to form a substantially cylindrical device which is expandable from a cylinder having a first diameter to a cylinder having a second diameter, wherein adjacent ones of the pl
1. An expandable medical device comprising:a plurality of elongated struts, the plurality of elongated struts joined together to form a substantially cylindrical device which is expandable from a cylinder having a first diameter to a cylinder having a second diameter, wherein adjacent ones of the plurality of elongated struts are substantially parallel when the cylinder is at the first diameter and the adjacent elongated struts form V-shapes when the cylinder is at the second diameter; anda plurality of pivots joining the plurality of struts together in the substantially cylindrical device, wherein only one pivot interconnects each two adjacent elongated struts and the pivots are each located offset from a line bisecting the V-shapes formed by the elongated struts when the cylinder is at the second diameter. 2. The device of claim 1, wherein the elongated struts are substantially L-shaped struts and the plurality of pivots connect an end of a short leg of the L-shaped strut to an end of a long leg of an adjacent L-shaped strut. 3. The device of claim 2, wherein an orientation of every other adjacent L-shaped strut is inverted with respect to the remaining L-shaped struts. 4. The device of claim 2, wherein the L-shaped struts are nested and the long legs of the L-shaped struts are substantially parallel when the cylinder is at the first diameter. 5. The device of claim 1, wherein the plurality of pivots are ductile hinges and wherein a width of the ductile hinges is smaller than a width of the elongated struts. 6. The device of claim 5, wherein the ductile hinges are tapered. 7. The device of claim 5, wherein the ductile hinges have a taper of about 0.1 to about 0.2 inches per inch. 8. The device of claim 1, wherein the plurality of pivots join radially adjacent struts together, and the pivots are each located offset from the line bisecting the V-shapes formed by the radially adjacent struts. 9. An expandable medical device comprising:a plurality of elongated struts, the plurality of elongated struts joined together to form a substantially cylindrical device which is expandable from a cylinder having a first diameter to a cylinder having a second diameter, wherein adjacent ones of the plurality of elongated struts are substantially parallel when the cylinder is at the first diameter and the adjacent elongated struts form V-shapes when the cylinder is at the second diameter; anda plurality of ductile hinges connecting the plurality of struts together in the substantially cylindrical device, wherein only one ductile hinge interconnects each two adjacent elongated struts and the ductile hinges are each located offset from a line bisecting the V-shapes formed by the elongated struts when the cylinder is at the second diameter, the ductile hinges having a hinge width which is smaller than a strut width such that as the device is expanded from the first diameter to the second diameter the ductile hinges experience plastic deformation while the struts are not plastically deformed. 10. The device of claim 9, wherein the elongated struts are substantially L-shaped struts and the plurality of ductile hinges connect an end of a short leg of the L-shaped strut to an end of a long leg of an adjacent L-shaped strut. 11. The device of claim 10, wherein an orientation of every other adjacent L-shaped strut is inverted with respect to the remaining L-shaped struts. 12. The device of claim 10, wherein the L-shaped struts are nested and the long legs of the L-shaped struts are substantially parallel when the cylinder is at the first diameter. 13. The device of claim 10, wherein the ductile hinges are tapered. 14. The device of claim 9, wherein the plurality of ductile hinges join radially adjacent struts together. 15. An expandable medical device comprising:a plurality of struts each having a long leg, a short leg connected to the long leg, and a connecting point, wherein the long leg has a length longer than a length of the short leg;a pluralit y of pivots joining the long leg of one strut to the short leg of an adjacent strut to form a substantially cylindrical device which is expandable from a cylinder having a first diameter to a cylinder having a second diameter, wherein as the substantially cylindrical device is expanded from the first diameter to the second diameter the pivots bend; anda plurality of bridging members connected to the connecting points of struts in one row and to the connecting points of struts in an adjacent row to form an expandable device configured such that a total length of the bridging members remains substantially constant during radial expansion. 16. The device of claim 15, wherein portions of the plurality of bridging members are configured to remain substantially parallel during expansion. 