[특허]Solid dose delivery vehicle and methods of making same

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Solid dose delivery vehicle and methods of making same 원문보기

IPC분류정보
국가/구분	United States(US) Patent 등록
국제특허분류(IPC7판)	A61F-002/02 A61K-013/02 A61K-009/70 A61K-009/50
출원번호	US-0280468 (2002-10-25)
발명자 / 주소	Roser, Bruce J. Kampinga, Jaap Colaco, Camilo Blair, Julian
출원인 / 주소	Quadrant Drug Delivery Ltd.
대리인 / 주소	Saliwanchik, Lloyd & Saliwanchik
인용정보	피인용 횟수 : 189 인용 특허 : 57

초록 ▼

The present invention encompasses a solid dose delivery vehicle for ballistic administration of a bioactive material to subcutaneous and intradermal tissue, the delivery vehicle being sized and shaped for penetrating the epidermis. The delivery vehicle further comprises a stabilizing polyol glass loaded with the bioactive material and capable of releasing the bioactive material in situ. The present invention further includes methods of making and using the solid dose delivery vehicle of the invention.

대표청구항 ▼

1. A solid dose delivery vehicle suitable for administration by ballistic delivery, comprising a solid solution of bioactive material in a stabilizing polyol glass continuous phase. 2. The solid dose delivery vehicle as claimed in claim 1, wherein the vehicle is in the form of uniform microspheres of narrow size distribution suitable for administration to the basal layers of the epidermis. 3. A solid dose delivery vehicle suitable for administration by ballistic delivery, comprising a stabilizing polyol and a bioactive agent, loaded onto a vehicle. 4. The solid dose delivery vehicle as claimed in claim 1, wherein the bioactive material is a prophylactic for use as a vaccine. 5. The solid dose delivery vehicle as claimed in claim 1, wherein the bioactive material is DNA. 6. The solid dose delivery vehicle as claimed in claim 1, wherein the bioactive material comprises an antigen and an adjuvant. 7. The solid dose delivery vehicle as claimed in claim 1, wherein the polyol is selected from the group consisting of disaccharides, trisaccharides and oligosaccharides. 8. The solid dose delivery vehicle as claimed in claim 1, wherein the polyol is trehalose. 9. A vaccine composition comprising a solid dose delivery vehicle suitable for administration by ballistic delivery, comprising a solid solution of bioactive material in a stabilizing polyol glass continuous phase and wherein the bioactive material is a DNA plasmid encoding an immunogen. 10. The vaccine composition as claimed in claim 9, further comprising an amount of an adjuvant sufficient to enhance the immune response to the immunogen. 11. A device for ballistic delivery, comprising a solid dose delivery vehicle suitable for administration by ballistic delivery, comprising a solid solution of bioactive material in a stabilizing polyol glass continuous phase. 12. A device for subdermal delivery of a therapeutic agent, wherein the device includes a solid dose delivery vehicle comprising a therapeutically effective amount of said therapeutic agent and polyol. 13. The device according to claim 12, wherein the polyol is a stabilizing polyol. 14. The device according to claim 12, wherein the polyol is selected from the group consisting of disaccharides, trisaccharides and oligosaccharide.

이 특허에 인용된 특허 (57)

Nishikawa Yoshihiro (Kanazawa JPX) Kanemitsu Kimihiro (Kanazawa JPX) Katori Tatsuhiko (Ibaragi JPX) Shibata Akihiro (Narashino JPX) Kukita Kenichi (Kashiwa JPX), aa 상세보기

Drake ; Jr. James F. (Minneapolis MN) Paul ; Jr. Fred R. (Burnsville MN), Ballistic animal implant.

상세보기

Kwan Henry K. H. (Summit NJ), Biologically stable interferon compositions comprising thimerosal.

상세보기

Wang Yu-chang J. (Los Altos CA) Lee William A. (Los Altos CA) Narog Blair (Palo Alto CA), Composition and method for administration of pharmaceutically active substances.

상세보기

Puglia Wayne J. (Bellerose Village NY) Patanasinth Kanit J. (Tarrytown NY) Lombardo Andrew T. (Bronx NY) Beam John E. (Norwalk CT) Mackay Donald A. M. (Pleasantville NY), Compressed chewable antacid tablet and method for forming same.

상세보기

Puglia Wayne J. (Bellerose Village NY) Patanasinth Kanit J. (Tarrytown NY) Lombardo Andrew T. (Bronx NY) Vink Walter (Purdys Station NY), Compressed chewable antacid tablet and method for forming same.

