Contrast agent comprising low density microspheres
원문보기
IPC분류정보
국가/구분
United States(US) Patent
등록
국제특허분류(IPC7판)
A61B-008/00
A61K-009/50
B01F-017/00
출원번호
US-0280844
(2002-10-25)
발명자
/ 주소
Unger, Evan C.
출원인 / 주소
Bristol-Myers Squibb Medical Imaging, Inc.
대리인 / 주소
Volles Warren K.
인용정보
피인용 횟수 :
39인용 특허 :
221
초록▼
Low density microspheres, methods for preparing same, and use of same as contrast agents are described. The microspheres have a void having a volume that comprises at least about 75% of the total volume of the microspheres, and which contains a gas or the vapor of a volatile liquid selected from the
Low density microspheres, methods for preparing same, and use of same as contrast agents are described. The microspheres have a void having a volume that comprises at least about 75% of the total volume of the microspheres, and which contains a gas or the vapor of a volatile liquid selected from the group consisting of aliphatic hydrocarbons, chlorofluorocarbons, tetraalkyl silanes and perfluorocarbons.
대표청구항▼
1. A contrast agent comprising an aqueous suspension of low density microspheres, said low density microspheres having a void containing a gas or the vapor of a volatile liquid selected from the group consisting of aliphatic hydrocarbons, chlorofluorocarbons, tetraalkyl silanes and perfluorocarbons,
1. A contrast agent comprising an aqueous suspension of low density microspheres, said low density microspheres having a void containing a gas or the vapor of a volatile liquid selected from the group consisting of aliphatic hydrocarbons, chlorofluorocarbons, tetraalkyl silanes and perfluorocarbons, wherein said void has a volume that comprises at least about 75% of the volume of the microsphere and wherein said contrast agent is suitable for administration to a patient either orally, rectally, or by injection. 2. A contrast agent according to claim 1, wherein said microspheres comprise a biocompatible polymer. 3. A contrast agent according to claim 2 wherein said polymer comprises a synthetic polymer or copolymer prepared from the group of monomers consisting of acrylic acid, methacrylic acid, ethyleneimine, crotonic acid, acrylamide, ethyl acrylate, methyl methacrylate, 2-hydroxyethyl methacrylate, lactic acid, glycolic acid, ε-caprolactone, acrolein, cyanoacrylate, bisphenol A, epichiorhydrin, hydroxyalkylacrylates, siloxane, dimethylsiloxane, ethylene oxide, ethylene glycol, hydroxyalkyl-methacrylates, N-substituted acrylamides, N-substituted methacrylamides, N-vinyl-2-pyrrolidone, 2,4-pentadiene-1-ol, vinyl acetate, acrylonitrile, styrene, p-amino-styrene, p-amino-benzyl-styrene, sodium styrene sulfonate, sodium 2-sulfoxyethyl methacrylate, vinyl pyridine, aminoethyl methacrylates, 2-methacryloyloxy-trimethylammonium chloride, N,N′-methylenebisacrylamide, ethylene glycol dimethacrylates, 2,2′-(p-phenylenedioxy)-diethyl dimethacrylate, divinylbenzene, triallylamine, and methylenebis-(4-phenyl-isocyanate). 4. A contrast agent according to claim 3 wherein said microspheres comprise synthetic polymers or copolymers prepared from the group of monomers consisting of acrylic acid, methacrylic acid, ethyleneimine, crotonic acid, acrylamide, ethyl acrylate, methyl methacrylate, 2-hydroxyethyl methacrylate, lactic acid, glycolic acid, ε-caprolactone, acrolein, cyanoacrylate, bisphenol A, epichiorhydrin, hydroxyalkylacrylates, siloxane, dimethylsiloxane, ethylene oxide, ethylene glycol, hydroxyalkyl-methacrylates, N-substituted acrylamides, N-substituted methacrylamides, N-vinyl-2-pyrrolidone, 2,4-pentadiene-1-ol, vinyl acetate, acrylonitrile, styrene, p-amino-styrene, p-amino-benzyl-styrene, sodium styrene sulfonate, sodium 2-sulfoxyethylmethacrylate, vinyl pyridine, aminoethyl methacrylates, and 2-methacryloyloxy-trimethylammonium chloride. 