[특허]Suppression of vascular disorders by mucosal administration of heat shock protein peptides

Suppression of vascular disorders by mucosal administration of heat shock protein peptides 원문보기

IPC분류정보
국가/구분	United States(US) Patent 등록
국제특허분류(IPC7판)	A61K-038/00 C07K-014/00
출원번호	US-0809745 (2001-03-15)
발명자 / 주소	Weiner, Howard L. Maron, Ruth Libby, Peter
출원인 / 주소	The Brigham & Women's Hospital, Inc.
대리인 / 주소	Wolf, Greenfield & Sacks, P.C.
인용정보	피인용 횟수 : 0 인용 특허 : 37

초록 ▼

Disclosed herein are methods for treating vascular disorders in mammals. The methods involve administering one or more agents selected from the group consisting of a heat shock protein (HSP), a therapeutically effective fragment and a therapeutically effective analog of a heat shock protein in a form suitable for mucosal administration. In some embodiments the heat shock protein of the method is mycobacterial HSP65. In some embodiments the heat shock protein is human HSP60. In some embodiments the heat shock protein is chlamydial HSP60. The method is of particular value in the treatment of atherosclerosis. Also disclosed are compositions useful for treating vascular disorders in mammals. The compositions include one or more agents selected from the group consisting of heat shock protein, therapeutically effective fragments and therapeutically effective analogs of said heat shock protein in aerosol or oral form. In some embodiments the heat shock protein of the composition is mycobacterial HSP65. In some embodiments the heat shock protein of the method is human HSP60. In some embodiments the heat shock protein is chlamydial HSP60. The composition is of particular value in the treatment of atherosclerosis.

대표청구항 ▼

1. A method for treating a vascular disorder in a mammal, which comprises administering to a mucosal surface of said mammal an effective amount of a composition comprising at least one agent selected from the group consisting of an isolated HSP60 heat shock protein, an isolated HSP65 heat shock protein, a therapeutically effective fragment of an isolated HSP60 heat shock protein, and a therapeutically effective fragment of an isolated HSP65 heat shock protein, to treat the vascular disorder. 2. The method of claim 1 wherein said mucosal surface comprises nasal epithelium. 3. The method of claim 1 wherein said mucosal surface comprises oral mucosa. 4. The method of claim 1 wherein said mucosal surface comprises a luminal surface of a gastrointestinal organ selected from the group consisting of: stomach, small intestine, large intestine, and rectum. 5. The method of claim 1 wherein said vascular disorder comprises a cell-mediated immune response. 6. The method of claim 1 wherein said vascular disorder comprises an antibody-mediated immune response. 7. The method of claim 1 wherein said vascular disorder is atherosclerosis. 8. The method of claim 1 wherein said agent is HSP65. 9. The method of claim 1 wherein said agent is human HSP60. 10. The method of claim 1 wherein said agent is chlamydial HSP60. 11. A method for treating a vascular disorder in a mammal, which comprises administering to said mammal by inhalation an effective amount of a composition comprising at least one agent selected from the group consisting of an isolated HSP60 heat shock protein, an isolated HSP65 heat shock protein, a therapeutically effective fragment of an isolated HSP60 heat shock protein, and a therapeutically effective fragment of an isolated HSP65 heat shock protein, to treat the vascular disorder. 12. A method for suppressing a vascular disorder in a mammal, which comprises administering to said mammal via the pulmonary tract an effective amount of at least one agent selected from the group consisting of an isolated HSP60 heat shock protein, an isolated HSP65 heat shock protein, a therapeutically effective fragment of an isolated HSP60 heat shock protein, and a therapeutically effective fragment of an isolated HSP65 heat shock protein, to treat the vascular disorder. 13. A method for treating a vascular disorder in a mammal, which comprises orally or enterally administering to said mammal an effective amount of a composition comprising at least one agent selected from the group consisting of an isolated HSP60 heat shock protein, an isolated HSP65 heat shock protein, a therapeutically effective fragment of an isolated HSP60 heat shock protein, and a therapeutically effective fragment of an isolated HSP65 heat shock protein, to treat the vascular disorder.

이 특허에 인용된 특허 (37)

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Lee Eun Soo (Redwood City CA) Theeuwes Felix (Los Altos CA) Wong Patrick S. L. (Palo Alto CA) Yum Su Il (Los Altos CA) Gale Robert M. (Los Altos CA) Zaffaroni Alejandro (Atherton CA), Delayed onset transdermal delivery device.
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Lee Eun Soo (Redwood City CA) Theeuwes Felix (Los Altos Hills CA) Wong S. L. Patrick (Hayward CA) Yum Su Il (Los Altos CA) Zaffaroni Alejandro (Atherton CA), Delayed onset transdermal delivery device.
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Cohen Irun R. (Rehovot ILX) Elias Dana (Rehovot ILX) Markovits Doron (Rehovot ILX), Diagnosis and treatment of insulin dependent diabetes mellitus.
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Porter Stuart C. (Hatfield PA) Woznicki Edward J. (Douglassville PA) Grillo Susan M. (North Wales PA) D\Andrea Louis F. (King of Prussia PA), Enteric film-coating compositions.
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Porter, Stuart C.; Woznicki, Edward J.; Grillo, Susan M.; D'Andrea, Louis F., Enteric film-coating compositions.
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Srivastava Pramod K. ; Chandawarkar Rajiv Y., Method and compositions for the treatment of autoimmune disease using heat shock proteins.
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Nagai Tsuneji (Chofu JPX) Machida Yoshiharu (Kawasaki JPX) Suzuki Yoshiki (Hino JPX) Ikura Hiroshi (Hino JPX), Method and preparation for administration to the mucosa of the oral or nasal cavity.
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Engstrom Sven (Lund SEX) Lindman Bjorn (Lund SEX) Larsson Kare (Bjarred SEX), Method of preparing controlled-release preparations for biologically active materials and resulting compositions.
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Cohen Irun R.,ILX ; Birk Ohad, Method of reducing the severity of host vs graft reaction by down-regulating hsp60 autoimmunity.
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Hafler David Allen ; Nussenblatt Robert B. ; Palestine Alan G. ; Weiner Howard L., Method of treating or preventing autoimmune uveoretinitis in mammals.
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Hafler David Allen (W. Newton MA) Weiner Howard L. (Brookline MA), Prevention of autoimmune diseases by aerosol administration of autoantigens.
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Suppression of vascular disorders by mucosal administration of heat shock protein peptides 원문보기

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