IVC rack system and method for detecting infections particles within an IVC rack system
IPC분류정보
국가/구분 |
United States(US) Patent
등록
|
국제특허분류(IPC7판) |
|
출원번호 |
US-0296691
(2000-06-06)
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국제출원번호 |
PCT/EP00/05199
(2000-06-06)
|
국제공개번호 |
WO01/91543
(2001-12-06)
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발명자
/ 주소 |
- Schmidt, Jö
- rg
- Brielmeier, Markus
|
출원인 / 주소 |
- GSF-Forschungszentrum fur Umwelt und Gesundheit GmbH
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대리인 / 주소 |
|
인용정보 |
피인용 횟수 :
5 인용 특허 :
9 |
초록
▼
IVC rack system comprising a plurality of IVC cages 13 for test animals which are supplied with sterile air, wherein samples of exhaust air from the IVC cages 13 are supplied from sampling points 15 to at least one sentinel cage 24 housing sentinel animals as bio-indicators for the detection of infe
IVC rack system comprising a plurality of IVC cages 13 for test animals which are supplied with sterile air, wherein samples of exhaust air from the IVC cages 13 are supplied from sampling points 15 to at least one sentinel cage 24 housing sentinel animals as bio-indicators for the detection of infectious particles within the exhaust air samples, and to at least one particle sampling filter 33 for the identification of pathogens.
대표청구항
▼
1. An individually ventilated microisolator-cages (IVC) rack system comprising a plurality of IVC cages for housing test animals, means for individually supplying the cages with sterile air, a sentinel cage for housing a sentinel animal, and means for supplying the sentinel cage with exhaust air fro
1. An individually ventilated microisolator-cages (IVC) rack system comprising a plurality of IVC cages for housing test animals, means for individually supplying the cages with sterile air, a sentinel cage for housing a sentinel animal, and means for supplying the sentinel cage with exhaust air from the IVC cages, wherein the sentinel animal serves as a bio-indicator for the detection of infectious particles within the exhaust air samples. 2. The IVC rack system according to claim 1, wherein the sentinel cage and the IVC cages comprise pressure gauges for measuring pressure within the cages. 3. The IVC rack system according to claim 1, wherein the sentinel cage comprises an input air-flow regulation valve for regulating the influx of exhaust air into the sentinel cage. 4. The IVC rack system according to claim 1, wherein the sentinel cage comprises an output air-flow regulation valve for regulating the outflow of exhaust air from the sentinel cage. 5. The IVC rack system according to claim 1, wherein the sterile air supplying means comprises a manifold, and further comprising an air supply diffuser mounted on each of the cages, wherein the sterile air enters the IVC cages through the air supply diffusers. 6. The IVC rack system according to claim 1, wherein the sterile air supplying means comprises an input particle filter unit including a pre-filter, means for supplying ambient room air to the pre-filter, and a HEPA-filter connected to the pre-filter to generate the sterile air from the pre-filtered ambient room air. 7. The IVC rack system according to one claim 1, further comprising an output particle filter unit including a pre-filter which filters the exhaust air from the IVC cages and the exhaust air from the sentinel cage; and a HEPA-filter connected to the pre-filter. 8. The IVC rack system according to claim 1, wherein the test sentinel animal is selected from laboratory mice, gerbils, hamsters or rats. 9. The IVC rack system according to claim 1, wherein the exhaust air supplying means comprises a sampling point provided for a subset of IVC cages within the IVC rack system. 10. The IVC rack system according to claim 1, wherein the exhaust air supplying means comprises an exhaust plenum, and a sampling point provided at the vertical exhaust plenum. 11. The IVC rack system according to claim 1, wherein the exhaust air supplying means comprises a sampling point for each IVC cage within the IVC rack system. 12. The IVC rack system according to claim 1, further comprising a particle sampling filter for sampling infectious particles supplied to the sentinel cage. 13. Method for detecting infectious particles within an individually ventilated microisolator-cages (IVC) rack system, wherein each IVC cage is provided for housing test animals, the method comprising the following steps:(a) filtering of ambient air to generate sterile air;(b) supplying the IVC cages of the IVC rack system with the sterile air;(c) providing a sentinel cage housing a sentinel animal;(d) supplying the sentinel cage with exhaust air from the IVC cages; and(e) detecting infectious particles within the exhaust air by means of the sentinel animals which act as bio-indicators. 14. The method according to claim 13, further comprising the steps of filtering the exhaust air, and detecting the infectious particles within the filtered exhaust air.
이 특허에 인용된 특허 (9)
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Harr James R. (51 Ridge Rd. East Rochester NY 14621), Air conditioned laboratory rack for animal cages.
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Thomas William R. (325 W. Seventh St. Hazelton PA 18201), Animal caging system.
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Leong Basil K. J. (Kalamazoo MI), Animal inhalation exposure system.
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Coiro ; Sr. Michael A. ; Herdt Frank J. ; Bilecki Brian M., Bio-containment animal cage system.
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Semenuk Michael D. ; Norwood Richard A., Cage for laboratory animal.
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Solman Arthur J. (Monks Risborough GB2) Evans Graham P. (Marlow GB2), Continuous monitoring of water quality.
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Moss Owen R. (Kennewick WA) Briant James K. (Pasco WA), Exposure chamber.
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Biederman Gerald Bernard (113 Argonne Crescent Willowdale ; Ontario CA), Method and apparatus for use in detecting faint olfactory stimuli.
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Miraldi Peter T. (Erie PA) Barron William R. (McKean PA) Ruffo Anthony B. (Erie PA), Micro-isolator steam sterilization cycle and apparatus.
이 특허를 인용한 특허 (5)
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Yanai, Ehud; Elazari-Volcani, Ron, System and methods for health monitoring of anonymous animals in livestock groups.
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Brasfield, Freddie R., Target odor detection and security apparatus.
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Brasfield, Freddie R., Target odor detection and security apparatus.
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Brasfield, Freddie R., Target odor detection and security apparatus.
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Brasfield, Freddie R., Target odor detection and security method.
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