5. A contrast agent according to claim 1 wherein said microspheres comprise biocompatible synthetic polymers or copolymers selected from the group consisting of polyacrylic acid, polyethyleneimine, polymethacrylic acid, polymethylmethacrylate, polysiloxane, polydimethylsiloxane, polylactic acid, poly(ε-caprolactone), epoxy resin, poly(ethylene oxide), poly(ethylene glycol), polyamide, polyvinylidene-polyacrylonitrile, polyvinylidene-poly-acrylonitrile-polymethylmethacrylate, and polystyrene-polyacrylonitrile. 6. A contrast agent according to claim 1 wherein said microspheres are prepared by a heat expansion process. 7. A contrast agent according to claim 1 wherein said microspheres are gas-filled. 8. A contrast agent according to claim 7 wherein said gas in said gas-filled microspheres is selected from the group consisting of carbon dioxide, oxygen, nitrogen, xenon, argon, neon, and helium. 9. A contrast agent according to claim 1 wherein said microspheres are filled with the vapor of a perfluorocarbon. 10. A contrast agent according to claim 9 where said perfluorocarbon has between 1 and about 9 carbon atoms and between 4 and about 20 fluorine atoms. 11. A contrast agent according to claim 10 wherein said perfluorocarbon has between 1 and 4 carbon atoms and between 4 and 10 fluorine atoms. 12. A contrast agent according to claim 10 wherein said perfluorocarbon has between 4 and, about 9 carbon atoms and between 10 and about 20 fluorine atoms. 13. A contrast age nt according to claim 10 wherein said perfluorocarbon is C 4 F 10 . 14. A contrast agent according to claim 1, further comprising a thickening or suspending agent.
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이 특허에 인용된 특허 (221)
Moore Dennis A. (Ferguson MO) Adams Max D. (St. Charles MO) Cacheris William P. (Florissant MO) White David H. (Ballwin MO) Periasamy Muthunadar P. (Chesterfield MO) Rajagopalan Raghavan (Maryland He, 19F magnetic resonance imaging agents which include a nitroxide moiety.
Nicolau Yves-Claude (La Chapelle FRX) Le Pape Alain (Langeais FRX) Barot-Ciorbaru Rita (Fontenay-Aux-Roses FRX), Aerosol composition for in vivo imaging.
Dory Jacques (91 ; rue des Molveaux 77450 Coupvray-Esblay FRX), Apparatus for examining and localizing tumors using ultra sounds, comprising a device for localized hyperthermia treatme.
Heldebrant Charles M. (Arcadia CA) Crowe Kim C. (Northridge CA) Groveman George R. (Clairmont CA) Davis ; Jr. Charles H. (Mission Viejo CA), Apparatus for oxygenation of liquid state dissolved oxygen-carrying formulation.
Long ; Jr. David M. (San Diego CA), Biocompatible stable fluorocarbon emulsions for contrast enhancement and oxygen transport comprising 40-125% wt./volume.
Long ; Jr. David M. (El Cajon CA), Biocompatible, stable and concentrated fluorocarbon emulsions for contrast enhancement and oxygen transport in internal.
Jay Michael J. (Lexington KY) Ryo U. Yun (Lexington KY), Biodegradable, low biological toxicity radiographic contrast medium and method of x-ray imaging.
Hilmann Juergen (Berlin DEX) Hoffmann Rolf-Ruediger (Berlin DEX) Muetzel Wolfgang (Berlin DEX) Zimmermann Ingfried (Berlin DEX), Carrier liquid solutions for the production of gas microbubbles, preparation thereof, and use thereof as contrast medium.
Melber George E. (Buffalo NY) Oswald William A. (Darien IL) Wolinski Leon E. (Buffalo NY), Composition and process for drying and expanding microspheres.