상세보기

Portenhauser Rudolf (Tutzing DEX) Bartl Knut (Wilzhofen DEX), Control or calibration serum for lipid diagnosis.

상세보기

Drake Cyril F. (Harlow GB2) Arch Alfred J. (Ongar GB2), Controlled delivery device.

상세보기

Drake Cyril F. (Harlow GBX), Controlled delivery devices.

상세보기

Mitsuhashi Masakazu (Okayama JPX) Sakai Shuzo (Okayama JPX) Miyake Toshio (Okayama JPX), Dehydration of hydrous matter using anhydrous glycosylfructose.

상세보기

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Lum, Paul, Method and apparatus for improving fluidic flow and sample capture.
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Lum, Paul; Mauze, Ganapati; Poplonski, Tomasz; Shatsky, Rebecca, Method and apparatus for improving fluidic flow and sample capture.
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Alden, Don; Freeman, Dominique M.; Lum, Paul; Drbal, Vladimir; Boecker, Dirk; Verdonk, Edward D., Method and apparatus for improving success rate of blood yield from a fingerstick.
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Briggs,Barry Dean; Freeman,Dominique M.; Alden,Don; Leonard,Jon Hewitt; Boecker,Dirk, Method and apparatus for lancet actuation.
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Alden, Don; Freeman, Dominique M.; Lum, Paul, Method and apparatus for lancet launching device integrated onto a blood-sampling cartridge.
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Alden, Don; Freeman, Dominique M.; Lum, Paul, Method and apparatus for lancet launching device integrated onto a blood-sampling cartridge.
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Alden, Don; Freeman, Dominique M.; Lum, Paul, Method and apparatus for lancet launching device intergrated onto a blood-sampling cartridge.
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Freeman, Dominique; Alden, Don; Boecker, Dirk; Cane, Mike; Schumann, Matt; Beadman, Mike, Method and apparatus for multi-use body fluid sampling device with sterility barrier release.
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Boecker, Dirk; Alden, Don; Freeman, Dominique M., Method and apparatus for penetrating tissue.
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Boecker, Dirk; Alden, Don; Freeman, Dominique M., Method and apparatus for penetrating tissue.
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Boecker, Dirk; Alden, Don; Freeman, Dominique M., Method and apparatus for penetrating tissue.
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Boecker, Dirk; Alden, Don; Freeman, Dominique M., Method and apparatus for penetrating tissue.
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Boecker, Dirk; Alden, Don; Freeman, Dominique M., Method and apparatus for penetrating tissue.
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Boecker, Dirk; Alden, Don; Freeman, Dominique M., Method and apparatus for penetrating tissue.
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Boecker, Dirk; Alden, Don; Freeman, Dominique M., Method and apparatus for penetrating tissue.
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Boecker, Dirk; Alden, Don; Freeman, Dominique M., Method and apparatus for penetrating tissue.
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Boecker,Dirk; Alden,Don; Freeman,Dominique M., Method and apparatus for penetrating tissue.
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Boecker,Dirk; Alden,Don; Freeman,Dominique M., Method and apparatus for penetrating tissue.
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Boecker,Dirk; Alden,Don; Freeman,Dominique M., Method and apparatus for penetrating tissue.
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Boecker,Dirk; Alden,Don; Freeman,Dominique M., Method and apparatus for penetrating tissue.
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Boecker,Dirk; Alden,Don; Freeman,Dominique M., Method and apparatus for penetrating tissue.
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Boecker,Dirk; Alden,Don; Freeman,Dominique M., Method and apparatus for penetrating tissue.
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Boecker,Dirk; Alden,Don; Freeman,Dominique M., Method and apparatus for penetrating tissue.
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Freeman, Dominique, Method and apparatus for penetrating tissue.
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Freeman, Dominique M., Method and apparatus for penetrating tissue.
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Freeman, Dominique M., Method and apparatus for penetrating tissue.
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Freeman, Dominique M.; Alden, Don; Boecker, Dirk, Method and apparatus for penetrating tissue.
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Freeman, Dominique M.; Boecker, Dirk; Alden, Don, Method and apparatus for penetrating tissue.
