초록 ▼

A dual drug containing adhesive transdermal drug delivery system comprising: a support layer, a first drug containing adhesive layer and a second drug containing adhesive layer each of said layers having a proximal and distal surface wherein each layer is positioned adjacent to the other with each l

A dual drug containing adhesive transdermal drug delivery system comprising: a support layer, a first drug containing adhesive layer and a second drug containing adhesive layer each of said layers having a proximal and distal surface wherein each layer is positioned adjacent to the other with each layer having its distal surface laminated to said support layer, and a peelable backing layer positioned over and laminated to the proximal surface of said first and second adhesive layers is disclosed.

대표청구항 ▼

1. A dual drug containing adhesive transdermal drug delivery system comprising:1)a support layer,2) pressure-sensitive adhesive layers comprising a first drug containing adhesive layer and a second drug containing adhesive layer, each of said layers having a proximal surface and a distal surface,whe

1. A dual drug containing adhesive transdermal drug delivery system comprising:1)a support layer,2) pressure-sensitive adhesive layers comprising a first drug containing adhesive layer and a second drug containing adhesive layer, each of said layers having a proximal surface and a distal surface,wherein said first and second adhesive layers are positioned adjacent to each other, the distal surface of each said adhesive layer is laminated to said support layer, the solubility of a drug in said first adhesive layer is within the range of 1.0 to 20 mg/ml, and the solubility of the drug in said second adhesive layer is within the range of 30 to 200 mg/ml, and3) a peelable backing layer positioned over and laminated to the proximal surface of said first and second adhesive layers. 2. The dual drug containing adhesive transdermal drug delivery system of claim 1, wherein the drug content of in said first adhesive layer is within the range of 0.1 to 5.0 wt %. 3. The dual drug containing adhesive transdermal drug delivery system of claim 1, wherein the drug content of in said second adhesive layer is within the range of 1.0 to 20 wt %. 4. The dual drug containing adhesive transdermal drug delivery system of claim 1, wherein the adhesive polymer of said first adhesive layer is a member selected from the group consisting of silicone adhesives, modified silicone adhesives, and mixtures thereof. 5. The dual drug containing adhesive transdermal drug delivery system of claim 1, wherein the adhesive polymer of said second adhesive layer is a member selected from the group consisting of acrylate adhesives, acrylate copolymer adhesives, isobutylene adhesives, and mixtures thereof. 6. The dual drug containing adhesive transdermal drug delivery system of claim 1, wherein the first or second adhesive layer further comprises a penetration enhancer. 7. The dual drug containing adhesive transdermal drug delivery system of claim 1, wherein the drug is a member selected from the group consisting of antibiotics; antiviral agents; analgesic agents; anorexics; anthelmintics; antiarthritics; antiasthmatic agents; anticonvulsants; antidepressants; antidiabetic agents; antidiarrheals; antihistamines; antiinflammatory agents; antimigraine agents; antinauseants; antineoplastics; antiparkinsonism drugs; antipruritics; antipsychotics; antipyretics; antispasmodics; anticholinergics; sympathomimetics; xanthine derivatives; cardiovascular drugs; antiarrhythmics; antihypertensives; diuretics; antidiuretics; vasodilators; vasoconstrictors; decongestants; hormones; immunosuppressives; muscle relaxants; parasympatholytics; psychostimulants; sedatives; and tranquilizers. 8. The dual drug containing adhesive transdermal drug delivery system of claim 1, wherein the drug is an analgesic agent. 9. The dual drug containing adhesive transdermal drug delivery system of claim 1, wherein the drug is fentanyl. 10. The dual drug containing adhesive transdermal drug delivery system of claim 9, wherein the content of fentanyl in said first adhesive layer is within the range of 0.1 to 5.0 wt % the content of fentanyl in said second adhesive layer is within the range of 1.0 to 20 wt %. 11. The dual drug containing adhesive transdermal drug delivery system of claim 9, wherein the adhesive polymer of said second adhesive layer is an acrylate copolymer adhesive. 12. The dual drug containing adhesive transdermal drug delivery system of claim 9, wherein the first and the second adhesive layers of said dual have a surface ratio within the range of 1:9 to 3:2. 13. The dual drug containing adhesive drug delivery system of claim 9, wherein the first and the second adhesive layers have a surface ratio within the range of 1:4 to 2:3.