Grinstaff Mark W. (Pasadena CA) Soon-Shiong Patrick (Los Angeles CA) Wong Michael (Champaign IL) Sandford Paul A. (Los Angeles CA) Suslick Kenneth S. (Champaign IL) Desai Neil P. (Los Angeles CA), Composition useful for in vivo delivery of biologics and methods employing same.
Higgins William A. (Gates Mills OH) Bretz John (Parma OH), Compositions containing basic metal salts and/or non-Newtonian colloidal disperse systems and vinyl aromatic containing.
Cerny David (Chula Vista CA) Mills Gary J. (San Diego CA) Westkaemper Peter J. (San Diego CA), Continuous sonication method for preparing protein encapsulated microbubbles.
Schneider David R. (Birmingham MI) Bis Kostaki G. (Troy MI), Contras agent having an imaging agent coupled to viable granulocytes for use in magnetic resonance imaging of abscess an.
Klaveness Jo (Olso NOX) Rongved Pl (Hellvik NOX) Stubberud Lars (Sodertalje SEX), Contrast agents, consisting of galactose particles and an amphilic carboxylic acid.
Lohrmann Rolf (La Jolla CA) Widder Kenneth J. (Rancho Santa Fe CA) Krishnan Ashwin M. (San Diego CA) Hong Dung K. (San Diego CA) Meng Jialun (San Diego CA), Emulsions as contrast agents and method of use.
Cacheris William P. (Florissant MO) Kaufman Robert J. (University City MO) Richard Thomas J. (University City MO) Grabiak Raymond C. (Maryland Heights MO), Emulsions of paramagnetic contrast agents for magnetic resonance imaging (MRI)..
Rubens Louis C. (Midland MI) Alexander Willard E. (Midland MI), Expandable synthetic resinous thermoplastic particles, method for the preparation thereof and the application therefor.
Cullis Pieter R. (Vancouver CAX) Hope Michael J. (Vancouver CAX) Bally Marcel B. (Vancouver CAX), Extrusion technique for producing unilamellar vesicles.
Unger Evan C. (13365 E. Camino La Cebadilla Tucson AZ 85749) Wu Guanli (2602 W. Aiden St. Tucson AZ 85745), Gas filled liposomes and their use as ultrasonic contrast agents.
Yan Feng (Carouge CHX) Schneider Michel (Troinex CHX) Brochot Jean (Feigeres FRX), Gas mixtures useful as ultrasound contrast media, contrast agents containing the media and method.
Cohen Smadar (Petach-Tickva MA ILX) Andrianov Alexander K. (Belmont MA) Wheatley Margaret (Media PA) Allcock Harry R. (State College PA) Langer Robert S. (Newton MA), Gas-filled polymeric microbubbles for ultrasound imaging.
Kaufman Robert J. ; Richard Thomas J. ; Moore George G. I. ; Flynn Richard M., Highly fluorinated, chloro-substituted organic compound-containing emulsions and methods of making and using them.
Kaufman Robert J. (University City MO) Richard Thomas J. (University City MO), Highly fluorinated, chloro-substituted organic compound-containing emulsions and methods of using them.
Baldeschwieler John D. (Pasadena CA) Gamble Ronald C. (Pasadena CA) Mauk Marcia R. (Vancouver NJ CAX) Shen Tsung-Ying (Westfield NJ) Ponpipom Mitree M. (Branchburg NJ), Lipid vesicles bearing carbohydrate surfaces as lymphatic directed vehicles for therapeutic and diagnostic substances.
Axelsson Bengt I. (Genarp SEX) Brattsand Ralph L. (Lund SEX) Dahlbck Carl M. O. (Lund SEX) Kllstrm Leif A. (Sdra Sandby SEX) Trofast Jan W. (Lund SEX), Liposomes containing steroid esters.
Woodle Martin C. (Menlo Park CA) Martin Francis J. (San Francisco CA) Yau-Young Annie (Los Altos CA) Redemann Carl T. (Walnut Creek CA), Liposomes with enhanced circulation time.
Schneider Michel (Troinex CHX) Yan Feng (Geneva CHX) Grenier ; deceased Pascal (late of Ambilly FRX by Nadine Garcel ; legal heir ) Puginier Jerome (Le Chable-Beaumont FRX) Barrau Marie-Bernadette (G, Long-lasting aqueous dispersions or suspensions of pressure-resistant gas-filled microvesicles and methods for the prepa.
