Adhesively applied external nasal strips and dilators containing medications and fragrances
IPC분류정보
국가/구분
United States(US) Patent
등록
국제특허분류(IPC7판)
A62B-029/00
A61M-029/00
A61B-017/00
출원번호
US-0859319
(2001-05-17)
발명자
/ 주소
Cronk, Peter J.
Cronk, Kristen
대리인 / 주소
Duane Morris LLP
인용정보
피인용 횟수 :
67인용 특허 :
104
초록▼
Nasal dilators and strips, methods of their manufacture, and methods for improving the breathing of individuals are provided. The strips and dilators include an elongated substrate, with or without a dilating component or portion, having top and bottom surfaces and a pressure-sensitive adhesive disp
Nasal dilators and strips, methods of their manufacture, and methods for improving the breathing of individuals are provided. The strips and dilators include an elongated substrate, with or without a dilating component or portion, having top and bottom surfaces and a pressure-sensitive adhesive disposed on the bottom surface. The dilator is designed to provide a gentle expanding force to the nasal wall tissue when the dilator is adhesively attached to the nose. This invention further includes a cosmetic fragrance, an aromatic medication and/or transdermal medication disposed on the strips or dilators. In order to improve the shelf-life and in-use olfactory effectiveness of such products, fragrance delivery mechanisms are used. Separation of volatile oils and adhesives are also provided to minimize adhesive residue.
대표청구항▼
1. A nasal dilator adapted for adhesive application to an external nasal wall tissue of a wearer, comprising:an elongated flexible substrate sized to comfortably fit across a bridge portion of the wearer's nose;a resilient member joined to said flexible substrate to provide for a gentle expanding fo
1. A nasal dilator adapted for adhesive application to an external nasal wall tissue of a wearer, comprising:an elongated flexible substrate sized to comfortably fit across a bridge portion of the wearer's nose;a resilient member joined to said flexible substrate to provide for a gentle expanding force upon the external nasal wall tissue when said elongated flexible substrate and resilient membrane are adhered thereon;a pressure sensitive adhesive layer disposed on a first surface portion of said flexible substrate, said resilient member, or both, said first surface portion or portions facing the external wall tissue of said wearer; andan aromatic substance positioned on a second surface portion of said flexible substrate, said resilient member, or both, said second surface portion or portions facing away from said external wall tissue, said aromatic substance being inhaleable through the wearer's nose during breathing when said dilator is worn. 2. The nasal dilator of claim 1, wherein said aromatic substance comprises a medication in a dosage of at least about 0.1 mg per cm 2 of said wearer's skin. 3. The nasal dilator of claim 1, wherein said aromatic substance is substantially body activated by body heat, pH, or sweat. 4. The nasal dilator of claim 3, wherein said extended release means comprises: a fixative, gel, starch, microcapsule, fragrance carrier, pH-sensitive compound, waxy substance, polymer, cyclodextrine, cellulose, homologues, combinations, derivatives or chemical variations thereof. 5. The nasal dilator of claim 1, wherein said aromatic substance comprises a fragrance oil. 6. The nasal dilator of claim 1, wherein said aromatic substance comprises:camphor, eucalyptus oil, peppermint oil, menthol, methylsalicylate, bornyl acetate, lavender oil, citrus, an antihistamine, a decongestant, an anti-inflammatory agent, a vitamin, an analgesic, anesthetic, antipruritic, homologues, derivatives, chemical variations or combinations thereof. 7. The nasal dilator of claim 1, wherein said resilient member comprises at least one polymer spring strip for providing said gentle expanding force to said external nasal wall tissue when said nasal dilator is adhesively attached to a wearer's nose. 8. The nasal dilator of claim 7, wherein said elongated resilient flexible substrate comprises a woven layer, non-woven layer, scrim, composite, sheet material, or a combination thereof. 9. The nasal dilator of claim 1, wherein said aromatic substance comprises a dual fragrance delivery system for minimizing olfactory saturation. 10. The nasal dilator of claim 1, wherein said aromatic substance comprises at least two fragrance notes. 