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Freeman, Dominique M.; Boecker, Dirk; Alden, Don, Method and apparatus for penetrating tissue.
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Freeman, Dominique M.; Boecker, Dirk; Alden, Don, Method and apparatus for penetrating tissue.
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Freeman, Dominique M.; Boecker, Dirk; Alden, Don, Method and apparatus for penetrating tissue.
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Freeman, Dominique M.; Boecker, Dirk; Alden, Don, Method and apparatus for penetrating tissue.
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Freeman, Dominique M.; Boecker, Dirk; Alden, Don, Method and apparatus for penetrating tissue.
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Freeman, Dominique M.; Boecker, Dirk; Alden, Don, Method and apparatus for penetrating tissue.
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Freeman, Dominique M.; Boecker, Dirk; Alden, Don, Method and apparatus for penetrating tissue.
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Freeman, Dominique M.; Boecker, Dirk; Alden, Don; Hegener, Jason, Method and apparatus for penetrating tissue.
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Freeman, Dominique; Alden, Don, Method and apparatus for penetrating tissue.
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Freeman, Dominique; Alden, Don, Method and apparatus for penetrating tissue.
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Freeman, Dominique; Alden, Don, Method and apparatus for penetrating tissue.
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Freeman, Dominique; Alden, Don, Method and apparatus for penetrating tissue.
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Freeman, Dominique; Alden, Don, Method and apparatus for penetrating tissue.
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Freeman, Dominique; Boecker, Dirk; Alden, Don, Method and apparatus for penetrating tissue.
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Freeman, Dominique; Boecker, Dirk; Alden, Don, Method and apparatus for penetrating tissue.
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Freeman, Dominique; Boecker, Dirk; Alden, Don, Method and apparatus for penetrating tissue.
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Freeman, Dominique; Boecker, Dirk; Alden, Don, Method and apparatus for penetrating tissue.
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Freeman, Dominique; Boecker, Dirk; Alden, Don, Method and apparatus for penetrating tissue.
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Freeman,Dominique M.; Boecker,Dirk; Alden,Don, Method and apparatus for penetrating tissue.
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Freeman,Dominique M.; Boecker,Dirk; Alden,Don, Method and apparatus for penetrating tissue.
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Freeman,Dominique M.; Boecker,Dirk; Alden,Don, Method and apparatus for penetrating tissue.
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Freeman,Dominique M.; Boecker,Dirk; Alden,Don, Method and apparatus for penetrating tissue.
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Freeman, Dominique M.; Boccker, Dirk; Jones, Robert; Cullen, David; MacLood, Malcolm; Carlson, William; Owen, Michael J.; Dryer, Christopher, Method and apparatus using optical techniques to measure analyte levels.
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Freeman, Dominique M.; Boecker, Dirk; Jones, Robert; Cullen, David; MacLeod, Malcolm; Carlsen, William; Owen, Michael J.; Dryer, Christopher, Method and apparatus using optical techniques to measure analyte levels.
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Freeman, Dominique M.; Alden, Don, Method for penetrating tissue.
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Freeman, Dominique; Alden, Don, Method for penetrating tissue.
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Alden, Don; Marsot, Travis, Method of manufacturing a fluid sampling device with improved analyte detecting member configuration.
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Briggs, Barry Dean; Freeman, Dominique; Alden, Don; Boecker, Dirk, Methods and apparatus for lancet actuation.
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Briggs, Barry; Freeman, Dominique; Alden, Don; Boecker, Dirk, Methods and apparatus for lancet actuation.
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Briggs, Barry; Freeman, Dominique; Alden, Don; Boecker, Dirk, Methods and apparatus for lancet actuation.
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Briggs, Barry; Freeman, Dominique; Boecker, Dirk; Alden, Don, Methods and apparatus for lancet actuation.
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Briggs, Barry; Freeman, Dominique; Boecker, Dirk; Alden, Don, Methods and apparatus for lancet actuation.