Cline Harvey E. (Schenectady NY) Ettinger Robert H. (Schenectady NY) Rohling Kenneth W. (Burnt Hills NY) Watkins Ronald D. (Niskayuna NY), Magnetic resonance guided focussed ultrasound surgery.
Albert Mitchell S. (Shoreham NY) Balamore Dilip (Shoreham NY) Cates ; Jr. Gordon D. (Skillman NJ) Driehuys Bastiaan (Bristol PA) Happer William (Princeton NJ) Saam Brian (Princeton NJ) Wishnia Arnold, Magnetic resonance imaging using hyperpolarized noble gases.
Desai Neil P. (Los Angeles CA) Soon-Shiong Patrick (Los Angeles CA) Sandford Paul A. (Los Angeles CA) Grinstaff Mark W. (Pasadena CA) Suslick Kenneth S. (Champaign IL), Magnetic resonance imaging with fluorocarbons encapsulated in a cross-linked polymeric shell.
Baldeschwieler John D. (Pasadena CA) Gamble Ronald C. (Pasadena CA) Mauk Marcia R. (Vancouver CAX), Means of preparation and applications of liposomes containing high concentrations of entrapped ionic species.
Radhakrishnan Ramachandran (Fremont CA) Mihalko Paul J. (Fremont CA) Abra Robert M. (San Francisco CA), Method and apparatus for administering dehydrated liposomes by inhalation.
Pierschbacher Michael D. (San Diego CA) Cheng Soan (San Diego CA) Craig William S. (San Diego CA) Tschopp Juerg F. (San Diego CA), Method and composition for treating thrombosis.
Arai Toshiyuki (26-46 Nishifukunokawa-cho Okazaki ; Sakyo-ku ; Kyoto 606 NY JPX) Gupte Pradeep M. (3 Larissa Ct. Tallman ; Monsey NY 10952) Lasker Sigmund E. (531 Main St. New York NY 10044), Method for introducing oxygen-17 into tissue for imaging in a magnetic resonance imaging system.
Grinstaff Mark W. (Pasadena CA) Desai Neil P. (Los Angeles CA) Suslick Kenneth S. (Champaign IL) Soon-Shiong Patrick (Los Angeles CA) Sandford Paul A. (Los Angeles CA) Merideth Noma R. (Pacific Palis, Method for the preparation of fluorocarbon-containing polymeric shells for medical imaging.
Giddey Claude (Geneva CHX) Dove Georges (Carouge CHX), Method for the preparation of stable suspensions of hollow gas-filled microspheres suitable for ultrasonic echography.
D\Arrigo Joseph S. (Farmington CT), Method for the production of medical-grade lipid-coated microbubbles, paramagnetic labeling of such microbubbles and the.
Bonsen Pieter (Los Altos CA) Wong Patrick S. (Kowloon CA HKX) Theeuwes Felix (Los Altos CA), Method of delivering drug with aid of effervescent activity generated in environment of use.
Lambert Karel J. (San Diego CA) Jablonski Edward G. (Escondido CA) Hulle Carl (San Diego CA), Method of making encapsulated gas microspheres useful as an ultrasonic imaging agent.
Unger Evan C. (Tucson AZ) Fritz Thomas A. (Tucson AZ) Matsunaga Terry (Tucson AZ) Ramaswami VaradaRajan (Tucson AZ) Yellowhair David (Tucson AZ) Wu Guanli (Tucson AZ), Method of preparing gas and gaseous precursor-filled microspheres.
Netting David I. (Springfield PA) Hertzenberg Elliot P. (Wilmington DE), Method of preparing modified hollow, largely spherical particles by spray drying.
Lencki Robert W. J. (1650 Lincoln Ave. ; Apt. 1101 Montreal ; Quebec CAX H3H 1H1) Neufeld Ronald J. (110 Westbank Ave. Pointe Claire ; Quebec CAX H9R 2X6) Spinney Trevor (3739 St. Dominique Montreal , Method of producing microspheres.
