Cosmetic or dermatological use of 7-hydroxylated steroids in combination with elastin derived peptides
원문보기
IPC분류정보
국가/구분
United States(US) Patent
등록
국제특허분류(IPC7판)
A61K-038/00
A61K-031/56
출원번호
US-0443631
(1999-11-19)
발명자
/ 주소
Mitts, Thomas F.
Sandberg, Lawrence B.
Roos, Philip J.
출원인 / 주소
Connective Tissue Imagineering LLC
대리인 / 주소
Benesch, Friedlander, Coplan & Aronoff, LLP
인용정보
피인용 횟수 :
12인용 특허 :
37
초록▼
The present invention is directed to a composition and method for enhancing the appearance of skin or tissue. The invention is preferably a combination of elastin-derived peptides and steroidal compounds useful in the treatment of problems associated with deficient elastin or conditions that would b
The present invention is directed to a composition and method for enhancing the appearance of skin or tissue. The invention is preferably a combination of elastin-derived peptides and steroidal compounds useful in the treatment of problems associated with deficient elastin or conditions that would benefit from increased elastin.
대표청구항▼
1. A therapeutic composition comprised of a compound corresponding to the formula:or the formulain whichR1 is selected from the group consisting of: a hydrogen atom, functional groups which are an ester of an organic acid with 1 to 24 carbon atoms, a sulphate ester, a phosphate ester, a carbonaceous
1. A therapeutic composition comprised of a compound corresponding to the formula:or the formulain whichR1 is selected from the group consisting of: a hydrogen atom, functional groups which are an ester of an organic acid with 1 to 24 carbon atoms, a sulphate ester, a phosphate ester, a carbonaceous ether with 1 to 24 atoms of carbon that includes or does not include nitrogen atoms, carbohydrate ethers with 3 to 100 carbon atoms;R2 is selected from the group consisting of: a hydrogen atom or a functional group that is an ester of a fatty acid with 1 to 24 carbon atoms;R3 is selected from the group consisting of: a hydrogen atom, an —OH group, groups of formula: —CO—R4, —CHOH—R4, ═CH—CH3, ═COH—CH3, —CHR4—CH3, ═O, in which R4 is a substituted or non-substituted alkyl group containing from 1 to 10 carbon atoms;an elastin peptide fragment selected from the group consisting of SEQ ID NO:17 (Valine-Valine-Proline-Glutamine), SEQ ID NO:18 (Valine-Alanine-Alanine-Arginine-Proline-Glycine), SEQ ID NO:19 (Leucine-Glycine-Alanine-Glycine-Glycine-Alanine-Glycine), and SEQ ID NO: 23 (Valine-Glycine-Valine-Hydroxyproline-Glycine); anda carrier. 2. The composition of claim 1, wherein said elastin peptide fragment is at a therapeutically effective concentration. 3. The composition of claim 2, wherein said therapeutically effective concentration is a range of about 0.0002% to about 90% by weight. 4. The composition of claim 3, wherein said therapeutically effective concentration is in the range of about 0.5% to about 10% by weight. 5. The composition of claim 1, wherein said composition is a cosmetic preparation. 6. The composition of claim 5, wherein said cosmetic preparation is selected from the group consisting of an emulsion, lotion, spray, aerosol, powder, ointment, cream and foam. 7. The composition of claim 1, wherein said composition further comprises a delivery system selected from the group consisting of a topical delivery system, a subcutaneous delivery system, a transcutaneous delivery, an oral delivery system, a nasal delivery system, an aerosol delivery system, and a patch delivery system. 8. The composition of claim 1 further comprising a second elastin peptide fragment selected from the group consisting of SEQ ID NO:1 (Alanine-Valine-Glycine), SEQ ID NO:2 (Valine-Glycine-Alanine-Glycine), SEQ ID NO:3 (Isoleucine-Glycine-Glycine), SEQ ID NO:4 (Leucine-Glycine), SEQ ID NO:5 (Isoleucine-Glycine-Alanine-Glycine), SEQ ID) NO:6 (Leucine-Glycine-Glycine), SEQ ID NO:7 (Valine-Alanine-Proline-Glycine), SEQ ID NO:8 (Leucine-Glycine-Proline-Glycine), SEQ ID NO:9 (Leucine-Glycine-Alanine-Glycine), SEQ ID NO:10 (Valine-Glycine-Proline-Glycine), SEQ ID NO:11 (Phenylalanine-Glycine-Proline-Glycine) SEQ ID NO:12 (Valine-Glycine-Proline-Glutamine), SEQ ID NO:13, (Leucine-Glycine-Alanine), SEQ ID NO:14 (Valine-Glycine-Proline-Alanine), SEQ ID NO:15 (Valine-Valine-Proline-Glycine), SEQ ID NO:16, (Alanine-Valine-Proline-Glycine), SEQ ID NO:17 (Valine-Valine-Proline-Glutamine), SEQ ID NO:18 (Valine-Alanine-Alanine-Arginine-Proline-Glycine), SEQ ID NO:19 (Leucine-Glycine-Alanine-Glycine-Glycine-Alanine-Glycine), SEQ ID NO:20 (Alanine-Isoleucine-Proline-Glycine), SEQ ID NO:21 (Leucine-Glycine-Proline-Glycine-Glycine), SEQ ID NO:22 (Alanine-Alanine-Alanine-Glutamine-Alanine), SEQ ID NO: 23 (Valine-Glycine-Valine-Hydroxyproline-Glycine), SEQ ID NO:24 (Valine-Tyrosine-Proline-Glycine-Glycine), SEQ ID NO:25 (Isoleucine-Glycine-Glycine-Valine-Glycine-Glycine), SEQ ID NO:26 (Valine-Alanine-Proline-Glycine-Valine-Glycine), SEQ ID NO:27 (Leucine-Glycine-Valine-Glycine-Glycine), SEQ ID NO:28 (Valine-Leucine-Proline-Glycine), SEQ ID NO:29 (Phenylalanine-Arginine-Alanine-Alanine-Alanine), SEQ ID NO:30 (Valine-Glycine-Glycine-Valine-Proline-Glycine), SEQ ID NO:31 (Phenylalanine-Glycine-Proline-Glycine-Glycine), SEQ ID NO:32 (Valine-Glycine-Valine-Proline-Glycine), SEQ ID NO:33 ( Valine-Leucine-Proline-Glycine-Alanine-Glycine), SEQ ID NO:34 (Valine-Glycine-Leucine-Hydroxyproline-Glycine), SEQ ID NO:35 (Leucine-Glycine-Valine-Glycine-Alanine), SEQ ID NO:36 (Alanine-Phenylalanine-Proline-Glycine), SEQ ID NO:37 (Alanine-Phenylalanine-Proline-Glycine-Alanine), SEQ ID NO:38 (Valine-Glycine-Isoleucine-Proline-Alanine), SEQ ID NO:39 (Valine-Glycine-Glycine-Isoleucine-Proline-Threonine), SEQ ID NO:40 (Valine-Glycine-Valine-Glycine-Valine-Proline-Glycine), and SEQ ID NO:41 (Leucine-Glycine-Proline-Glycine-Valine-Glycine), wherein said second elastin peptide fragment is different from said elastin peptide fragment. 9. The composition of claim 8, wherein said elastin peptide fragment and said second elastin peptide fragment are of a therapeutically effective range of about 0.0002% to 90% by weight. 10. The composition of claim 8, wherein said composition is a cosmetic preparation. 11. The composition of claim 10, wherein said cosmetic preparation is selected from the group consisting of an emulsion, lotion, spray, aerosol, powder, ointment, cream and foam.
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