초록

The present invention relates to soft capsules comprising(a) polymers prepared by polymerization of vinyl esters in the presence of polyethers(b) where appropriate structure-improving auxiliaries and(c) where appropriate other conventional constituents,the use and production thereof.

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1. A soft capsule shell comprising(a) from 10 to 100% of polymers prepared by polymerization of vinyl esters in the presence of polyethers(b) from 0 to 80% of structure-improving auxiliaries and(c) from 0 to 30% of other constituents selected from the group consisting of fillers, release agents, flo

1. A soft capsule shell comprising(a) from 10 to 100% of polymers prepared by polymerization of vinyl esters in the presence of polyethers(b) from 0 to 80% of structure-improving auxiliaries and(c) from 0 to 30% of other constituents selected from the group consisting of fillers, release agents, flow aids, stabilizers, water-soluble or water-insoluble dyes, flavorings and sweeteners,and wherein the polymers (a) are obtained by free-radical polymerization ofa) at least one vinyl ester of C 1 -C 24 -carboxylic acids in the presence ofb) polyether-containing compounds of the general formula Iin which the variables have, independently of one another, the following meaning:R 1 hydrogen, C 1 -C 24 -alkyl, R 6 —C(═O)—, R 6 —NH—C(═O)—, polyalcohol residue;R 5 hydrogen, C 1 -C 24 -alkyl, R 6 —C(═O)—, R 6 —NH—C(═O)—;R 2 to R 4 —(CH 2 ) 2 —, —(CH 2 ) 3 —, —(CH 2 ) 4 —, —CH 2 —CH(R 6 )—, —CH 2 —CHOR 7 —CH 2 —;R 6 C 1 -C 24 -alkyl;R 7 hydrogen, C 1 -C 24 -alkyl, R 6 —C(═O)—, R 6 —NH—C(═O)—;A —C(═O)—O, —C(═O)—B—C(═O)—O, —C(═O)—NH—B—NH—C(═O)—O;B —(CH 2 ) t —, arylene, optionally substituted;n 1 to 1000;s 0 to 1000;t 1 to 12;u 1 to 5000;v 0 to 5000;w 0 to 5000;x 0 to 5000;y 0 to 5000;z 0 to 5000; andc) from 0 to 50% of one or more other copolymerizable monomers and subsequent at least partial hydrolysis of the ester functions in the original monomers a). 2. A soft capsule shell as claimed in claim 1, wherein the polyether-containing compounds of formula I have a number average molecular weight of from 300 to 100000, and the variables have, independently of one another, the following meaning:R 1 hydrogen, C 1 -C 12 -alkyl, R 6 —C(═O)—, R 6 —NH—C(═O)—, polyalcohol residue;R 5 hydrogen, C 1 -C 12 -alkyl, R 6 —C(═O)—, R 6 —NH—C(═O)—;R 2 to R 4 —(CH 2 ) 2 —, —(CH 2 ) 3 —, —(CH 2 ) 4 —, —CH 2 —CH(R 6 )—, —CH 2 —CHOR 7 —CH 2 —;R 6 C 1 -C 12 -alkyl;R 7 hydrogen, C 1 -C 12 -alkyl, R 6 —C(═O)—, R 6 —NH—C(═O)—;n 1 to 8;s 0;u 2 to 2000;v 0 to 2000;w 0 to 2000. 3. A soft capsule shell as claimed in claim 1, wherein the polyether-containing compounds of formula I have a number average molecular weight of from 500 to 50000, and the variables have, independently of one another, the following meaning:R 1 hydrogen, C 1 -C 6 -alkyl, R 6 —C(O)—, R 6 —NH—C(═O)—;R 5 hydrogen, C 1 -C 6 -alkyl, R 6 —C(O)—, R 6 —NH—C(═O)—;R 2 to R 4 —(CH 2 ) 2 —, —(CH 2 ) 3 —, —(CH 2 ) 4 —, —CH 2 —CH(R 6 )—, —CH 2 —CHOR 7 —CH 2 —;R 6 C 1 -C 6 -alkyl;R 7 hydrogen, C 1 -C 6 -alkyl, R 6 —C(═O)—, R 6 —NH—C(═O)—;n 1;s 0;u 5 to 1000;v 0 to 1000;w 0 to 1000. 4. A soft capsule shell as claimed in claim 1, wherein the polymers (a) are obtained by free-radical polymerization ofa) at least one vinyl ester of C 1 -C 24 -carboxylic acids in the presence ofb) polyether-containing compounds andc) one or more other copolymerizable monomersand subsequent at least partial hydrolysis of the ester functions in the original monomers a), wherein the polyether-containing compounds b) have been prepared by polymerization of ethylenically unsaturated alkylene oxide-containing monomers, alone o r together with other copolymerizable monomers. 5. A soft capsule shell as claimed in claim 4, wherein the polyether-containing compounds b) have been prepared by polymerization of polyalkylene oxide vinyl ethers, alone or together with other copolymerizable monomers. 6. A soft capsule shell as claimed in claim 4, wherein the polyether-containing compounds b) have been prepared by polymerization of polyalkylene oxide (meth)acrylates, alone or together with other copolymerizable monomers. 