Widder Kenneth J. ; Levene Harold B. ; Bales Gary L., Method of ultrasonically quantitating myocardial perfusion using as intravenously injected tracer.
Levene Harold B. (San Diego CA) Villapando Elaine (San Diego CA) Barnhart James L. (Encinitas CA) Widder Kenneth J. (Del Mar CA), Method of ultrasound imaging of the gastrointestinal tract.
Keana John F. W. (Eugene OR), Methods for circumventing the problem of free radial reduction associated with the use of stable nitroxide free radicals.
Unger Evan C. (13365 E. Camino La Cebadilla Tucson AZ 85749), Methods for providing localized therapeutic heat to biological tissues and fluids using gas filled liposomes.
Grinstaff Mark W. (Pasadena CA) Soon-Shiong Patrick (Los Angeles CA) Wong Michael (Champaign IL) Sandford Paul A. (Los Angeles CA) Suslick Kenneth S. (Champaign IL) Desai Neil P. (Los Angeles CA), Methods for the preparation of nucleic acids for in vivo delivery.
Unger Evan C. (Tucson AZ) Fritz Thomas A. (Tucson AZ) Matsunaga Terry (Tucson AZ) Ramaswami VaradaRajan (Tucson AZ) Yellowhair David (Tucson AZ) Wu Guanli (Tucson AZ), Methods of preparing gas-filled liposomes.
Klaveness Jo (Oslo NLX) Rongved Pal (Hellvik NLX) Stubberud Lars (Sodertalje NLX), Microbubble-generating contrast agents for ultrasound and magnetic resonance imaging.
Bara Isabelle (Paris FRX) Mellul Myriam (L\Hay Les Roses FRX), New cosmetic or dermopharmaceutical compositions in the form of aqueous gels modified by the addition of expanded micros.
Schweighardt Frank K. (Allentown PA) Rubertone Joseph A. (Coatesville PA), Perfluoro-crown ethers in fluorine magnetic resonance spectroscopy of biopsied tissue.
Dingle John T. (Whittlesford GB2) Gordon John L. (Cambridge GB2) Jones Geraint (Macclesfield GB2) Knight Clive G. (Huntingdon GB2) Lowe John S. (Wilmslow GB2), Pharmaceutical compositions.
Moore George G. I. (Afton MN) Flynn Richard M. (Mahtomedi MN) Guerra Miguel A. (Woodbury MN), Physiologically acceptable emulsions containing perfluorocarbon ether hydrides and methods for use.
Moore George G. I. (Afton MN) Flynn Richard M. (Mahtomedi MN) Guerra Miguel A. (Woodbury MN), Physiologically acceptable emulsions containing perfluorocarbon ether hydrides and methods of use.
Charpiot Brigitte (Nice FRX) Greiner Jacques (Nice FRX) Le Blanc Maurice (Nice FRX) Manfredi Alexandre (Nice FRX) Riess Jean (Falicon FRX) Zarif Leila (Nice FRX), Polyhydroxylated and highly fluorinated compounds, their preparation and their use as surfactants.
Mathiowitz Edith (Brookline MA) Langer Robert S. (Somerville MA) Warshawsky Abraham (Rehovot MA ILX) Edelman Elazar (Brookline MA), Polymer composite for controlled release or membrane formation.
Halliday Pieter S. J. (Randburg ZAX) Harris Allan J. (Knoppigslaagte ZAX), Process for the production of a cartridged explosive with entrapped bubbles.
Knight Jack V. (Houston TX) Gilbert Brian E. (Houston TX) Wilson Samuel Z. (Houston TX) Six Howard R. (East Stroudsborg PA) Wyde Philip R. (Houston TX), Small particle aerosol liposome and liposome-drug combinations for medical use.
Martin Francis J. (San Francisco CA) Woodle Martin C. (Menlo Park CA) Redemann Carl (Walnut Creek CA) Yau-Young Annie (Palo Alto CA), Solid tumor treatment method and composition.