11. A method of manufacturing a nasal dilator, comprising:(a) providing a flexible substrate material and a resilient member(b) joining said flexible substrate material to said resilient member to form an integral web;(c) applying an adhesive layer to a first surface of said integral web which is intended to face an external nasal wall tissue of a wearer;(e) applying an aromatic substance to a second surface of said integral web opposing said first surface; and(d) cutting said integral web to form a final periphery of a nasal dilator suitable for adhesive attachment to an external nasal wall tissue of a wearer, so as to deliver said aromatic substance through inhalation by said wearer while providing a gentle expanding force to said external nasal wall tissue. 12. The method of claim 11, wherein said applying step further comprises providing a fragrance delivery system for said aromatic substance. 13. The method of claim 12, wherein said fragrance delivery system comprises: a fixative, gel, starch, microcapsule, fragrance carrier, pH-sensitive compound, waxy substance, polymer, cyclodextrine, cellulose, combinations, derivatives or chemical variations thereof. 14. The method of claim 11, wherein said aromatic substance comprises: camphor, eucalyptus oil, peppermint oil, menthol, methylsalicylate, bornyl acet ate, lavender oil, citrus, an antihistamine, a decongestant, an anti-inflammatory agent, a vitamin, an analgesic, anesthetic, antipruritic, homologues, derivatives, chemical variations or combinations thereof. 15. The method of claim 11, wherein said cutting step (e) comprises die-cutting to form a final periphery of the dilator. 16. The method of claim 11, wherein said joining step (b) comprises combining said flexible substrate material and said resilient member by melt bonding, adhesive bonding, ultrasonic bonding or a combination thereof. 17. The method of claim 11, wherein said joining step (b) comprises adhesively joining said flexible substrate material and said resilient member as they are fed into an overlapping position in a die or roller. 18. The method of claim 12, wherein said fragrance delivery system comprises at least two fragrance delivery mechanisms for minimizing olfactory saturation in said patient. 19. The method of claim 11, wherein said aromatic substance is separated from said adhesive layer. 20. The method of claim 11, further comprising applying a transdermal medication to said web. 21. A nasal dilator adapted for adhesive application to an external nasal wall tissue of a wearer, comprising:an elongated flexible substrate sized to comfortably fit across a bridge portion of the wearer's nose;a resilient member joined to said flexible substrate to provide for a gentle expanding force upon the external nasal wall tissue when said elongated flexible substrate and resilient membrane are adhered thereon;a pressure sensitive adhesive layer disposed on a surface of said dilator for adhesive attachment to said external nasal wall tissue; andan aromatic substance positioned on a portion of said flexible substrate, said resilient member, or both, so that said aromatic substance is inhaleable through the wearer's nose during breathing when said dilator is worn, said aromatic substance comprising at least one cooling agent. 22. The nasal dilator of claim 21, wherein said cooling agent comprises menthol, menthol based or a cyclic carboximides, and menthol-based or acyclic ketals (acetals), or a combination thereof. 23. The nasal dilator of claim 21 further comprising extended release means for extended release of said aromatic substance. 24. A nasal dilator adapted for adhesive application to an external nasal wall tissue of a wearer, comprising:an elongated flexible substrate sized to comfortably fit across a bridge portion of the wearer's nose;a resilient member joined to said flexible substrate to provide for a gentle expanding force upon the external nasal wall tissue when said elongated flexible substrate and resilient membrane are adhered thereon;a pressure sensitive adhesive layer disposed on a nasal wall tissue-facing surface of said dilator for adhesive attachment to said external nasal wall tissue; anda fragrance containing a volatile oil positioned on a portion of said flexible member, said resilient member, or both, which faces away from said nasal wall tissue so that said fragrance is substantially only consumed by the wearer via inhalation through the wearer's nose during breathing when said dilator is worn. 25. The nasal dilator of claim 24, wherein said fragrance contains a cooling agent for effecting nasal nerve endings responsible for hot and cold sensations.
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