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Castle, Mark; Kugizaki, Rodney; Englert, Robert; Shoup, Thomas; Freeman, Dominique M., Methods and apparatus for lancet actuation.
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Castle, Mark; Kugizaki, Rodney; Englert, Robert; Shoup, Thomas; Perry, Jeff, Methods and apparatus for lancet actuation.
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Boecker, Dirk; Alden, Don; Freeman, Dominique M., Methods and apparatus for penetrating tissue.
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Patton, John S.; Foster, Linda S.; Platz, Robert M., Methods and compositions for pulmonary delivery of insulin.
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Rosinko, Michael J.; DiPerna, Paul M., Methods and devices for determination of flow reservoir volume.
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Rosinko, Michael J; DiPerna, Paul M., Methods and devices for determination of flow reservoir volume.
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Harel, Moti; Carpenter, Brian, Microparticulated vaccines for the oral or nasal vaccination and boostering of animals including fish.
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Van De Wijdeven, Gijsbertus Gerardus Petrus, Parenteral formulation.
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de Costa, Samodh; Roser, Bruce; Sen, Shevanti, Pharmaceutical device for the administration of substances to patients.
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Weers, Jeffry G.; Tarara, Thomas E.; Dellamary, Luis A.; Riess, Jean G.; Schutt, Ernest G., Phospholipid-based powders for drug delivery.
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Weers, Jeffry G; Tarara, Thomas E; Dellamary, Luis A; Riess, Jean G; Schutt, Ernest G, Phospholipid-based powders for drug delivery.
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Bartetzko, Norbert, Printable hydrogel for biosensors.
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Bartetzko, Norbert; Specht, Bernfrield; Kunz, Michael, Printable hydrogels for biosensors.
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Patton,John S., Pulmonary delivery of active fragments of parathyroid hormone.
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Tarara, Thomas E.; Weers, Jeffry G.; Venthoye, Geraldine, Pulmonary delivery of aminoglycoside.
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Tarara, Thomas E; Weers, Jeffry G; Venthoye, Maria Geraldine, Pulmonary delivery of aminoglycoside.
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Tarara, Thomas E.; Weers, Jeffrey G.; Kabalnov, Alexey; Schutt, Ernest G.; Dellamary, Luis A., Pulmonary delivery particles comprising an active agent.
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Weers, Jeffry G.; Schutt, Ernest G.; Dellamary, Luis A.; Tarara, Thomas E.; Kabalnov, Alexey, Respiratory dispersion for metered dose inhalers comprising perforated microstructures.
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Freeman, Dominique M., Sampling module device and method.
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Freeman, Dominique M.; Boecker, Dirk; Alden, Don; Hartmann, Hans-Joachim; Weber, Lutz, Sampling module device and method.
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Freeman,Dominique M.; Boecker,Dirk; Alden,Don; Hartmann,Han Joachim; Weber,Lutz, Sampling module device and method.
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Alden,Don; Freeman,Dominique M., Self optimizing lancing device with adaptation means to temporal variations in cutaneous properties.
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Freeman, Dominique; Alden, Don, Self optimizing lancing device with adaptation means to temporal variations in cutaneous properties.
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DiPerna, Paul M., Slideable flow metering devices and related methods.
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Roser, Bruce J.; Kampinga, Jaap; Colaco, Camilo; Blair, Julian, Solid dose delivery vehicle and methods of making same.
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Roser, Bruce J.; Kampinga, Jaap; Colaco, Camilo; Blair, Julian, Solid dose delivery vehicle and methods of making same.
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Roser, Bruce J.; Kampinga, Jaap; Colaco, Camilo; Blair, Julian, Solid dose delivery vehicle and methods of making same.
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Brown, David, Solute concentration measurement device and related methods.
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Weers, Jeffry G.; Schutt, Ernest G.; Dellamary, Luis; Tarara, Thomas E.; Kabalnov, Alexey, Stabilized preparations for use in metered dose inhalers.