Schutt Ernest G. (San Diego CA) Evitts David P. (La Jolla CA) Kinner Rene Alta (San Diego CA) Anderson Charles David (Lebanon NJ) Weers Jeffry G. (San Diego CA), Stabilized microbubble compositions.
Schneider Michel (Troinex CHX) Bichon Daniel (Montpellier FRX) Bussat Philippe (Collonge S/Saleve FRX) Puginier Jerome (Le Chable-Beaumont FRX) Hybl-Sutherland Eva (Wiesbaden DEX), Stable microbubbles suspensions injectable into living organisms.
Schneider Michel (Troinex CHX) Bichon Daniel (Montpellier FRX) Bussat Philippe (Collonges S/Saleve FRX) Puginier Jerome (Le Chable-Beaumont FRX) Hybl-Sutherland Eva (Wiesbaden DEX), Stable microbubbles suspensions injectable into living organisms.
Schneider Michel (Troinex CHX) Bichon Daniel (Montpellier FRX) Bussat Philippe (Collonges S/Saleve FRX) Puginier Jerome (Le Chable-Beaumont FRX) Hybl-Sutherland Eva (Wiesbaden DEX), Stable microbubbles suspensions injectable into living organisms.
Schneider Michel (Troinex CHX) Bichon Daniel (Montpellier FRX) Bussat Philippe (Collonges S/Saleve FRX) Puginier Jerome (Le Chable-Beaumont FRX) Hybl-Sutherland Eva (Wiesbaden DEX), Stable microbubbles suspensions injectable into living organisms.
Schneider Michel (Troinex CHX) Bichon Daniel (Montpellier FRX) Bussat Philippe (Collonges S/Saleve FRX) Puginier Jerome (Le Chable-Beaumont FRX) Hybl-Sutherland Eva (Wiesbaden DEX), Stable microbubbles suspensions injectable into living organisms.
Wong Sui-Ming (Collegeville PA) Newington Ian M. (Hazlemere GB2) Liversidge Elaine M. (West Chester PA) McIntire Gregory L. (West Chester PA) Pitt Alan R. (Sandridge GBX) Shaw Jack M. (Aberdeen MD), Sulfated nonionic block copolymer surfactants as stabilizer coatings for nanoparticle compositions.
D\Arrigo Joseph S. (23A Brickyard Rd. Farmington CT 06032), Surfactant mixtures, stable gas-in-liquid emulsions, and methods for the production of such emulsions from said mixtures.
Unger Evan C. (Tucson AZ) Fritz Thomas A. (Tucson AZ) Matsunaga Terry (Tucson AZ) Ramaswami VaradaRajan (Tucson AZ) Yellowhair David (Tucson AZ) Wu Guanli (Tucson AZ), Therapeutic delivery systems related applications.
Popescu Mircea (Plainsboro NJ) Swenson Christine E. (Plainsboro NJ) Johnson Sterling C. (Skillman NJ) Lenk Robert P. (Lambertville NJ), Therapeutic treatment by intramammary infusion.
Reinhardt Michael (Berlin DEX) Fritzsch Thomas (Berlin DEX) Heldmann Dieter (Berlin DEX) Siegert Joachim (Berlin DEX), Ultrasonic contrast agents for color Doppler imaging.
Erbel Raimund (Mainz DEX) Zotz Rainer (Mainz DEX) Krone Volker (Flrsheim DEX) Magerstdt Michael (Hofheim am Taunus DEX) Walch Axel (Frankfurt am Main DEX), Ultrasonic contrast agents, processes for their preparation and the use thereof as diagnostic and therapeutic agents.
Erbel Raimund (Mainz DEX) Zotz Rainer (Mainz DEX) Krone Volker (Flrsheim DEX) Magerstdt Michael (Hofheim am Taunus DEX) Walch Axel (Frankfurt am Main DEX), Ultrasonic contrast agents, processes for their preparation and the use thereof as diagnostic and therapeutic agents.
Erbel Raimund (Mainz) Zotz Rainer (Mainz) Krone Volker (Flrsheim) Magerstdt Michael (Hofheim am Tanus) Walch Axel (Frankfurt am Main DEX), Ultrasonic contrast agents, processes for their preparation and the use thereof as diagnostic and therapeutic agents.