17. The device of claim 15, wherein the plurality of cylindrical members further comprise a beneficial agent for delivery to tissue. 18. The device of claim 15, wherein the expandable device is configured for radial expansion while an overall length of the device remains substantially constant. 19. The device of claim 15, wherein the total length of the bridging members is measured in an axial direction of the substantially cylindrical device. 20. An expandable medical device comprising:a plurality of elongated struts, the plurality of elongated struts joined together by pivoting connections to form a substantially cylindrical device which is expandable from a cylinder having a first diameter to a cylinder having a second diameter, wherein adjacent ones of the plurality of elongated struts are substantially parallel when the cylinder is at the first diameter and the adjacent elongated struts form a plurality of substantially parallelogram shapes when the cylinder is at the second diameter, the substantially parallelogram shapes having first and second opposite sides which are longer than third and fourth opposite sides. 21. The device of claim 20, wherein a beneficial agent is affixed in a plurality of openings formed in the plurality of elongated struts. 22. The device of claim 20, wherein a beneficial agent is coated on the plurality of struts. 23. The device of claim 20, wherein the plurality of elongated struts are arranged to form a plurality of chevrons having alternating orientations. 24. The device of claim 20, wherein the plurality of elongated struts are interconnected with bridging elements to form the substantially parallelogram shapes. 25. An expandable medical device for delivery of a beneficial agent, the device comprising:a plurality of elongated struts, the plurality of elongated struts joined together by pivoting connections to form a substantially cylindrical device which is expandable from a cylinder having a first diameter to a cylinder having a second diameter, wherein adjacent ones of the plurality of elongated struts are substantially parallel when the cylinder is at the first diameter and the adjacent elongated struts form a plurality of substantially parallelogram shapes when the cylinder is at the second diameter, the substantially parallelogram shapes having first and second opposite sides which are longer than third and fourth opposite sides;a beneficial agent affixed to the plurality of struts for delivery to tissue. 26. The device of claim 25, wherein the beneficial agent is affixed in a plurality of openings formed in the plurality of elongated struts. 27. The device of claim 25, wherein the beneficial agent is coated on the plurality of struts. 28. The device of claim 25, wherein the plurality of elongated struts are arranged to form a plurality of chevrons having alternating orientations. 29. The device of claim 25, wherein the plurality of elongated struts are interconnected with bridging elements to form the substantially parallelogram shapes. 30. The device of claim 25, wherein the expandable medical device has a coverage ratio of about 12% to about 20%. 31. The device of claim 25, wherein the beneficial agent is paclitaxel, or an analogue or derivative thereof. 32. The device of claim 25, wherein the beneficial agent is rapamycin, or an analogue or derivative thereof. 33. An expandable medical device comprising:a plurality of elongated struts;a plurality of ductile hinges connecting the plurality of struts together in a substantially cylindrical medical device which is expandable from a cylinder having a first diameter to a cylinder having a second diameter, wherein the plurality of ductile hinges are tapered with the taper oriented to achieve uniform strain along the ductile hinge during expansion of the cylinder from the first diameter to the second diameter. 34. The device of claim 33, wherein adjacent elongated struts form V-shapes when the cylinder is at the second diameter and wherein the plurality of ductile hinges are each tapered such that an end of the ductile hinge closer to the apex of the V-shape formed by the adjacent elongated struts has a width which is greater than a width of the ductile hinge at an opposite end. 35. The device of claim 33, wherein the taper of the ductile hinges is about 0.1 to about 0.2 inches per inch. 36. The device of claim 33, wherein the taper of the ductile hinges is about 0.2 inches per inch or less. 37. The device of claim 36, wherein the taper is substantially constant along a length of the ductile hinges. 38. The device of claim 33, wherein the taper is a non-linear taper bounded by two curves. 39. The device of claim 33, wherein the ductile hinge has a largest cross sectional area at a point where stresses in the beam are greatest during expansion from the first diameter to the second diameter. 40. The device of claim 33, wherein the taper extends along substantially an entire length of the ductile hinges.
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