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Harel, Moti; Tang, Qiong; Rice, Trisha; Jennings, Kimberly; Carpenter, Brian; Drewes, Roger; Raditsis, Elizabeth; Scarbrough, January, Stabilizing composition for biological materials.
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Harel, Moti; Tang, Qiong; Rice, Trisha; Jennings, Kimberly; Carpenter, Brian; Drewes, Roger; Raditsis, Elizabeth; Scarbrough, January, Stabilizing composition for biological materials.
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Dellamary, Luis A.; Reiss, Jean; Schutt, Ernest G.; Weers, Jeffry G.; Tarara, Thomas E., Stable metal ion-lipid powdered pharmaceutical compositions for drug delivery.
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Dellamary, Luis A.; Riess, Jean; Schutt, Ernest G.; Weers, Jeffry G.; Tarara, Thomas E., Stable metal ion-lipid powdered pharmaceutical compositions for drug delivery and methods of use.
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Dellamary, Luis A; Riess, Jean; Schutt, Ernest G; Weers, Jeffry G; Tarara, Thomas E, Stable metal ion-lipid powdered pharmaceutical compositions for drug delivery and methods of use.
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Rosinko, Michael J.; Kruse, Geoffrey A.; Harris, Paul, System and method for detecting occlusions in an infusion pump.
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Metzmaker, Thomas; Saint, Sean; Michaud, Michael; Rosinko, Michael J.; Swanson, Vance, Systems including vial adapter for fluid transfer.
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Greenstein,Michael; Stawitcke,Frederick; Drbal,Vladimir; Mauze,Ganapati R.; Pittaro,Rick; Pering,Richard; Verdonk,Ed; Alden,Don; Ingle,Frank; Drese,Klaus Stefan; Hartmann,Hans Joachim; Soerensen,Olaf, Thermal regulation of fluidic samples within a diagnostic cartridge.
상세보기
Deshmukh, Ajay; Freeman, Dominique; Boecker, Dirk; Alden, Don, Tissue penetration device.
상세보기
Freeman, Dominique M.; Alden, Don, Tissue penetration device.
상세보기
Freeman, Dominique M.; Alden, Don, Tissue penetration device.
상세보기
Freeman, Dominique M.; Alden, Don, Tissue penetration device.
상세보기
Freeman, Dominique M.; Alden, Don, Tissue penetration device.
상세보기
Freeman, Dominique M.; Shoup, Thomas; Perry, Jeffrey; Castle, Mark; Kugizaki, Rodney; Englert, Robert; Alden, Don, Tissue penetration device.
상세보기
Freeman, Dominique; Alden, Don, Tissue penetration device.
상세보기
Freeman, Dominique; Alden, Don, Tissue penetration device.
상세보기
Freeman, Dominique; Alden, Don, Tissue penetration device.
상세보기
Freeman, Dominique; Boecher, Dirk; Alden, Don; Briggs, Barry Dean; Leonard, Jon Hewitt; Freeman, Ray; Gogue, George, Tissue penetration device.
상세보기
Freeman, Dominique; Boecker, Dirk; Alden, Don; Briggs, Barry Dean; Leonard, Jon Hewitt; Freeman, Ray; Gogue, George, Tissue penetration device.
상세보기
Freeman, Dominique; Boecker, Dirk; Alden, Don; Briggs, Barry Dean; Leonard, Jon Hewitt; Freeman, Ray; Gogue, George, Tissue penetration device.
상세보기
Freeman, Dominique; Boecker, Dirk; Alden, Don; Briggs, Barry Dean; Leonard, Jon Hewitt; Freeman, Ray; Gogue, George, Tissue penetration device.
상세보기
Freeman, Dominique; Boecker, Dirk; Alden, Don; Briggs, Barry Dean; Leonard, Jon Hewitt; Freeman, Ray; Gogue, George, Tissue penetration device.
상세보기
Freeman, Dominique; Boecker, Dirk; Alden, Don; Briggs, Barry Dean; Leonard, Jon Hewitt; Freeman, Ray; Gogue, George, Tissue penetration device.
상세보기
Freeman, Dominique; Boecker, Dirk; Alden, Don; Briggs, Barry Dean; Leonard, Jon Hewitt; Freeman, Ray; Gogue, George, Tissue penetration device.
상세보기
Freeman, Dominique; Boecker, Dirk; Alden, Don; Briggs, Barry Dean; Leonard, Jon Hewitt; Freeman, Ray; Gogue, George, Tissue penetration device.
상세보기
Freeman, Dominique; Boecker, Dirk; Alden, Don; Briggs, Barry Dean; Leonard, Jon Hewitt; Freeman, Ray; Gogue, George, Tissue penetration device.
상세보기
Freeman, Dominique; Boecker, Dirk; Alden, Don; Briggs, Barry Dean; Leonard, Jon Hewitt; Freeman, Ray; Gogue, George, Tissue penetration device.
상세보기
Freeman, Dominique; Boecker, Dirk; Alden, Don; Briggs, Barry Dean; Leonard, Jon Hewitt; Freeman, Ray; Gogue, George, Tissue penetration device.
상세보기
Freeman, Dominique; Briggs, Barry Dean; Alden, Don, Tissue penetration device.
상세보기
Freeman,Dominique M.; Boecker,Dirk; Alden,Don; Briggs,Barry Dean; Leonard,Jon Hewitt; Freeman,Ray; Gogue,George, Tissue penetration device.
상세보기
DiPerna, Paul M., Two chamber pumps and related methods.
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IPC	Description
A	생활필수품
A62	인명구조; 소방(사다리 E06C)
A62B	인명구조용의 기구, 장치 또는 방법(특히 의료용에 사용되는 밸브 A61M 39/00; 특히 물에서 쓰이는 인명구조 장치 또는 방법 B63C 9/00; 잠수장비 B63C 11/00; 특히 항공기에 쓰는 것, 예. 낙하산, 투출좌석 B64D; 특히 광산에서 쓰이는 구조장치 E21F 11/00)
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Solid dose delivery vehicle and methods of making same 원문보기