[특허]Use of penetration enhancers and barrier disruption agents to enhance the transcutaneous immune response

Use of penetration enhancers and barrier disruption agents to enhance the transcutaneous immune response 원문보기

IPC분류정보
국가/구분	United States(US) Patent 등록
국제특허분류(IPC7판)	A61K-045/00 A61K-047/00
출원번호	US-0257188 (1999-02-25)
발명자 / 주소	Glenn, Gregory M. Alving, Carl R.
출원인 / 주소	The United States of America as represented by the Secretary of the Army
대리인 / 주소	Morgan, Lewis & Bockius LLP
인용정보	피인용 횟수 : 65 인용 특허 : 218

초록 ▼

A transcutaneous immunization system where the topical application of an adjuvant and an antigen or nucleic acid encoding for an antigen, to intact skin induces a ystemic or mucosol antibody response. The immune response so elicited can be enhanced by physical or chemical skin penetration enhancemen

대표청구항 ▼

1. A method for inducing an antigen specific immune response in a subject comprising:a. pretreating an are of the skin of said subject; andb. applying a formulation to said pretreated area, wherein said formulation comprises:1) at least one antigen sufficient to induce an antigen-specific immune response against a pathogen,2) at least one adjuvant present in an amount effective to induce said immune response to said at least one antigen; and,3) a pharmaceutically acceptable carrier, wherein said pretreating enhances skin penetration by said formulation and thereby induces said immune response,wherein said pretreating is selected from the group consisting of direct application to said skin, rubbing, swabbing, applying a depilatory agent, applying a keratinolytic formulation, shaving, tape stripping, abrading and a combination thereof. 2. The method of claim 1, wherein said swabbing comprises a swab comprising a material selected from the group consisting of cotton, nylon, wool and combinations thereof. 3. The method of claim 2, wherein said swab further comprises an alcohol, a composition comprising an alcohol, acetone, a composition comprising acetone, a detergent or a detergent solution. 4. The method of claim 1 wherein said pretreating comprises applying a detergent or a detergent solution to said pretreated area. 5. The method of claim 1, wherein said antigen is derived from a pathogen selected from the group consisting of virus, bacteria, fungus and parasite. 6. The method of claim 1, wherein said antigen is derived from an influenza virus. 7. The method of claim 6, wherein said antigen is hemaglutinin A. 8. The method of claim 1, wherein said antigen is derived from a bacteria. 9. The method of claim 8, wherein said antigen is E. coli heat-labile entertoxin (LT). 10. The method of claim 1, further comprising a carrier, wherein said carrier is a patch. 11. The method of claim 10, wherein said patch is selected from the group consisting of an occlusive dressing, a nonocclusive dressing, a hydrogel dressing and a reservoir dressing.

이 특허에 인용된 특허 (218)

Digenis George A. (Lexington KY) Doll Walter J. (Lexington KY) Hawi Amale (Lexington KY), 3-hydroxy-N-methylpyrrolidone and use as transdermal enhancer.
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Use of penetration enhancers and barrier disruption agents to enhance the transcutaneous immune response 원문보기

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Use of penetration enhancers and barrier disruption agents to enhance the transcutaneous immune response 원문보기

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