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Provided is a preparative method for isolating RNA comprising an oligo- or polynucleotide from a sample, which method comprises: (a) treating the sample with a reactant capable of covalently modifying the 2′-OH position of the ribose rings of the RNA under conditions so that a proportion of t

Provided is a preparative method for isolating RNA comprising an oligo- or polynucleotide from a sample, which method comprises: (a) treating the sample with a reactant capable of covalently modifying the 2′-OH position of the ribose rings of the RNA under conditions so that a proportion of the 2′-OH positions of the ribose rings bear a substituent; and (b) preparing isolated RNA therefrom by separating material containing the substituent from the sample on the basis of a property of the substituent.

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1. A method of isolating RNA comprising an oligo- or polynucleotide from a sample comprising the steps of:(a) treating the sample with a reactant capable of covalently modifying the 2′-OH position of the ribose rings of the RNA under conditions so that a proportion of the 2′-OH positio

1. A method of isolating RNA comprising an oligo- or polynucleotide from a sample comprising the steps of:(a) treating the sample with a reactant capable of covalently modifying the 2′-OH position of the ribose rings of the RNA under conditions so that a proportion of the 2′-OH positions of the ribose rings bear a substituent; and(b) preparing isolated RNA therefrom by separating material containing the substituent from the sample on the basis of a property of the substituent. 2. A kit for the preparative isolation of RNA comprising an oligo- or polynucleotide from a sample, which kit comprises:(i) a reaction system comprising a reactant that will covalently modify the 2′-OH position of the ribose rings of RNA such that a proportion of the 2′-OH positions of the ribose rings of said RNA will bear a substituent; and(ii) a separation system comprising a separating material that will isolate the RNA comprising said substituent from the sample on the basis of a property of said substituent. 3. A preparative device for isolating RNA comprising an oligo-or polynucleotide from a sample from a subject, which device comprises:(i) a means for extracting the sample from the subject;(ii) a reaction system comprising a reactant that will covalently modify the 2′-OH position of the ribose rings of RNA such that a proportion of the 2′-OH positions of the ribose rings of said RNA will bear a substituent; and(iii) a separation system comprising a separating material that will isolate the RNA comprising said substituent from the sample on the basis of a property of said substituent.