7. A soft capsule shell as claimed in claim 1, wherein said other copolymerizable monomers c) are selected from the group consisting of:acrylic acid, methacrylic acid, maleic acid, fumaric acid, crotonic acid, maleic anhydride and its monoesters, methyl acrylate, methyl methacrylate, ethyl acrylate, ethyl methacrylate, n-butyl acrylate, n-butyl methacrylate, t-butyl acrylate, t-butyl methacrylate, isobutyl acrylate, isobutyl methacrylate, 2-ethylhexyl acrylate, stearyl acrylate, stearyl methacrylate, N-t-butylacrylamide, N-octylacrylamide, 2-hydroxyethyl acrylate, hydroxypropyl acrylates, 2-hydroxyethyl methacrylate, hydroxypropyl methacrylates, alkylene glycol (meth)acrylates, styrene, unsaturated sulfonic acids. 8. A soft capsule shell as claimed in claim 1, wherein the amounts of a), b) and c) area) 10 to 98% by weightb) 2 to 90% by weightc) 0 to 50% by weight. 9. A soft capsule shell as claimed in claim 1, wherein the amounts of a), b) and c) area) 50 to 97% by weightb) 3 to 50% by weightc) 0 to 20% by weight. 10. A soft capsule shell as claimed in claim 1, wherein the amounts of a), b) and c) area) 65 to 97% by weightb) 3 to 35% by weightc) 0 to 20% by weight. 11. A soft capsule shell as claimed in claim 1, wherein the resulting polymers are subsequently crosslinked. 12. A soft capsule shell as claimed in claim 11, wherein the resulting polymers are subsequently crosslinked by reaction with one or more compounds selected from the group consisting of dialdehydes, diketones, dicarboxylic acids, boric acid, boric acid salts, and salts of multiply charged cations. 13. A soft capsule shell as claimed in claim 1, wherein the structure-improving auxiliaries (b) employed are compounds from the following classes:a) polymers with a molecular weight of more than 50000,b) substances leading to crosslinking of the polymer chains of the polymers,c) and, optionally, substances which lead to crosslinking of the polymer chains of the structure-improving auxiliaries. 14. A soft capsule shell as claimed in claim 1, wherein the structure-improving auxiliaries employed are polymers selected from the group consisting of the following classes of substances: polyamino acids, polysaccharides and synthetic polymers. 15. A soft capsule shell as claimed in claim 1, which consists of from 10 to 100% by weight of polymers of vinyl esters on polyether, from 0 to 80% of structure-improving auxilaries and from 0 to 30% of said other constituents. 16. A soft capsule shell as claimed in claim 1, obtained by a process selected from the groups consisting of the rotary die process, Accogel process, Norton process, drop or blow process or the Colton-Upjohn process. 17. A soft capsule shell as claimed in claim 1, which encapsulates one or more active pharmaceutical ingredients, vitamins, carotenoids, minerals, trace elements, food supplements, cosmetic active ingredients, crop protection agents, bath additives, perfume, flavoring, cleaners or detergents. 18. A soft capsule shell as claimed in claim 1, wherein the shell comprises from 20 to 80% of a polymer resistant to gastric fluid. 19. A soft capsule shell as claimed in claim 1, wherein resistance to gastric fluid is achieved by applying after production a coating resistant to gastric fluid by pharmaceutical coating processes. 20. A soft capsule shell as claimed in claim 17 which encapsulates one or more pharmaceutical ingredients. 21. A soft capsule shell as claimed in claim 17 which encapsulates one or more cosmetic active ingredients, crop protection agents, for cleaners or food supplements. 22. A soft capsule shell as claimed in claim 14, wherein said polyamino acids are selected from the group consisting of gelatin, zein, soybean protein and derivatives thereof. 23. A soft capsule shell as claimed in claim 14, wherein said polysaccharides are selected from the group consisting of starch, degraded starch, maltodextrins, carboxymethyl starch, cellulose, hydroxypropylmethylcellulose, hydroxypropylcellulose, hydroxyethylcellulose, methylcellulose, carboxymethylcellulose, ethylcellulose, cellulose acetate, cellulose acetate phthalate, hydroxypropylcellulose acetate phthalate, hydroxypropylcellulose acetate succinate, hemicellulose, galactomannans, pectins, alginates, carrageenans, xanthan, gellan, dextran, curdlan, pullulan, gum arabic, chitin, and derivatives thereof. 24. A soft capsule shell as claimed in claim 14, wherein said synthetic polymers are selected from the group consisting of polyacrylic acid, polymethacrylic acid, copolymers of acrylic esters and methacrylic esters, polyvinyl alcohols, polyvinyl acetate, polyethylene glycols, polyoxyethylene/polyoxypropylene block copolymers, polyvinylpyrrolidones and derivatives thereof. 25. A soft capsule shell as claimed in claim 1, wherein the amounts of (a), (b) and (c) are:(a) 20 to 98% by weight;(b) 1 to 50% by weight; and(c) 0.1 to 30% by weight.