Rasor Ned S. (Cupertino CA) Hilmann Jurgen (Berlin DEX) Lange Lothar (Berlin DEX) Fritzsch Thomas (Berlin DEX) Siegert Joachim (Berlin DEX) Zimmermann Ingfried (Weiler DEX), Ultrasonic contrast medium comprising gas bubbles and solid lipophilic surfactant-containing microparticles and use ther.
Sato, Aaron K.; Sexton, Daniel J.; Dransfield, Daniel T.; Ladner, Robert C.; Arbogast, Christophe; Bussat, Philippe; Fan, Hong; Khurana, Sudha; Linder, Karen E.; Marinelli, Edmund R.; Nanjappan, Palaniappa; Nunn, Adrian D.; Pillai, Radhakrishna K.; Pochon, Sibylle; Yan, Feng; Ramalingam, Kondareddiar; Shrivastava, Ajay; Song, Bo; Swenson, Rolf E.; Von Wronski, Mathew A., KDR and VEGF/KDR binding peptides and their use in diagnosis and therapy.
Sato, Aaron K.; Sexton, Daniel J.; Dransfield, Daniel T.; Ladner, Robert Charles, KDR and VEGF/KDR binding peptides and their use in diagnosis and therapy.
Robinson, Simon P.; Siegler, Robert W.; Nguyen, Nhung Tuyet; Onthank, David C.; Anklekar, Tarakeshwar Vishwanath; Van Kirk, Charles Chester, Methods for making ultrasound contrast agents.
Robinson, Simon P.; Siegler, Robert W.; Nguyen, Nhung Tuyet; Onthank, David C.; Anklekar, Tarakeshwar Vishwanath; Van Kirk, Charles Chester, Methods for making ultrasound contrast agents.
Robinson, Simon P.; Siegler, Robert W.; Nguyen, Nhung Tuyet; Onthank, David C.; Anklekar, Tarakeshwar Vishwanath; Van Kirk, Charles Chester, Methods for making ultrasound contrast agents.
Fan, Hong; Marinelli, Edmund R.; Nanjappan, Palaniappa; Pillai, Radhakrishna; Swenson, Rolf E., Methods for preparing multivalent constructs for therapeutic and diagnostic applications and methods of preparing the same.
Gulati, Sandeep; Ruchti, Timothy L.; Smith, John L.; Van Antwerp, William, Spectroscopic tomography systems and methods for noninvasive detection and measurement of analytes using collision computing.
Gulati, Sandeep; Ruchti, Timothy L.; Van Antwerp, William; Smith, John L., Systems and methods for blood glucose and other analyte detection and measurement using collision computing.
Gulati, Sandeep; Ruchti, Timothy L.; Van Antwerp, William; Smith, John L., Systems and methods for collision computing for detection and noninvasive measurement of blood glucose and other substances and events.
Gulati, Sandeep; Ruchti, Timothy L.; Smith, John L.; Van Antwerp, William, Systems and methods for control of illumination or radiation collection for blood glucose and other analyte detection and measurement using collision computing.
Gulati, Sandeep; Ruchti, Timothy L.; Van Antwerp, William; Smith, John L., Systems and methods for generating and using projector curve sets for universal calibration for noninvasive blood glucose and other measurements.
Gulati, Sandeep; Ruchti, Timothy L.; Smith, John L., Systems and methods for measurement of heart rate and other heart-related characteristics from photoplethysmographic (PPG) signals using collision computing.
Gulati, Sandeep; Ruchti, Timothy L.; Antwerp, William V.; Smith, John L., Systems and methods for noninvasive blood glucose and other analyte detection and measurement using collision computing.
Gulati, Sandeep; Ruchti, Timothy L.; Van Antwerp, William; Smith, John L., Systems and methods for noninvasive blood glucose and other analyte detection and measurement using collision computing.
Gulati, Sandeep; Ruchti, Timothy L., Systems and methods for synthesis of zyotons for use in collision computing for noninvasive blood glucose and other measurements.
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